ID   MRJP5_APIME             Reviewed;         598 AA.
AC   O97432;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Major royal jelly protein 5;
DE            Short=MRJP-5;
DE   AltName: Full=Bee-milk protein;
DE   Flags: Precursor;
GN   Name=MRJP5;
OS   Apis mellifera (Honeybee).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae;
OC   Apis.
OX   NCBI_TaxID=7460;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Head;
RX   PubMed=10441680; DOI=10.1007/pl00006551;
RA   Albert S., Bhattacharya D., Klaudiny J., Schmitzova J., Simuth J.;
RT   "The family of major royal jelly proteins and its evolution.";
RL   J. Mol. Evol. 49:290-297(1999).
CC   -!- FUNCTION: May play an important role in honeybee nutrition. It is found
CC       in the royal jelly which is the food of the queen honey bee larva. The
CC       royal jelly determines the development of the young larvae and is
CC       responsible for the high reproductive ability of the honeybee queen.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Hypopharyngeal glands of nurse honey bees.
CC   -!- DEVELOPMENTAL STAGE: Produced by the cephalic glandular system of the
CC       nurse honey bee.
CC   -!- SIMILARITY: Belongs to the major royal jelly protein family.
CC       {ECO:0000305}.
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DR   EMBL; AF004842; AAD01205.1; -; mRNA.
DR   RefSeq; NP_001011599.1; NM_001011599.1.
DR   AlphaFoldDB; O97432; -.
DR   SMR; O97432; -.
DR   STRING; 7460.GB55208-PA; -.
DR   PaxDb; O97432; -.
DR   EnsemblMetazoa; NM_001011599; NP_001011599; GeneID_406116.
DR   GeneID; 406116; -.
DR   KEGG; ame:406116; -.
DR   CTD; 406116; -.
DR   eggNOG; ENOG502SCJK; Eukaryota.
DR   InParanoid; O97432; -.
DR   OrthoDB; 940689at2759; -.
DR   PhylomeDB; O97432; -.
DR   Proteomes; UP000005203; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.120.10.30; -; 2.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR017996; Royal_jelly/protein_yellow.
DR   PANTHER; PTHR10009; PTHR10009; 2.
DR   Pfam; PF03022; MRJP; 2.
DR   PRINTS; PR01366; ROYALJELLY.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..598
FT                   /note="Major royal jelly protein 5"
FT                   /id="PRO_0000031047"
FT   CARBOHYD        148
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        164
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        181
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        324
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   598 AA;  70236 MW;  2C603C77E7ACDF63 CRC64;
     MTTWLLLVVC LGIACQGITS VTVRENSPRK LANSMNVIHE WKYLDYDFGS DERRQAAMQS
     GEYDHTKNYP FDVDQWRGMT FVTVPRYKGV PSSLNVISEK IGNGGRLLQP YPDWSWANYK
     DCSGIVSAYK IAIDKFDRLW ILDSGIINNT QPMCSPKLHV FDLNTSHQLK QVVMPHDIAV
     NASTGNGGLV SLVVQAMDPV NTIVYMADDK GDALIVYQNS DESFHRLTSN TFDYDPKYIK
     MMDAGESFTA QDGIFGMALS PMTNNLYYSP LSSRSLYYVN TKPFMKSEYG ANNVQYQGVQ
     DIFNTESIAK IMSKNGVLFF GLMNNSAIGC WNEHQPLQRE NMDMVAQNEE TLQTVVAMKM
     MHLPQSNKMN RMHRMNRVNR VNRMDRMDRI DRMDRMDRMD TMDTMDRIDR MDRMDRIDRI
     DRMHTMDTMD TMDRTDKMSS MDRMDRMDRV DRMDTMDRTD KMSSMDRMDR MDRVDTMDTM
     DTMDRMDRMD RMDRMDRMDR MDTMDRTDKM SRIDRMDKID RMDRMDRTNR MDRMNRMNRQ
     MNEYMMALSM KLQKFINNDY NFNEVNFRIL GANVNDLIMN TRCANSDNQN NNQNKHNN