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MRNIP_DANRE
ID   MRNIP_DANRE             Reviewed;         395 AA.
AC   Q32PP1;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=MRN complex-interacting protein {ECO:0000250|UniProtKB:Q6NTE8};
DE   AltName: Full=MRN-interacting protein {ECO:0000250|UniProtKB:Q6NTE8};
GN   Name=mrnip {ECO:0000250|UniProtKB:Q6NTE8}; ORFNames=zgc:123335;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in the cellular response to DNA damage and the
CC       maintenance of genome stability through its association with the MRN
CC       damage-sensing complex. Promotes chromatin loading and activity of the
CC       MRN complex to facilitate subsequent ATM-mediated DNA damage response
CC       signaling and DNA repair. {ECO:0000250|UniProtKB:Q6NTE8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6NTE8}. Nucleus,
CC       nucleoplasm {ECO:0000250|UniProtKB:Q6NTE8}.
CC   -!- SIMILARITY: Belongs to the MRNIP family. {ECO:0000305}.
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DR   EMBL; BC108042; AAI08043.1; -; mRNA.
DR   RefSeq; NP_001032483.1; NM_001037406.1.
DR   AlphaFoldDB; Q32PP1; -.
DR   STRING; 7955.ENSDARP00000101365; -.
DR   PRIDE; Q32PP1; -.
DR   ZFIN; ZDB-GENE-051113-228; mrnip.
DR   eggNOG; ENOG502S8YD; Eukaryota.
DR   InParanoid; Q32PP1; -.
DR   PRO; PR:Q32PP1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; ISS:UniProtKB.
DR   GO; GO:1905168; P:positive regulation of double-strand break repair via homologous recombination; ISS:UniProtKB.
DR   GO; GO:0045860; P:positive regulation of protein kinase activity; ISS:UniProtKB.
DR   GO; GO:0071168; P:protein localization to chromatin; ISS:UniProtKB.
DR   GO; GO:2001032; P:regulation of double-strand break repair via nonhomologous end joining; ISS:UniProtKB.
DR   GO; GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
DR   InterPro; IPR032739; MRNIP.
DR   PANTHER; PTHR15863; PTHR15863; 1.
DR   Pfam; PF15749; MRNIP; 1.
PE   2: Evidence at transcript level;
KW   DNA damage; DNA repair; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..395
FT                   /note="MRN complex-interacting protein"
FT                   /id="PRO_0000326121"
FT   REGION          90..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          180..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           142..145
FT                   /note="Nuclear localization signal (NLS)"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NTE8"
FT   COMPBIAS        180..199
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        209..248
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        256..273
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   395 AA;  44921 MW;  38D195CB67DFE613 CRC64;
     MVQEFNVLRC FSCQTFQVQQ VKKAKKWTCK VCGEKQSLIK EFGRGAAADC RRHVQKLNAL
     RGEQHQLNTQ QLLAQGDEEN ENEDVYEVLD PKSEQEEAHV SRWSKYTDQT TEGPNEEKDD
     EDEDENVYTE RPQFRIQGTR KRKKMSSLEP FGGNCDNYEE SRAGYSQFRK QAYLPLQLEK
     RSSSSWNKGS VSKYSNCQRP DDVVPSARTK LPSSRQTVGH YPTACSSSTN TMENSIGNKQ
     QIKSSYRPPT ADVNKHLPIQ SESPSVSSHQ KFGESTIENK DSKWNKFLTI VPTQDKEEYY
     YESQNGKKTL IPYFTKADTV VDFEERRCPA DEKDSGILNR QKVVGGNASC PTTRLPTKSV
     GFENAVCKPV LVKAPYSSLS LNPLFCTDED FDDTS
 
 
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