MROH1_HUMAN
ID MROH1_HUMAN Reviewed; 1641 AA.
AC Q8NDA8; C9JWM5; D3DWL5; Q0P612; Q569G6; Q6NVW4; Q8N230; Q8NAD1; Q8ND95;
AC Q96JJ4;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Maestro heat-like repeat-containing protein family member 1;
DE AltName: Full=HEAT repeat-containing protein 7A;
GN Name=MROH1; Synonyms=HEATR7A, KIAA1833;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT VAL-38.
RC TISSUE=Brain;
RX PubMed=11347906; DOI=10.1093/dnares/8.2.85;
RA Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 8:85-95(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 384-1641 (ISOFORM 7), AND VARIANT VAL-38.
RC TISSUE=Spleen, and Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND VARIANT
RP VAL-38.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT VAL-38.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 6), AND VARIANT
RP VAL-38.
RC TISSUE=Blood, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=7;
CC Name=1;
CC IsoId=Q8NDA8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NDA8-2; Sequence=VSP_032974, VSP_032976, VSP_032977;
CC Name=3;
CC IsoId=Q8NDA8-3; Sequence=VSP_032963, VSP_032975, VSP_032978;
CC Name=4;
CC IsoId=Q8NDA8-4; Sequence=VSP_032968, VSP_032971;
CC Name=5;
CC IsoId=Q8NDA8-5; Sequence=VSP_032966, VSP_032967;
CC Name=6;
CC IsoId=Q8NDA8-6; Sequence=VSP_032965, VSP_032969, VSP_032970;
CC Name=7;
CC IsoId=Q8NDA8-7; Sequence=VSP_032972, VSP_032973;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH57824.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH67855.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH92486.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB47462.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAD38979.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB058736; BAB47462.1; ALT_INIT; mRNA.
DR EMBL; AK092861; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK093563; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL834309; CAD38979.1; ALT_INIT; mRNA.
DR EMBL; AL834145; CAD38858.1; -; mRNA.
DR EMBL; AC104592; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC145291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471162; EAW82134.1; -; Genomic_DNA.
DR EMBL; CH471162; EAW82137.1; -; Genomic_DNA.
DR EMBL; CH471162; EAW82143.1; -; Genomic_DNA.
DR EMBL; BC040742; AAH40742.1; -; mRNA.
DR EMBL; BC092486; AAH92486.1; ALT_INIT; mRNA.
DR EMBL; BC057824; AAH57824.1; ALT_INIT; mRNA.
DR EMBL; BC067855; AAH67855.1; ALT_INIT; mRNA.
DR CCDS; CCDS47938.1; -. [Q8NDA8-1]
DR CCDS; CCDS47939.1; -. [Q8NDA8-4]
DR RefSeq; NP_001092750.1; NM_001099280.2. [Q8NDA8-4]
DR RefSeq; NP_001092751.1; NM_001099281.2. [Q8NDA8-4]
DR RefSeq; NP_001275743.1; NM_001288814.1.
DR RefSeq; NP_115826.2; NM_032450.2. [Q8NDA8-1]
DR RefSeq; XP_011515587.1; XM_011517285.1. [Q8NDA8-2]
DR AlphaFoldDB; Q8NDA8; -.
DR BioGRID; 608397; 90.
DR IntAct; Q8NDA8; 2.
DR STRING; 9606.ENSP00000435565; -.
DR iPTMnet; Q8NDA8; -.
DR PhosphoSitePlus; Q8NDA8; -.
DR BioMuta; MROH1; -.
DR DMDM; 296439329; -.
DR EPD; Q8NDA8; -.
DR jPOST; Q8NDA8; -.
DR MassIVE; Q8NDA8; -.
DR MaxQB; Q8NDA8; -.
DR PaxDb; Q8NDA8; -.
DR PeptideAtlas; Q8NDA8; -.
DR PRIDE; Q8NDA8; -.
DR ProteomicsDB; 73000; -. [Q8NDA8-1]
DR ProteomicsDB; 73001; -. [Q8NDA8-2]
DR ProteomicsDB; 73002; -. [Q8NDA8-3]
DR ProteomicsDB; 73003; -. [Q8NDA8-4]
DR ProteomicsDB; 73004; -. [Q8NDA8-5]
DR ProteomicsDB; 73005; -. [Q8NDA8-6]
DR ProteomicsDB; 73006; -. [Q8NDA8-7]
DR Antibodypedia; 48391; 21 antibodies from 9 providers.
DR DNASU; 727957; -.
