ID   MRGX2_MACMU             Reviewed;         329 AA.
AC   Q4QXU5;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Mas-related G-protein coupled receptor member X2;
GN   Name=MRGPRX2; Synonyms=MRGX2;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15862286; DOI=10.1016/j.gene.2005.03.001;
RA   Yang S., Liu Y., Lin A.A., Cavalli-Sforza L.L., Zhao Z., Su B.;
RT   "Adaptive evolution of MRGX2, a human sensory neuron specific gene involved
RT   in nociception.";
RL   Gene 352:30-35(2005).
CC   -!- FUNCTION: Mast cell-specific receptor for basic secretagogues, i.e.
CC       cationic amphiphilic drugs, as well as endo- or exogenous peptides,
CC       consisting of a basic head group and a hydrophobic core. Recognizes and
CC       binds small molecules containing a cyclized tetrahydroisoquinoline
CC       (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs),
CC       including tubocurarine and atracurium. In response to these compounds,
CC       mediates pseudo-allergic reactions characterized by histamine release,
CC       inflammation and airway contraction. {ECO:0000250|UniProtKB:Q3KNA1}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AY651163; AAW70076.1; -; Genomic_DNA.
DR   RefSeq; NP_001035512.1; NM_001040422.1.
DR   AlphaFoldDB; Q4QXU5; -.
DR   SMR; Q4QXU5; -.
DR   STRING; 9544.ENSMMUP00000021221; -.
DR   ChEMBL; CHEMBL3831324; -.
DR   GeneID; 692078; -.
DR   KEGG; mcc:692078; -.
DR   CTD; 117194; -.
DR   eggNOG; ENOG502RTWA; Eukaryota.
DR   InParanoid; Q4QXU5; -.
DR   OrthoDB; 1123658at2759; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; ISS:UniProtKB.
DR   GO; GO:1990595; F:mast cell secretagogue receptor activity; ISS:UniProtKB.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0045576; P:mast cell activation; ISS:UniProtKB.
DR   GO; GO:0043303; P:mast cell degranulation; ISS:UniProtKB.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR026234; MRGPCRFAMILY.
DR   PANTHER; PTHR11334; PTHR11334; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR02108; MRGPCRFAMILY.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..329
FT                   /note="Mas-related G-protein coupled receptor member X2"
FT                   /id="PRO_0000069777"
FT   TOPO_DOM        1..33
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        55..63
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        85..96
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..116
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        117..143
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        165..183
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        205..227
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        249..263
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..284
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        285..329
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   329 AA;  37041 MW;  02AB400A7BC7EB99 CRC64;
     MDPTTPAWGT ESTTMNGNDQ ALPLLCGKET MISVFLILFI ALVGLVGNAF VLWLLGFRMR
     RNAFSVYVLS LAGADFLFLC FQMTSCLAYL INFFGSISIN IPSFFTVMTC AYLAGLSMLS
     AISTERCLSV LWPIWYRCRR PRHLSAVMCV LLWALSLLLS ILEGKFCGFL FSDDDPGWCQ
     TFDFITAAWL MFLFVVLCGS SLALLVRILC GSRSLPLTRL YLTILLTVLI FLLCGLPFGI
     QWFLILWIWK NSVVLFCHIH PISVVLSSFN SSANPIIYFF VGSFRKQWRL RQPILKLALQ
     RALQDTAEVD HSEGCFSQGT LEMSRSSLV