MRO2A_HUMAN
ID MRO2A_HUMAN Reviewed; 1674 AA.
AC A6NES4; F8VUA0;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2015, sequence version 4.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Maestro heat-like repeat-containing protein family member 2A;
DE AltName: Full=HEAT repeat-containing protein 7B1;
GN Name=MROH2A; Synonyms=HEATR7B1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
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DR EMBL; AC005538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC006985; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A6NES4; -.
DR IntAct; A6NES4; 1.
DR STRING; 9606.ENSP00000477597; -.
DR iPTMnet; A6NES4; -.
DR PhosphoSitePlus; A6NES4; -.
DR BioMuta; MROH2A; -.
DR MassIVE; A6NES4; -.
DR PaxDb; A6NES4; -.
DR PeptideAtlas; A6NES4; -.
DR PRIDE; A6NES4; -.
DR ProteomicsDB; 1010; -.
DR ProteomicsDB; 28711; -.
DR Antibodypedia; 63003; 4 antibodies from 4 providers.
DR Ensembl; ENST00000389758.4; ENSP00000374408.3; ENSG00000185038.15.
DR MANE-Select; ENST00000389758.4; ENSP00000374408.3; NM_001394639.1; NP_001381568.1.
DR UCSC; uc061tvx.1; human.
DR GeneCards; MROH2A; -.
DR HGNC; HGNC:27936; MROH2A.
DR HPA; ENSG00000185038; Tissue enhanced (testis, thyroid gland).
DR neXtProt; NX_A6NES4; -.
DR OpenTargets; ENSG00000185038; -.
DR PharmGKB; PA164720351; -.
DR VEuPathDB; HostDB:ENSG00000185038; -.
DR eggNOG; KOG2032; Eukaryota.
DR GeneTree; ENSGT00940000161309; -.
DR HOGENOM; CLU_003168_1_0_1; -.
DR InParanoid; A6NES4; -.
DR TreeFam; TF315201; -.
DR PathwayCommons; A6NES4; -.
DR SignaLink; A6NES4; -.
DR Pharos; A6NES4; Tdark.
DR PRO; PR:A6NES4; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; A6NES4; protein.
DR Bgee; ENSG00000185038; Expressed in right lobe of liver and 59 other tissues.
DR ExpressionAtlas; A6NES4; baseline and differential.
DR Genevisible; A6NES4; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045206; Maestro_heat-like_prot.
DR PANTHER; PTHR23120; PTHR23120; 1.
DR SUPFAM; SSF48371; SSF48371; 2.
PE 4: Predicted;
KW Reference proteome; Repeat.
FT CHAIN 1..1674
FT /note="Maestro heat-like repeat-containing protein family
FT member 2A"
FT /id="PRO_0000348053"
FT REPEAT 73..96
FT /note="HEAT 1"
FT REPEAT 97..133
FT /note="HEAT 2"
FT REPEAT 195..234
FT /note="HEAT 3"
FT REPEAT 254..292
FT /note="HEAT 4"
FT REPEAT 382..419
FT /note="HEAT 5"
FT REPEAT 424..461
FT /note="HEAT 6"
FT REPEAT 573..612
FT /note="HEAT 7"
FT REPEAT 615..641
FT /note="HEAT 8"
FT REPEAT 642..679
FT /note="HEAT 9"
FT REPEAT 739..776
FT /note="HEAT 10"
FT REPEAT 993..1030
FT /note="HEAT 11"
FT REPEAT 1221..1263
FT /note="HEAT 12"
FT REPEAT 1381..1420
FT /note="HEAT 13"
FT REPEAT 1627..1674
FT /note="HEAT 14"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 11
FT /note="A -> D (in dbSNP:rs6431631)"
FT /id="VAR_046073"
FT VARIANT 271
FT /note="Y -> H (in dbSNP:rs1500481)"
FT /id="VAR_046074"
FT VARIANT 329
FT /note="E -> G (in dbSNP:rs2361503)"
FT /id="VAR_046075"
