ID   MRGX2_PONPY             Reviewed;         330 AA.
AC   Q4QXU3;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Mas-related G-protein coupled receptor member X2;
GN   Name=MRGPRX2; Synonyms=MRGX2;
OS   Pongo pygmaeus (Bornean orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15862286; DOI=10.1016/j.gene.2005.03.001;
RA   Yang S., Liu Y., Lin A.A., Cavalli-Sforza L.L., Zhao Z., Su B.;
RT   "Adaptive evolution of MRGX2, a human sensory neuron specific gene involved
RT   in nociception.";
RL   Gene 352:30-35(2005).
CC   -!- FUNCTION: Mast cell-specific receptor for basic secretagogues, i.e.
CC       cationic amphiphilic drugs, as well as endo- or exogenous peptides,
CC       consisting of a basic head group and a hydrophobic core. Recognizes and
CC       binds small molecules containing a cyclized tetrahydroisoquinoline
CC       (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs),
CC       including tubocurarine and atracurium. In response to these compounds,
CC       mediates pseudo-allergic reactions characterized by histamine release,
CC       inflammation and airway contraction. {ECO:0000250|UniProtKB:Q3KNA1}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AY651165; AAW70078.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q4QXU3; -.
DR   SMR; Q4QXU3; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; ISS:UniProtKB.
DR   GO; GO:1990595; F:mast cell secretagogue receptor activity; ISS:UniProtKB.
DR   GO; GO:0045576; P:mast cell activation; ISS:UniProtKB.
DR   GO; GO:0043303; P:mast cell degranulation; ISS:UniProtKB.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR026234; MRGPCRFAMILY.
DR   InterPro; IPR027338; MRGPCRX1/MRGPCRX2.
DR   PANTHER; PTHR11334; PTHR11334; 1.
DR   PANTHER; PTHR11334:SF22; PTHR11334:SF22; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR02108; MRGPCRFAMILY.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; G-protein coupled receptor; Membrane; Receptor; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..330
FT                   /note="Mas-related G-protein coupled receptor member X2"
FT                   /id="PRO_0000069779"
FT   TOPO_DOM        1..33
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        55..63
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        85..96
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        118..144
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        166..184
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        206..228
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        250..264
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        286..330
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   330 AA;  37126 MW;  ACF3474FBFD8FC19 CRC64;
     MDPTTPAWGN ESTTMNGNDQ ALPLLCGKET LIPVFLILFI ALVGLVGNGF VLWLLGFCMR
     RNAFSVYVLS LAGADFLFLC FQLINCLVYL SNFFCSISID FPSFFTTVMT CAYLAGLSML
     STISTERCLS VLWPIWYRCR RPRHLSAVVC VLLWALSLLL SILEGKFCGF FFSDGDSGWC
     QTFDFITAAW LIFLFMVLCG SSLALLVRIL CGSRGLPLTR LYLTILLTVL VFLLCGLPFG
     IQWFLILWIW ENSDVLFCHI HPVSVVLSSL NSSANPIIYF FVGTFRKQWR LQQPILKLAL
     QRALQDTAEV DHSEGCFRQG TPEMSRSSLV