MROH1_DICDI
ID MROH1_DICDI Reviewed; 1647 AA.
AC Q54F23;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Maestro heat-like repeat-containing protein family member 1;
DE AltName: Full=HEAT repeat-containing protein 7A homolog;
GN Name=mroh1; Synonyms=heatr7a; ORFNames=DDB_G0291161;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
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DR EMBL; AAFI02000175; EAL61864.1; -; Genomic_DNA.
DR RefSeq; XP_635367.1; XM_630275.1.
DR AlphaFoldDB; Q54F23; -.
DR STRING; 44689.DDB0189282; -.
DR PaxDb; Q54F23; -.
DR EnsemblProtists; EAL61864; EAL61864; DDB_G0291161.
DR GeneID; 8628015; -.
DR KEGG; ddi:DDB_G0291161; -.
DR dictyBase; DDB_G0291161; mroh1.
DR eggNOG; KOG2032; Eukaryota.
DR HOGENOM; CLU_003168_0_1_1; -.
DR InParanoid; Q54F23; -.
DR OMA; CENTLYM; -.
DR PhylomeDB; Q54F23; -.
DR PRO; PR:Q54F23; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; IDA:dictyBase.
DR GO; GO:0071203; C:WASH complex; IDA:dictyBase.
DR GO; GO:0006887; P:exocytosis; IMP:dictyBase.
DR Gene3D; 1.25.10.10; -; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045206; Maestro_heat-like_prot.
DR PANTHER; PTHR23120; PTHR23120; 1.
DR SUPFAM; SSF48371; SSF48371; 2.
PE 4: Predicted;
KW Reference proteome; Repeat.
FT CHAIN 1..1647
FT /note="Maestro heat-like repeat-containing protein family
FT member 1"
FT /id="PRO_0000329403"
FT REPEAT 9..47
FT /note="HEAT 1"
FT REPEAT 65..103
FT /note="HEAT 2"
FT REPEAT 224..262
FT /note="HEAT 3"
FT REPEAT 351..389
FT /note="HEAT 4"
FT REPEAT 597..635
FT /note="HEAT 5"
FT REPEAT 968..1006
FT /note="HEAT 6"
FT REPEAT 1131..1168
FT /note="HEAT 7"
FT REPEAT 1364..1400
FT /note="HEAT 8"
FT REPEAT 1403..1441
FT /note="HEAT 9"
FT REPEAT 1490..1528
FT /note="HEAT 10"
FT REPEAT 1612..1647
FT /note="HEAT 11"
SQ SEQUENCE 1647 AA; 185562 MW; 16CD499480B6CDD7 CRC64;
MSKKNQQISP VLDNIVTSLL QSLSDSDESV RSTVVNSLYE IGFRQPNFVL QVACDYINKN
QKIDQTHRVK ILNSILQILE QTRNQLTDAL SLNLIAMSIS EMTRDKEVVP DWQQVASSLL
VSLGLRYPSQ IMDELLKRFE PGTLPHYFVM KTLGDFISSN PIPTVPKIRE ILSRILPVLG
TIKHDNFKWV FAAALGHFAD AIVQYVANID TAPDKSLTLY SFSSEFYPAL ELMFSKWLGT
NHEKVRLVTI EAVGSICSIL SVEQLESQIQ KLVVGVLSML KKEKDLLPVT HSLCCILEVC
VKNDLKLQVN ELLIPIMTTL HPLVCIVPDY SNPASTKTYN EVLRCFEVIG RGYSDVLISF
LNQRLENRDL RSRAGSLSII RHIVTRLDVE LADKKPLILS AIKPLIQTEP SLFIKKYLAQ
IIIAMAPYGY LEMEGGLTLL EFIVKGSSWY QDSEIGKAQP TQPPKKIENP DLHVTDSELR
LICDNILNLI TTTMPQLESI LWPYLFEFIL PEQYTAAIPV VTKSLTYIAL SKKSVDSDDY
YIDFDKEINL PKPTQIIARY FVLLTAPLRR NQLGIRILEN MKAIGPILHP SICDMWDVTL
PKLISYLEDH TDIETWNKNQ WEELVLRLLS ETIKNAADDE WTVALGNSMS EQIDHYKKDP
ILKRSLYKQM GLIMQKCSHK EFVKSKIEVM FTSVDYTNSL ENEGCAIGLG YCGASHFDIV
LEKINFYIKN SMVKKSGFFG KKGPKGIKNC ILLSLGYSAT YAQSALFSSR VEVHVIQPIK
PSILQLKKVP KKLSSIKMID LIGKALHPNK ASTFIFKQRD ELMKLLISYM STPPPSTNNQ
VKIDGTNACS TLVNLEPMIS LELEVQIINL SLSFFNQQVS PANATNTDSD EYKEVNSLIT
SVNNLLSTIL YNQTTIACLN RLIGYLDPLS RSKDAHIRER SLFCILYLVK KFIEYSTDSD
SMPTDKLFDS IGTTLSVLIP RCTDPEINVR RYAVESIQLI LYIGFMLKNA TPDNRRVKPS
EVLHPLTSIR DSITTTEVNE QFSLVFEISV IISKMISLEE IPKFLEGSIK GLQDLQAFST
NGSCIIINGL IKTRGEELIE YVPILVKGLL TAMEGITSET TMNGTLVSLR SLANHHLIPV
LSVLLEYPMP HSVHVIKSFQ IIAKDKNLIS PTLIHLMDLL NNKPVYEEKP DPKNKNRIIP
QPFAIALAAT CSLGEIFQLT EVEEVVKYFY HQLISTLVLR AGTCNNSLPC LIEVASTNPK
AKASAISLIP SQQMLVTFRQ FFKCTKEEET LLAEIESKGS FSQLETPFYH QGIIEILSVV
SSHHPDLIQG IFQYLLPYQR SNHLEHRIVT ISVTTELINH CKDKELIQRL INTLLNSLVD
PLVKLISLKG LSNIVSAGVE QTNRYAPTVI DALSTSIDDQ DETMAMECML GLSKIFEVAD
EGRVAPILVN ICNRIRPAFE KPNDSIRAAS FQLFGSLWRF GSGSACDPFY EQIHSSLPSL
IMHLNDDVQS VKNSCKKTLF QLSTLMRSQD AMDYFNNKSK GFVGDNDQPN YEEFLLDFSK
LLIINYPERV NYFVMTVIEF FKSTWVNLRG NAATFIGFIL GNLTEDKRTQ TNINSTILTK
SLVGLLAEKS PAVRKKAAES LGLLHHY
