ID   MRNP_PINMA              Reviewed;         262 AA.
AC   P86871;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-FEB-2011, sequence version 1.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Methionine-rich nacre protein {ECO:0000303|PubMed:21590302};
DE            Short=MRNP {ECO:0000303|PubMed:21590302};
DE   AltName: Full=Methionine-rich nacre protein 34 {ECO:0000303|PubMed:21590302};
DE            Short=Pmax-MRNP34 {ECO:0000303|PubMed:21590302};
DE   Flags: Precursor;
OS   Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Pteriomorphia; Pterioida; Pterioidea; Pteriidae; Pinctada.
OX   NCBI_TaxID=104660;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Mantle {ECO:0000269|PubMed:19915030};
RX   PubMed=19915030; DOI=10.1093/molbev/msp278;
RA   Jackson D.J., McDougall C., Woodcroft B., Moase P., Rose R.A., Kube M.,
RA   Reinhardt R., Rokhsar D.S., Montagnani C., Joubert C., Piquemal D.,
RA   Degnan B.M.;
RT   "Parallel evolution of nacre building gene sets in molluscs.";
RL   Mol. Biol. Evol. 27:591-608(2010).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 45-55 AND 111-120, SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RC   TISSUE=Mantle {ECO:0000269|PubMed:21590302}, and
RC   Nacre {ECO:0000269|PubMed:21590302};
RX   PubMed=21590302; DOI=10.1007/s00726-011-0932-0;
RA   Marie B., Joubert C., Belliard C., Tayale A., Zanella-Cleon I., Marin F.,
RA   Gueguen Y., Montagnani C.;
RT   "Characterization of MRNP34, a novel methionine-rich nacre protein from the
RT   pearl oysters.";
RL   Amino Acids 42:2009-2017(2012).
RN   [3]
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Shell;
RX   PubMed=23213212; DOI=10.1073/pnas.1210552109;
RA   Marie B., Joubert C., Tayale A., Zanella-Cleon I., Belliard C.,
RA   Piquemal D., Cochennec-Laureau N., Marin F., Gueguen Y., Montagnani C.;
RT   "Different secretory repertoires control the biomineralization processes of
RT   prism and nacre deposition of the pearl oyster shell.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:20986-20991(2012).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21590302,
CC       ECO:0000269|PubMed:23213212}.
CC   -!- TISSUE SPECIFICITY: Expressed in mantle and, after secretion,
CC       incorporated into acid-insoluble nacre matrix of the shell (at protein
CC       level). Expressed primarily in the mantle with highest level in the
CC       mantle pallium and lower level in the mantle edge.
CC       {ECO:0000269|PubMed:21590302, ECO:0000269|PubMed:23213212}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-4 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; EZ420111; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; P86871; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..262
FT                   /note="Methionine-rich nacre protein"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000404093"
FT   REGION          26..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   262 AA;  28767 MW;  DE4A561565ABCC0F CRC64;
     MSIMRRILCL AVVIFIINDV SSQGLGNNKN WKKNGMSLSS PGNKKPTGNN AVPQKSKMNN
     MNQNSLSQPK RSSPPGNSMY NMANQGPMGM MGGFGMGMNN KQMREFMIAR RTHGVSPFLK
     KKICHMAKVA PPVNGQMPSP PQLYAQGFKI RRIGKWFSQD LDWSEGVAMC HNKEMEHRGC
     EKTPSSKWGR MFPGMGGMGG MGGMGGMMMG NRPMASCDVT KPNSCGNPAL MKCSKYHKDR
     FGMPVCCATS EMTANQLENM GF