MRNIP_DANRE
ID MRNIP_DANRE Reviewed; 395 AA.
AC Q32PP1;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=MRN complex-interacting protein {ECO:0000250|UniProtKB:Q6NTE8};
DE AltName: Full=MRN-interacting protein {ECO:0000250|UniProtKB:Q6NTE8};
GN Name=mrnip {ECO:0000250|UniProtKB:Q6NTE8}; ORFNames=zgc:123335;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in the cellular response to DNA damage and the
CC maintenance of genome stability through its association with the MRN
CC damage-sensing complex. Promotes chromatin loading and activity of the
CC MRN complex to facilitate subsequent ATM-mediated DNA damage response
CC signaling and DNA repair. {ECO:0000250|UniProtKB:Q6NTE8}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6NTE8}. Nucleus,
CC nucleoplasm {ECO:0000250|UniProtKB:Q6NTE8}.
CC -!- SIMILARITY: Belongs to the MRNIP family. {ECO:0000305}.
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DR EMBL; BC108042; AAI08043.1; -; mRNA.
DR RefSeq; NP_001032483.1; NM_001037406.1.
DR AlphaFoldDB; Q32PP1; -.
DR STRING; 7955.ENSDARP00000101365; -.
DR PRIDE; Q32PP1; -.
DR ZFIN; ZDB-GENE-051113-228; mrnip.
DR eggNOG; ENOG502S8YD; Eukaryota.
DR InParanoid; Q32PP1; -.
DR PRO; PR:Q32PP1; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; ISS:UniProtKB.
DR GO; GO:1905168; P:positive regulation of double-strand break repair via homologous recombination; ISS:UniProtKB.
DR GO; GO:0045860; P:positive regulation of protein kinase activity; ISS:UniProtKB.
DR GO; GO:0071168; P:protein localization to chromatin; ISS:UniProtKB.
DR GO; GO:2001032; P:regulation of double-strand break repair via nonhomologous end joining; ISS:UniProtKB.
DR GO; GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
DR InterPro; IPR032739; MRNIP.
DR PANTHER; PTHR15863; PTHR15863; 1.
DR Pfam; PF15749; MRNIP; 1.
PE 2: Evidence at transcript level;
KW DNA damage; DNA repair; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..395
FT /note="MRN complex-interacting protein"
FT /id="PRO_0000326121"
FT REGION 90..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 142..145
FT /note="Nuclear localization signal (NLS)"
FT /evidence="ECO:0000250|UniProtKB:Q6NTE8"
FT COMPBIAS 180..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 395 AA; 44921 MW; 38D195CB67DFE613 CRC64;
MVQEFNVLRC FSCQTFQVQQ VKKAKKWTCK VCGEKQSLIK EFGRGAAADC RRHVQKLNAL
RGEQHQLNTQ QLLAQGDEEN ENEDVYEVLD PKSEQEEAHV SRWSKYTDQT TEGPNEEKDD
EDEDENVYTE RPQFRIQGTR KRKKMSSLEP FGGNCDNYEE SRAGYSQFRK QAYLPLQLEK
RSSSSWNKGS VSKYSNCQRP DDVVPSARTK LPSSRQTVGH YPTACSSSTN TMENSIGNKQ
QIKSSYRPPT ADVNKHLPIQ SESPSVSSHQ KFGESTIENK DSKWNKFLTI VPTQDKEEYY
YESQNGKKTL IPYFTKADTV VDFEERRCPA DEKDSGILNR QKVVGGNASC PTTRLPTKSV
GFENAVCKPV LVKAPYSSLS LNPLFCTDED FDDTS