ID   MRKE_KLEPN              Reviewed;         269 AA.
AC   P21649;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Protein MrkE;
GN   Name=mrkE;
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=IA565;
RX   PubMed=1670938; DOI=10.1128/jb.173.2.916-920.1991;
RA   Allen B.L., Gerlach G.-F., Clegg S.;
RT   "Nucleotide sequence and functions of mrk determinants necessary for
RT   expression of type 3 fimbriae in Klebsiella pneumoniae.";
RL   J. Bacteriol. 173:916-920(1991).
CC   -!- FUNCTION: May be involved in the regulation of fimbrial expression.
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DR   EMBL; M55912; AAA25092.1; -; Genomic_DNA.
DR   PIR; A39142; A39142.
DR   PDB; 2QV0; X-ray; 2.40 A; A/B=52-183.
DR   PDBsum; 2QV0; -.
DR   AlphaFoldDB; P21649; -.
DR   SMR; P21649; -.
DR   EvolutionaryTrace; P21649; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR007492; LytTR_DNA-bd_dom.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50930; HTH_LYTTR; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA-binding; Fimbrium biogenesis; Phosphoprotein;
KW   Transcription; Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..269
FT                   /note="Protein MrkE"
FT                   /id="PRO_0000081140"
FT   DOMAIN          59..173
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          197..269
FT                   /note="HTH LytTR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00112"
FT   MOD_RES         110
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   STRAND          59..63
FT                   /evidence="ECO:0007829|PDB:2QV0"
FT   HELIX           67..80
FT                   /evidence="ECO:0007829|PDB:2QV0"
FT   STRAND          84..90
FT                   /evidence="ECO:0007829|PDB:2QV0"
FT   HELIX           92..101
FT                   /evidence="ECO:0007829|PDB:2QV0"
FT   STRAND          105..109
FT                   /evidence="ECO:0007829|PDB:2QV0"
FT   STRAND          114..116
FT                   /evidence="ECO:0007829|PDB:2QV0"
FT   HELIX           118..125
FT                   /evidence="ECO:0007829|PDB:2QV0"
FT   STRAND          133..139
FT                   /evidence="ECO:0007829|PDB:2QV0"
FT   HELIX           144..149
FT                   /evidence="ECO:0007829|PDB:2QV0"
FT   STRAND          153..159
FT                   /evidence="ECO:0007829|PDB:2QV0"
FT   HELIX           162..178
FT                   /evidence="ECO:0007829|PDB:2QV0"
SQ   SEQUENCE   269 AA;  30290 MW;  416003BC3650E938 CRC64;
     MPGNKIGLLN VHHRVKLLYG EGLHIRNLTP GTEIAFYVPN NSTPQGDGVA VVMSGEKMKV
     IIVEDEFLAQ QELSWLINTH SQMEIVGSFD DGLDVLKFLQ HNKVDAIFLD INIPSLDGVL
     LAQNISQFAH KPFIVFITAW KEHAVEAFEL EAFDYILKPY QESRIINMLQ KLTTAWEQQN
     NAASGLASAA PRENDTINLI KDERIIVTSI HDIYYAEAHE KMTFVYTRRE SFVMPMNITE
     FVPDALNIAA SGQSKFLLTV AQVSIANRF