FT VARIANT 489
FT /note="K -> N (in dbSNP:rs11563246)"
FT /id="VAR_046076"
FT VARIANT 978
FT /note="W -> R (in dbSNP:rs726016)"
FT /id="VAR_046077"
FT VARIANT 1041
FT /note="Q -> E (in dbSNP:rs719418)"
FT /id="VAR_046078"
FT VARIANT 1075
FT /note="S -> T (in dbSNP:rs17864722)"
FT /id="VAR_046079"
FT VARIANT 1107
FT /note="F -> S (in dbSNP:rs1500480)"
FT /id="VAR_046080"
FT VARIANT 1141
FT /note="R -> C (in dbSNP:rs28900688)"
FT /id="VAR_046081"
FT VARIANT 1184
FT /note="V -> M (in dbSNP:rs6734083)"
FT /id="VAR_046082"
FT VARIANT 1410
FT /note="A -> T (in dbSNP:rs28900693)"
FT /id="VAR_046085"
FT VARIANT 1454
FT /note="T -> A (in dbSNP:rs28900694)"
FT /id="VAR_046086"
FT VARIANT 1537
FT /note="M -> V (in dbSNP:rs11563074)"
FT /id="VAR_046087"
FT VARIANT 1546
FT /note="F -> L (in dbSNP:rs28900700)"
FT /id="VAR_046088"
FT VARIANT 1562
FT /note="A -> T (in dbSNP:rs879665)"
FT /id="VAR_046089"
FT VARIANT 1569
FT /note="V -> I (in dbSNP:rs879664)"
FT /id="VAR_046090"
FT VARIANT 1643
FT /note="P -> L (in dbSNP:rs2270856)"
FT /id="VAR_046091"
SQ SEQUENCE 1674 AA; 189561 MW; 5A72297556939F44 CRC64;
MTEAITEAAV ASSEEVSEER DDLGPLELHD SGTFQQVVNL LDIIDSESAK TDTTGAGLDM
RKTLASVIIM EKATTEPSVV INTLIRCLQV PEISTQRKVN IYNILQDIIQ QEGELEEQCV
QRLVAIASKE MREIPEMEGY MKAEVASDTL VALSRNHFSL VMYELQHHLK PLNLTDEFVI
ITLAKLANGN VFEFMPYMGI TLATIFTMLR LANEAKIRQA ICSAMETFCE TVQFYLKHLE
ESVYPVMTEE EFALKVFPMY RYFVTVWLRH YNPEVKLGVI KSLKPMLGLL LPNDDLREQV
YDYIPLLLAE YQGSLEVLFV TQVLRQILEL SVTTNTPVPQ MQLHTIFTEL HVQVCNKAPA
QHQYSSQNLM EMVHCFVALA RSYPKELMKF FFSQMETNKE AVRVGTLNLI RAIVSADEPR
MSIRAIYLAI RVVKNTISDT RSKVRMAILH IIGQLALCGY QERIKGWGLK YLSVQLTLST
YKLTNRREKF YQRDLEERMV HKVTMDTVKI ITSSVSGMTT EFWVRLLCYI METDYVEALT
PICISLTNLA EHQLHGQDVD VSVAGKSRQV DLPAPQKLLA RLLVLMSSPY KGEGRGIAML
NLLRTLSQSI APSMADMWEL EIALLVRYLE EHTEFTWDQK AWEDKLIQFL RNSLKKTRGS
SWSLRLSKEL NNQIASFDSP SLEKGFLYRA LGFTLATGLE ASKVEVLLLE LLYKTDYSND
FDSEGVIMCF GLCARGQVKT VLNVLHDFEE RIQESEQSWQ ISAWRKDHPW RRETVKSALM
VMYSCVASYC HPQLLLNLVD SPITAKIIHH YVSSCQDICL KMAFMKSVVQ VTKAINNIKD
LEDFHFAQKT TLTSIIVAVI KAEPTDNLVS PVRALAMEAL SHLSKLKPFY STEENSELMD
ISIHSVISLQ LPGEDNESIK TLYANALSSL EQLMESLLQR QLDPKGLQEM VQLLEKWILS
EKEWEREKAV SLHLYLMWIY VHSTAVCIHL KLGQFGTMVG LIAPCTCDAH QRTRMASMNV
LSSLLDLHAS QTCSLWGPSK QKELEKCKGD LQSTDVEKIF CASSRIAKVV CMEFSCDEVV
SLIQKLCENT GAMNLQHDKA SVTWIAFFLQ MRAKELEDKV AEILSAILVH LPVVDHPEVR
RLLIDGILLL AHHHQETILT SLLRQPLPME SHLAEVWLAV SENVPFARTM LHSLMGRLQS
RLSPRISATS KADIWRLAAV DPLMTLCTIH LLIQKLDEND KLPDFLPDLI YTLLLQLGSS
HRPEAAPPVL KMWKLVHTTP LPEEMNLQRV TIKSMQLLFK RVKSQHLAHT LDEQAVWDLL
QDGGTFLEGV SLLARLCMQH VEGHRQRLAE LVLRGMDSEV LSCRISSTAV CFMSGPVLYQ
EKLLKPAALL LEKGADQEED EALRVLSLRA LGNMALGAPK KVKQYRKVLL EKCLGPLREP
VSNSVTAEGM EALTKILAEL REGDVGSSFD AMSEQCRIFF DNESELLRLK AFILFGKLAR
VVGMSKKHFF KGEVKKAWIP LMLHSQDPCS NAAQACMATM FQCVHFWGWK SLEHPSGPSD
TATDDKMTVF QTTMCSILTR KKPAVLYRFL LETMAYVKNN LSRIRIAACN LAGIIMKQMS
THYLKKLDFP ALRNSLQELQ LDPDPGVRRA ALETLTVLDS CSQHGFLASP QGMS
