ID   MRNP_PINMG              Reviewed;         260 AA.
AC   P86872; E7EAP8;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 2.
DT   03-AUG-2022, entry version 17.
DE   RecName: Full=Methionine-rich nacre protein {ECO:0000250|UniProtKB:P86871};
DE            Short=MRNP {ECO:0000250|UniProtKB:P86871};
DE   AltName: Full=Methionine-rich nacre protein 34 {ECO:0000303|PubMed:21590302};
DE            Short=Pmarg-MRNP34 {ECO:0000303|PubMed:21590302};
DE   Flags: Precursor;
OS   Margaritifera margaritifera (Freshwater pearl mussel).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Pteriomorphia; Pterioida; Pterioidea; Pteriidae; Pinctada.
OX   NCBI_TaxID=102329;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Mantle {ECO:0000269|PubMed:21040589};
RX   PubMed=21040589; DOI=10.1186/1471-2164-11-613;
RA   Joubert C., Piquemal D., Marie B., Manchon L., Pierrat F.,
RA   Zanella-Cleon I., Cochennec-Laureau N., Gueguen Y., Montagnani C.;
RT   "Transcriptome and proteome analysis of Pinctada margaritifera calcifying
RT   mantle and shell: focus on biomineralization.";
RL   BMC Genomics 11:613-613(2010).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 20-68 AND 103-147, SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RC   TISSUE=Mantle {ECO:0000269|PubMed:21590302}, and
RC   Nacre {ECO:0000269|PubMed:21590302};
RX   PubMed=21590302; DOI=10.1007/s00726-011-0932-0;
RA   Marie B., Joubert C., Belliard C., Tayale A., Zanella-Cleon I., Marin F.,
RA   Gueguen Y., Montagnani C.;
RT   "Characterization of MRNP34, a novel methionine-rich nacre protein from the
RT   pearl oysters.";
RL   Amino Acids 42:2009-2017(2012).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21590302}.
CC   -!- TISSUE SPECIFICITY: Expressed in mantle distal zone, mantle margin and
CC       grafted pearl pockets. Not expressed in adductor muscle, gills,
CC       hemocytes or ungrafted pearl pockets. Within the mantle, specifically
CC       expressed in mineralizing outer epithelium cells (at protein level).
CC       After secretion incorporated into acid-insoluble nacre matrix of shell
CC       and pearl (at protein level). Not found in acid-insoluble matrix of
CC       shell prisms (at protein level). {ECO:0000269|PubMed:21590302}.
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DR   EMBL; HQ625028; ADU05417.1; -; mRNA.
DR   AlphaFoldDB; P86872; -.
DR   PRIDE; P86872; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000269|PubMed:21590302"
FT   CHAIN           20..260
FT                   /note="Methionine-rich nacre protein"
FT                   /evidence="ECO:0000269|PubMed:21590302"
FT                   /id="PRO_0000404094"
FT   REGION          23..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   260 AA;  28455 MW;  5998181E0B59B251 CRC64;
     MRRILCLAVV IFIINDVSSQ GLGSNKNWKK SGMSLSSPGN KKPTGNNNAV PQKSKMNNVN
     QNSLSQPKRP SHPGNSMYFM GNQGPMGMMG GFGMGMNNKQ MREFMIAKRT HGVSPFLKKK
     ICHMAKVAPP VNGIMPSPPQ LYAQGFKIRR IGKWFSHDLD WSEGVAMCHN KEMEHRGCEK
     TPSAKWGRMF PGMGGMGGMG GMGGMMMGSR PMASCDVTKP NSCGNPALMK CSKYHKDRFG
     MPVCCATSEM TANQLENMGF