ID   MRGX3_MACMU             Reviewed;         322 AA.
AC   Q2LL16;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Mas-related G-protein coupled receptor member X3;
GN   Name=MRGPRX3;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Blood;
RX   PubMed=16284629; DOI=10.1038/sj.bjp.0706448;
RA   Burstein E.S., Ott T.R., Feddock M., Ma J.-N., Fuhs S., Wong S.,
RA   Schiffer H.H., Brann M.R., Nash N.R.;
RT   "Characterization of the Mas-related gene family: structural and functional
RT   conservation of human and rhesus MrgX receptors.";
RL   Br. J. Pharmacol. 147:73-82(2006).
CC   -!- FUNCTION: Orphan receptor. Probably involved in the function of
CC       nociceptive neurons. May regulate nociceptor function and/or
CC       development, including the sensation or modulation of pain. Potently
CC       activated by enkephalins (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; DQ090914; AAZ42386.1; -; Genomic_DNA.
DR   RefSeq; NP_001035511.1; NM_001040421.1.
DR   AlphaFoldDB; Q2LL16; -.
DR   SMR; Q2LL16; -.
DR   Ensembl; ENSMMUT00000090085; ENSMMUP00000073112; ENSMMUG00000060779.
DR   GeneID; 692077; -.
DR   KEGG; mcc:692077; -.
DR   CTD; 117195; -.
DR   VEuPathDB; HostDB:ENSMMUG00000060779; -.
DR   GeneTree; ENSGT01030000234639; -.
DR   InParanoid; Q2LL16; -.
DR   OrthoDB; 1123658at2759; -.
DR   Proteomes; UP000006718; Chromosome 14.
DR   Bgee; ENSMMUG00000060779; Expressed in liver and 1 other tissue.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR026234; MRGPCRFAMILY.
DR   PANTHER; PTHR11334; PTHR11334; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR02108; MRGPCRFAMILY.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..322
FT                   /note="Mas-related G-protein coupled receptor member X3"
FT                   /id="PRO_0000252143"
FT   TOPO_DOM        1..31
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        53..60
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        82..96
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        118..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..177
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        199..213
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        235..254
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        276..322
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   322 AA;  36624 MW;  4F78A7FEB9B5C1C0 CRC64;
     MDPTIPALGT SQTPINRREE TPCYKQTLSL TVLTCIISLV GLTGNAVVLW LLGFRMRRNA
     VSTYILNLAA VDFLFLSGHI VRSPLRLISI RHPISKIVNP VMTFPYFIGL SMLSAISTER
     CLSVLWPMWY RCRRPRHLSV VVCVLLWALS LLRSILEWMF CDFLFSGADS VWCETSDFIT
     IAWLIFLCVV LCGSSLVLLV RILCGSRKMP LTRLYVTILL TVLVFLLCGL PFGIQWALFS
     RIHLDWKVLF CHVHLISVFL SSLNSSANPI IYFFVGSFRQ RQNRQNLKLV LQRALQDTPE
     VDEGGGRLPE ETLELSVSRL EQ