ID   MRL1_ASHGO              Reviewed;         273 AA.
AC   Q75BD5;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Mannose 6-phosphate receptor-like protein 1;
DE   Flags: Precursor;
GN   Name=MRL1; OrderedLocusNames=ADL369C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Sorting receptor involved in the transport of vacuolar
CC       enzymes from the Golgi complex to the vacuole. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC       Endosome membrane {ECO:0000250}; Single-pass type I membrane protein
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MRL1/IGF2R family. {ECO:0000305}.
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DR   EMBL; AE016817; AAS51551.1; -; Genomic_DNA.
DR   RefSeq; NP_983727.1; NM_209080.1.
DR   AlphaFoldDB; Q75BD5; -.
DR   SMR; Q75BD5; -.
DR   STRING; 33169.AAS51551; -.
DR   EnsemblFungi; AAS51551; AAS51551; AGOS_ADL369C.
DR   GeneID; 4619862; -.
DR   KEGG; ago:AGOS_ADL369C; -.
DR   eggNOG; KOG4504; Eukaryota.
DR   HOGENOM; CLU_053195_0_0_1; -.
DR   InParanoid; Q75BD5; -.
DR   OMA; KKLTMKY; -.
DR   Proteomes; UP000000591; Chromosome IV.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0007034; P:vacuolar transport; IBA:GO_Central.
DR   Gene3D; 2.70.130.10; -; 1.
DR   InterPro; IPR009011; Man6P_isomerase_rcpt-bd_dom_sf.
DR   InterPro; IPR044865; MRH_dom.
DR   SUPFAM; SSF50911; SSF50911; 1.
DR   PROSITE; PS51914; MRH; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Endosome; Glycoprotein; Golgi apparatus; Membrane;
KW   Protein transport; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix; Transport.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..273
FT                   /note="Mannose 6-phosphate receptor-like protein 1"
FT                   /id="PRO_0000042714"
FT   TOPO_DOM        25..176
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        195..273
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          30..168
FT                   /note="MRH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01262"
FT   CARBOHYD        36
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        51
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        69
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        153
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        32..75
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01262"
FT   DISULFID        120..154
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01262"
FT   DISULFID        135..166
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01262"
SQ   SEQUENCE   273 AA;  29567 MW;  931ECDBD26122ED4 CRC64;
     MPTQLQRPLA RLLALALLVL LARAAEDEPP FCAVRNRSTG SYIDLSPLAS NVSGTPPNWL
     VRGWQYGANF TLGVCTSPLG DGPAAYYSDT GRRVSIGRVA TTPRYTGKKL TLTYEGGDLC
     PNRVDRKSSL LYFVCDRDIH TIAQVSLLGV LHNCSYLFEV RSVHACAAAR AAGDRSVLGI
     FAAILLVFAA VELARRCCAA PLRRRFRPDF PADRPRWAPA PTGWAARTRA FFARAAEPRQ
     AIKLASSPPG HPASDMEAQN TLLDSLDVRS SGA