MRGX1_RAT
ID MRGX1_RAT Reviewed; 323 AA.
AC Q8R4G1; Q7TN42;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 3.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Mas-related G-protein coupled receptor member X1;
DE AltName: Full=Sensory neuron-specific G-protein coupled receptor 1;
GN Name=Mrgprx1; Synonyms=Mrgc, Mrgprc, Mrgprc11, Snsr, Snsr1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley;
RX PubMed=11850634; DOI=10.1038/nn815;
RA Lembo P.M.C., Grazzini E., Groblewski T., O'Donnell D., Roy M.-O.,
RA Zhang J., Hoffert C., Cao J., Schmidt R., Pelletier M., Labarre M.,
RA Gosselin M., Fortin Y., Banville D., Shen S., Stroem P., Payza K., Dray A.,
RA Walker P., Ahmad S.;
RT "Proenkephalin A gene products activate a new family of sensory neuron-
RT specific GPCRs.";
RL Nat. Neurosci. 5:201-209(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley;
RX PubMed=12909716; DOI=10.1073/pnas.1732949100;
RA Zylka M.J., Dong X., Southwell A.L., Anderson D.J.;
RT "Atypical expansion in mice of the sensory neuron-specific Mrg G protein-
RT coupled receptor family.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003).
CC -!- FUNCTION: Orphan receptor activated by neuropeptides terminating in
CC Arg-Phe or Arg-Phe-amide. Mediates its action by association with G
CC proteins that activate a phosphatidylinositol-calcium second messenger
CC system. Its effect is mediated by G(q) and G(11) proteins. May regulate
CC the function of nociceptive neurons by modulation of pain perception
CC (By similarity). {ECO:0000250|UniProtKB:Q96LB2}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Uniquely localized in a subset of small dorsal root
CC and trigeminal sensory neurons. Associated preferentially with IB4
CC class of small-diameter somatosensory afferents (also known as
CC nociceptors). {ECO:0000269|PubMed:11850634,
CC ECO:0000269|PubMed:12909716}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL86877.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF474986; AAL86877.2; ALT_INIT; Genomic_DNA.
DR EMBL; AF518245; AAQ08317.1; -; Genomic_DNA.
DR RefSeq; NP_001002286.1; NM_001002286.1.
DR RefSeq; NP_750845.2; NM_172158.2.
DR RefSeq; XP_017444332.1; XM_017588843.1.
DR AlphaFoldDB; Q8R4G1; -.
DR SMR; Q8R4G1; -.
DR STRING; 10116.ENSRNOP00000019061; -.
DR BindingDB; Q8R4G1; -.
DR ChEMBL; CHEMBL3341575; -.
DR GlyGen; Q8R4G1; 1 site.
DR PaxDb; Q8R4G1; -.
DR GeneID; 282547; -.
DR GeneID; 404646; -.
DR KEGG; rno:282547; -.
DR UCSC; RGD:632284; rat.
DR CTD; 259249; -.
DR CTD; 404646; -.
DR RGD; 632284; Mrgprx1.
DR eggNOG; ENOG502RTWA; Eukaryota.
DR InParanoid; Q8R4G1; -.
DR OrthoDB; 1123658at2759; -.
DR PhylomeDB; Q8R4G1; -.
DR TreeFam; TF336336; -.
DR PRO; PR:Q8R4G1; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007635; P:chemosensory behavior; ISO:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISO:RGD.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR InterPro; IPR027338; MRGPCRX1/MRGPCRX2.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR PANTHER; PTHR11334:SF27; PTHR11334:SF27; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR02108; MRGPCRFAMILY.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..323
FT /note="Mas-related G-protein coupled receptor member X1"
FT /id="PRO_0000070109"
FT TOPO_DOM 1..30
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..59
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..180
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 202..226
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 248..258
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 280..323
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 16
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 105..107
FT /note="AAI -> VAF (in Ref. 2; AAQ08317)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 323 AA; 37074 MW; 40DE6E2C6420EE4B CRC64;
MDPTISSLST ESTTLNKTGH PSCRPILTLS FLVPIITLLG LAGNTIVLWL LGFRMRRKAI
SVYVLNLSLA DSFFLCCHFI DSLMRIMNFY GIYAHKLSKE ILGNAAIIPY ISGLSILSAI
STERCLSVLW PIWYHCHRPR NMSAIICVLI WVLSFLMGIL DWFFSGFLGE THHHLWKNVD
FIVTAFLIFL FMLLFGSSLA LLVRILCGSR RKPLSRLYVT ISLTVMVYLI CGLPLGLYLF
LLYWFGIHLH YPFCHIYQVT VLLSCVNSSA NPIIYFLVGS FRHRKKHRSL KMVLKRALEE
TPEEDEYTDS HVQKPTEISE RRC