DR Ensembl; ENST00000326134.10; ENSP00000321737.5; ENSG00000179832.18. [Q8NDA8-1]
DR Ensembl; ENST00000423230.6; ENSP00000388174.2; ENSG00000179832.18. [Q8NDA8-4]
DR Ensembl; ENST00000528919.5; ENSP00000435565.1; ENSG00000179832.18. [Q8NDA8-1]
DR GeneID; 727957; -.
DR KEGG; hsa:727957; -.
DR MANE-Select; ENST00000326134.10; ENSP00000321737.5; NM_032450.3; NP_115826.3.
DR UCSC; uc003zbi.5; human. [Q8NDA8-1]
DR CTD; 727957; -.
DR DisGeNET; 727957; -.
DR GeneCards; MROH1; -.
DR HGNC; HGNC:26958; MROH1.
DR HPA; ENSG00000179832; Tissue enhanced (thyroid).
DR neXtProt; NX_Q8NDA8; -.
DR OpenTargets; ENSG00000179832; -.
DR PharmGKB; PA164720350; -.
DR VEuPathDB; HostDB:ENSG00000179832; -.
DR eggNOG; KOG2032; Eukaryota.
DR GeneTree; ENSGT00940000156930; -.
DR HOGENOM; CLU_753442_0_0_1; -.
DR InParanoid; Q8NDA8; -.
DR OMA; CENTLYM; -.
DR OrthoDB; 31329at2759; -.
DR PhylomeDB; Q8NDA8; -.
DR TreeFam; TF315201; -.
DR PathwayCommons; Q8NDA8; -.
DR SignaLink; Q8NDA8; -.
DR BioGRID-ORCS; 727957; 9 hits in 1069 CRISPR screens.
DR ChiTaRS; MROH1; human.
DR GenomeRNAi; 727957; -.
DR Pharos; Q8NDA8; Tdark.
DR PRO; PR:Q8NDA8; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q8NDA8; protein.
DR Bgee; ENSG00000179832; Expressed in right lobe of thyroid gland and 169 other tissues.
DR ExpressionAtlas; Q8NDA8; baseline and differential.
DR Genevisible; Q8NDA8; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR045206; Maestro_heat-like_prot.
DR PANTHER; PTHR23120; PTHR23120; 1.
DR Pfam; PF02985; HEAT; 1.
DR SUPFAM; SSF48371; SSF48371; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Repeat.
FT CHAIN 1..1641
FT /note="Maestro heat-like repeat-containing protein family
FT member 1"
FT /id="PRO_0000329402"
FT REPEAT 3..41
FT /note="HEAT 1"
FT REPEAT 159..198
FT /note="HEAT 2"
FT REPEAT 344..382
FT /note="HEAT 3"
FT REPEAT 385..423
FT /note="HEAT 4"
FT REPEAT 1048..1086
FT /note="HEAT 5"
FT REPEAT 1358..1396
FT /note="HEAT 6"
FT REPEAT 1605..1641
FT /note="HEAT 7"
FT VAR_SEQ 1..1038
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_032963"
FT VAR_SEQ 1..68
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032965"
FT VAR_SEQ 317..378
FT /note="ICVPVESSSPLVMSNQKEVLRCFTVLACSSPDRLLAFLLPRLDTSNERTRVG
FT TLQVVRHVIN -> VGGGRQGAGPGSAHPSVGSCWTRGAESKLGWMAQPRGAEDWAFPE
FT GHSGDFLAMWRCSCPAQ (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_032966"
FT VAR_SEQ 379..1641
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_032967"
FT VAR_SEQ 381..422
FT /note="AAQMEDKKPFILSSMRLPLLDTNSKVKRAVVQVISAMAHHGY -> GSTNTR
FT ITLMLPSAVTRLKHEDCPARAAPQPADLTAAPASVA (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032968"
FT VAR_SEQ 381..408
FT /note="AAQMEDKKPFILSSMRLPLLDTNSKVKR -> GECLHASLAATPGHVQDGAG
FT PGRLCPSK (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032969"
FT VAR_SEQ 409..1641
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032970"
FT VAR_SEQ 423..1641
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032971"
FT VAR_SEQ 592..610
FT /note="EHTEETLPQEEWEEKLLMF -> GEARVRMGCIALWGGQVSE (in
