ID   MRGX2_GORGO             Reviewed;         329 AA.
AC   Q4QXU0;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Mas-related G-protein coupled receptor member X2;
GN   Name=MRGPRX2; Synonyms=MRGX2;
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15862286; DOI=10.1016/j.gene.2005.03.001;
RA   Yang S., Liu Y., Lin A.A., Cavalli-Sforza L.L., Zhao Z., Su B.;
RT   "Adaptive evolution of MRGX2, a human sensory neuron specific gene involved
RT   in nociception.";
RL   Gene 352:30-35(2005).
CC   -!- FUNCTION: Mast cell-specific receptor for basic secretagogues, i.e.
CC       cationic amphiphilic drugs, as well as endo- or exogenous peptides,
CC       consisting of a basic head group and a hydrophobic core. Recognizes and
CC       binds small molecules containing a cyclized tetrahydroisoquinoline
CC       (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs),
CC       including tubocurarine and atracurium. In response to these compounds,
CC       mediates pseudo-allergic reactions characterized by histamine release,
CC       inflammation and airway contraction. {ECO:0000250|UniProtKB:Q3KNA1}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AY651167; AAW70080.1; -; Genomic_DNA.
DR   EMBL; AY651168; AAW70081.1; -; Genomic_DNA.
DR   RefSeq; XP_004050859.2; XM_004050811.2.
DR   RefSeq; XP_018891557.1; XM_019036012.1.
DR   AlphaFoldDB; Q4QXU0; -.
DR   SMR; Q4QXU0; -.
DR   Ensembl; ENSGGOT00000015883; ENSGGOP00000035489; ENSGGOG00000015832.
DR   GeneID; 101146219; -.
DR   KEGG; ggo:101146219; -.
DR   GeneTree; ENSGT01030000234639; -.
DR   InParanoid; Q4QXU0; -.
DR   OrthoDB; 1123658at2759; -.
DR   Proteomes; UP000001519; Chromosome 11.
DR   Bgee; ENSGGOG00000015832; Expressed in testis.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; ISS:UniProtKB.
DR   GO; GO:1990595; F:mast cell secretagogue receptor activity; ISS:UniProtKB.
DR   GO; GO:0042923; F:neuropeptide binding; IEA:Ensembl.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0045576; P:mast cell activation; ISS:UniProtKB.
DR   GO; GO:0043303; P:mast cell degranulation; ISS:UniProtKB.
DR   GO; GO:0032467; P:positive regulation of cytokinesis; IEA:Ensembl.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR026234; MRGPCRFAMILY.
DR   PANTHER; PTHR11334; PTHR11334; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR02108; MRGPCRFAMILY.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..329
FT                   /note="Mas-related G-protein coupled receptor member X2"
FT                   /id="PRO_0000069774"
FT   TOPO_DOM        1..33
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        55..63
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        85..96
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        118..144
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        166..183
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        205..227
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        249..263
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..284
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        285..329
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   329 AA;  36936 MW;  AD91A22F6D360156 CRC64;
     MDPTTPAWRT ESTTMNGNDQ ALPLLCGKEI LISVFLILFI ALVGLVGNGF VLWLLGFRMR
     RNAFSVYVLS LAGADFLFLC FQIINCLVYL SNFFCSSSIN FPSFFTTVMT CAYLAGLSML
     STISTERCLS VLWPIWYRCR RPRHLSAVAC VLLWALSLLL SILEGKFCGL FGDGDSGWCQ
     TFDLITAAWL IFLFMVLCGS SLALLVRILC GSRGLPLTRL YLTILLTVLV FLLCGLPFGI
     QWFLILWIWK NSDVLFCHIH PVSVVLSSLN SSANPIIYFF VGSFRKQWQL QQPILKLALQ
     RALQDIAEVD HSEGCFRQGT PEMSRSSLV