ID   MRO2A_MOUSE             Reviewed;        1679 AA.
AC   D3Z750;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 2.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Maestro heat-like repeat-containing protein family member 2A;
DE   AltName: Full=HEAT repeat-containing protein 7B1;
GN   Name=Mroh2a; Synonyms=Heatr7b1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
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DR   EMBL; AC087780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; D3Z750; -.
DR   STRING; 10090.ENSMUSP00000130508; -.
DR   iPTMnet; D3Z750; -.
DR   PhosphoSitePlus; D3Z750; -.
DR   MaxQB; D3Z750; -.
DR   PaxDb; D3Z750; -.
DR   PeptideAtlas; D3Z750; -.
DR   PRIDE; D3Z750; -.
DR   ProteomicsDB; 290059; -.
DR   Antibodypedia; 63003; 4 antibodies from 4 providers.
DR   Ensembl; ENSMUST00000061013; ENSMUSP00000130508; ENSMUSG00000079429.
DR   MGI; MGI:3705228; Mroh2a.
DR   VEuPathDB; HostDB:ENSMUSG00000079429; -.
DR   eggNOG; KOG2032; Eukaryota.
DR   GeneTree; ENSGT00940000161309; -.
DR   InParanoid; D3Z750; -.
DR   PhylomeDB; D3Z750; -.
DR   TreeFam; TF315201; -.
DR   PRO; PR:D3Z750; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; D3Z750; protein.
DR   Bgee; ENSMUSG00000079429; Expressed in spermatocyte and 97 other tissues.
DR   ExpressionAtlas; D3Z750; baseline and differential.
DR   Genevisible; D3Z750; MM.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR045206; Maestro_heat-like_prot.
DR   PANTHER; PTHR23120; PTHR23120; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
PE   1: Evidence at protein level;
KW   Reference proteome; Repeat.
FT   CHAIN           1..1679
FT                   /note="Maestro heat-like repeat-containing protein family
FT                   member 2A"
FT                   /id="PRO_0000395104"
FT   REPEAT          68..91
FT                   /note="HEAT 1"
FT   REPEAT          92..128
FT                   /note="HEAT 2"
FT   REPEAT          190..229
FT                   /note="HEAT 3"
FT   REPEAT          293..313
FT                   /note="HEAT 4"
FT   REPEAT          314..350
FT                   /note="HEAT 5"
FT   REPEAT          380..417
FT                   /note="HEAT 6"
FT   REPEAT          422..459
FT                   /note="HEAT 7"
FT   REPEAT          571..610
FT                   /note="HEAT 8"
FT   REPEAT          614..654
FT                   /note="HEAT 9"
FT   REPEAT          737..774
FT                   /note="HEAT 10"
FT   REPEAT          848..887
FT                   /note="HEAT 11"
FT   REPEAT          991..1028
FT                   /note="HEAT 12"
FT   REPEAT          1219..1261
FT                   /note="HEAT 13"
FT   REPEAT          1387..1425
FT                   /note="HEAT 14"
FT   REPEAT          1632..1669
FT                   /note="HEAT 15"
SQ   SEQUENCE   1679 AA;  190012 MW;  5F104A42F23258BB CRC64;
     MKEATELNED MLEEAEHLAL LEPEDDGTFF QVTNLLNIMD SESAKTDTTG PGLDMRKTLA
     SVIITEKATT DPCVVMNALI RCLQMPEIST QRKMNIYNIM QEIIQQEGEM EEHCIQRLVA
     IASKQMRDIT EAEDFETAEV ASETLVALSR NHFSLVMYEL QHHLKPLNLT DEFVIVTLAK
     LANGNVFEFM PYMGITLATI FTMLRLANEA KMRQVICSAM ETFCETVQFY LRHLEDSLYP
     VMTEDQFAVK LFPMYRYFVT VWLRHQDLEV KLGVIKSLRP MLSLLLPNDD LREQVYDYIP
     LLLAEFQGTG HWPLFPSLLQ VLRQILEASV TTNTPIPPML LHPIFTELHV QVCSKAPAQQ
     QFSSQNLMEI VHCFIALARS YPKELMKFFF SQVEMSKEAV RVGTLALIRA VVSADDPKIN
     IKTIYLAIRV VKNTLSDTRS KVRMAILRII GQLVLSGFQE KIKGWGLKYV SVQLTLSTYK
     LTNRRECFYQ RDLEEKMVHK VTMDTVKIIT SSISGMTNEF WVRLLCYIME TDYTEALTPI
     CISLTNLAEN QIHGKDTEAG IAGKSKHVDL PAPQKLLARL LVLMSSPYKG EGRGIAMLNL
     LRTLSQSIAP SMADMWEQEI PLLVQYLEEH TEFTWNQKTW EDMLIQFLRN SLKKTRGTSW
     SLRLSKELNN QIETFDSPSL EKGFLYRALG FTLGMGLEAD RVEVLLLELL YKTDYSNDFD
     REGVILCFGL CARGQVKTVL NVLQDFEERI QESEQSWQIG AWRKDHPWRR ETVKSALMVM
     YSCVSSYCHP QMLLTHVDSP ITSKIIHHYS SSCQDISLKM AFMKSVVQVT NAIKSIQDPE
     DFQFAHKSAL TGLIVVIIKA EPPDHLVSPV RSMAMDALSQ LSTMKPFYSP EESTELMDIS
     IHTVISLQPP GEDNESVKTL YANTMSSLKQ LMEGLLQRQL DPKGLQDTVH LLEKWILSEK
     EWEREKAMAL HLHLMQIYVQ SIGVCIPLKL GQFGVLVGLI APCTCDAHRR TRLASINVLS
     SLLDLHVSQT CSLWGTSKEQ ELQKCKEDLQ DTDMNKISSA SSRVAKVVCP EFNCDEVVSL
     IQKLCENIGA MDLQHDRAAV TWIGIFLQMR VKELEDKVAE ILGAILVHLP VVDHPEVRRH
     LIEGILLLAH YHQETVLTSL LRQPLPMESH LTEVWLAVAE NVPFARTMLH GLLGRLQSRF
     TAKINATSKA DIWRLAAVDP LMTLCTIQLL MEKMDQDDKF PDLFPDLLYT FLLQLGSSHG
     PEAASPVLKT WRLVHTGPLP QEMTLQRCSR SRITIKSMQL LVKRINREPL EQALEEQSVW
     SLLENGGTFL EGVSLMARLC MQNMENYMQR LAELVLTGMG SEILSCCISS TAICVEFMSD
     PVLHQEKLLR PVVLMLEKGA GQDKDETLQV LSLRALGNMA LGAPRKVKQY RKLLLEKCLG
     SLQGQVSSSA MAEGMEALTK VLAELREGDI GSSFEAISKQ CRAFFDNESE LLRLKAFVLF
     GKLTKVVGIS KKHFFKGEVK RGWVSLLLHC QDPCPSVAQA CVATMFQCVH FWGWKSLESS
     FGHSNDSINE QMTVFQTNMC SVLAQKKPAV LCGFLLETTV FMKNNLSRIR IAACNLAGII
     MKQLSAHYLK KMDLVGLRNS LQDLQLDSDA GVRRAALETL KVLDSCNQHW LLASPRGLP