FT isoform 7)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_032972"
FT VAR_SEQ 611..1641
FT /note="Missing (in isoform 7)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_032973"
FT VAR_SEQ 774..782
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11347906"
FT /id="VSP_032974"
FT VAR_SEQ 1039..1040
FT /note="GQ -> MR (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_032975"
FT VAR_SEQ 1143..1156
FT /note="SHTCMLWRALAVEP -> RYPAQTPGLGVPLE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11347906"
FT /id="VSP_032976"
FT VAR_SEQ 1157..1641
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11347906"
FT /id="VSP_032977"
FT VAR_SEQ 1593..1641
FT /note="FLVLHSEPRQQPQVDLDQLIAALQILLKDPAPEVRTRAAEALGRLVKLA ->
FT KHHPLPHPHAARQPRLMPPLHRVPGAALGAQAAAAGGPGPAHCGAPDPAEGPGPRGADE
FT GC (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_032978"
FT VARIANT 38
FT /note="A -> V (in dbSNP:rs34819224)"
FT /evidence="ECO:0000269|PubMed:11347906,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:17974005, ECO:0000269|Ref.5"
FT /id="VAR_062166"
FT CONFLICT 70
FT /note="E -> K (in Ref. 2; AK093563)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1641 AA; 181249 MW; FD194A308C021254 CRC64;
MTESSMKKLA STLLDAITDK DPLVQEQVCS ALCSLGEARP VETLRACEEY LRQHDKLAHP
YRAAVLRAME RVLSSRASEL DKDTASTIIL LASSEMTKTK DLVWDWQQAA SGVLVAVGRQ
FISKVMEELL RRLHPGTLPH CAVLHTLASL SVANAFGVVP FLPSVLSSLL PVLGVAKQDT
VRVAFCSALQ RFSEGALEYL ANLDRAPDPT VRKDAFATDI FSAYDVLFHQ WLQSREAKLR
LAVVEALGPM SHLLPSERLE EQLPKLLPGI LALYKKHAET FYLSKSLGQI LEAAVSVGSR
TLETQLDALL AALHSQICVP VESSSPLVMS NQKEVLRCFT VLACSSPDRL LAFLLPRLDT
SNERTRVGTL QVVRHVINSA AAQMEDKKPF ILSSMRLPLL DTNSKVKRAV VQVISAMAHH
GYLEQPGGEA MIEYIVQQCA LPPEQEPEKP GPGSKDPKAD SVRAISVRTL YLVSTTVDRM
SHVLWPYLLQ FLTPVRFTGA LTPLCRSLVH LAQKRQEAGA DAFLIQYDAH ASLPSPYAVT
GRLLVVSSSP YLGDGRGAAA LRLLSVLHPN IHPLLGQHWE TTVPLLLGYL DEHTEETLPQ
EEWEEKLLMF LRDTLAIISD NAWICQLSLE LCRQLPCYDE APQEKNFLYK CIGTTLGAAS
SKEVVRKHLQ ELLETARYQE EAEREGLACC FGICAISHLE DTLAQLEDFV RSEVFRKSIG
ILNIFKDRSE NEVEKVKSAL ILCYGHVAAR APRELVLAKV ESDILRNICQ HFSTKVLGIK
VETKDPALKL CLVQSVCMVS RAICSSTQAG SFHFTRKAEL VAQMMEFIRA EPPDSLRTPI
RKKAMLTCTY LVSVEPALDE QARADVIHGC LHSIMALLPE PKEEDGGCQK SLYLETLHAL
EDLLTSLLQR NMTPQGLQIM IEHLSPWIKS PRGHERARAL GLSALLLRYF LEHLRVSALV
PFHNLGLLIG LFSPRCADLW PATRQEAVDC VYSLLYLQLG YEGFSRDYRD DVAERLLSLK
DGLVHPDPAI LFHTCHSVGQ IIAKRLPPDQ LISLLLTMFE ALGDPEKNCS RAATVMINCL
LQERGGVLQE KVPEIVSVLR SKLQEAQGEH VLPAAQHSVY LLATQHCAAV VSSLLGSPLP
LDSHTCMLWR ALAVEPRLAA QVLGLLLEKM SRDVPFKESR AFLLGRTPDR VATLLPLSAT
CALFEVMSTP AAGPAVLELY PQLFVVLLLR VSCTVGVQLP RNLQAQERRG ASPALATRNL
EPCSSAVDTL RSMLLRSGSE DVVQRMDLEG GWELLRTSAG HEEGATRLAR AMAEHAGPRL
PLVLKTLACT HSSAYENQRV TTTAFLAELL NSNVANDLML LDSLLESLAA RQKDTCASVR
RLVLRGLANL ASGCPDKVRT HGPQLLTAMI GGLDDGDNPH SPVALEAMLG LARLVHLVES
WDLRSGLLHV AIRIRPFFDS EKMEFRTASI RLFGHLNKVC HGDCEDVFLD QVVGGLAPLL
LHLQDPQATV ASACRFALRM CGPNLACEEL SAAFQKHLQE GRALHFGEFL NTTCKHLMHH
FPDLLGRLLT TCLFYFKSSW ENVRAAAPLF TGFLVLHSEP RQQPQVDLDQ LIAALQILLK
DPAPEVRTRA AEALGRLVKL A
