MROH5_HUMAN
ID MROH5_HUMAN Reviewed; 1318 AA.
AC Q6ZUA9;
DT 03-APR-2013, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2013, sequence version 2.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Maestro heat-like repeat family member 5;
GN Name=MROH5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
CC -!- CAUTION: MROH5 may be both a gene and a pseudogene in the human
CC population, the reference genome corresponding currently to the non-
CC functional allele with a stop codon at position 925. The sequence shown
CC here with a Gln at that position is the one of the functional protein.
CC {ECO:0000305}.
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DR EMBL; AK125848; BAC86317.1; -; mRNA.
DR EMBL; AC138647; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC100803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_997297.2; NM_207414.2.
DR AlphaFoldDB; Q6ZUA9; -.
DR BioGRID; 133232; 8.
DR iPTMnet; Q6ZUA9; -.
DR PhosphoSitePlus; Q6ZUA9; -.
DR BioMuta; MROH5; -.
DR DMDM; 476007234; -.
DR jPOST; Q6ZUA9; -.
DR PaxDb; Q6ZUA9; -.
DR PeptideAtlas; Q6ZUA9; -.
DR PRIDE; Q6ZUA9; -.
DR DNASU; 389690; -.
DR GeneID; 389690; -.
DR KEGG; hsa:389690; -.
DR CTD; 389690; -.
DR DisGeNET; 389690; -.
DR GeneCards; MROH5; -.
DR HGNC; HGNC:42976; MROH5.
DR neXtProt; NX_Q6ZUA9; -.
DR InParanoid; Q6ZUA9; -.
DR OrthoDB; 73302at2759; -.
DR PathwayCommons; Q6ZUA9; -.
DR SignaLink; Q6ZUA9; -.
DR BioGRID-ORCS; 389690; 5 hits in 193 CRISPR screens.
DR ChiTaRS; MROH5; human.
DR GenomeRNAi; 389690; -.
DR Pharos; Q6ZUA9; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q6ZUA9; protein.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045206; Maestro_heat-like_prot.
DR PANTHER; PTHR23120; PTHR23120; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat.
FT CHAIN 1..1318
FT /note="Maestro heat-like repeat family member 5"
FT /id="PRO_0000421988"
FT REPEAT 581..618
FT /note="HEAT 1"
FT REPEAT 769..811
FT /note="HEAT 2"
FT REPEAT 840..880
FT /note="HEAT 3"
FT REPEAT 996..1033
FT /note="HEAT 4"
FT REPEAT 1037..1074
FT /note="HEAT 5"
FT REPEAT 1076..1113
FT /note="HEAT 6"
FT REPEAT 1118..1155
FT /note="HEAT 7"
FT REPEAT 1164..1200
FT /note="HEAT 8"
FT REPEAT 1278..1315
FT /note="HEAT 9"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 676..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 8..10
FT /note="RPY -> KPH (in Ref. 1; BAC86317)"
FT /evidence="ECO:0000305"
FT CONFLICT 43
FT /note="K -> E (in Ref. 1; BAC86317)"
FT /evidence="ECO:0000305"
FT CONFLICT 74
FT /note="L -> P (in Ref. 1; BAC86317)"
FT /evidence="ECO:0000305"
FT CONFLICT 90
FT /note="G -> C (in Ref. 1; BAC86317)"
FT /evidence="ECO:0000305"
FT CONFLICT 289
FT /note="L -> M (in Ref. 1; BAC86317)"
FT /evidence="ECO:0000305"
FT CONFLICT 331
FT /note="L -> S (in Ref. 1; BAC86317)"
FT /evidence="ECO:0000305"
FT CONFLICT 725
FT /note="D -> N (in Ref. 1; BAC86317)"
FT /evidence="ECO:0000305"
FT CONFLICT 838
FT /note="G -> E (in Ref. 1; BAC86317)"
FT /evidence="ECO:0000305"
FT CONFLICT 985
FT /note="L -> P (in Ref. 1; BAC86317)"
FT /evidence="ECO:0000305"
FT CONFLICT 1088
FT /note="G -> S (in Ref. 1; BAC86317)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1318 AA; 149091 MW; 27B8287B7A98EB4F CRC64;
MDRQCSERPY SCTPTGRVSS AVSQNSRISP PVSTSMKDSS CMKVHQDSAR RDRWSHPTTI
LLHKSQSSQA TLMLQEHRMF MGEAYSAATG FKMLQDMNSA DPFHLKYIIK KIKNMAHGSP
KLVMETIHDY FIDNPEISSR HKFRLFQTLE MVIGASDVLE ETWEKTFTRL ALENMTKATE
LEDIYQDAAS NMLVAICRHS WRVVAQHLET ELLTGVFPHR SLLYVMGVLS SSEELFSQED
KACWEEQLIQ MAIKSVPFLS TDVWSKELLW TLTTPSWTQQ EQSPEKAFLF TYYGLILQAE
KNGATVRRHL QALLETSHQW PKQREGMALT LGLAATRHLD DVWAVLDQFG RSRPIRWSLP
SSSPKNSEDL RWKWASSTIL LAYGQVAAKA RAHILPWVDN IVSRMVFYFH YSSWDETLKQ
SFLTATLMLM GAVSRSEGAH SYEFFQTSEL LQCLMVLMEK EPQDTLCTRS RQQAMHIASS
LCKLRPPIDL ERKSQLLSTC FRSVFALPLL DALEKHTCLF LEPPNIQLWP VARERAGWTH
QGWGPRAVLH CSEHLQSLYS RTMEALDFML QSLIMQNPTA DELHFLLSHL YIWLASEKAH
ERQRAVHSCM ILLKFLNHNG YLDPKEDFKR IGQLVGILGM LCQDPDRATQ RCSLEGASHL
YQLLMCHKTG EALQAESQAP KELSQAHSDG APLWNSRDQK ATPLGPQEMA KNHIFQLCSF
QVIKDIMQQL TLAELSDLIW TAIDGLGSTS PFRVQAASEM LLTAVQEHGA KLEIVSSMAQ
AIRLRLCSVH IPQAKEKTLH AITLLARSHT CELVATFLNI SIPLDSHTFQ LWRALGAGQP
TSHLVLTTLL ACLQERPLPT GASDSSPCPK EKTYLRLLAA MNMLHELQFA REFKQAVQEG
YPKLFLALLT QMHYVLELNL PSEPQPKQQA QEAAVPSPQS CSTSLEALKS LLSTTGHWHD
FAHLELQGSW ELFTTIHTYP KGVGLLARAM VQNHCRQIPA VLRQLLPSLQ SPQERERKVA
ILILTKFLYS PVLLEVLPKQ AALTVLAQGL HDPSPEVRVL SLQGLSNILF HPDKGSLLQG
QLRPLLDGFF QSSDQVIVCI MGTVSDTLHR LGAQGTGSQS LGVAISTRSF FNDERDGIRA
AAMALFGDLV AAMADRELSG LRTQVHQSMV PLLLHLKDQC PAVATQAKFT FYRCAVLLRW
RLLHTLFCTL AWERGLSARH FLWTCLMTRS QEEFSIHLSQ ALSYLHSHSC HIKTWVTLFI
GHTICYHPQA VFQMLNAVDT NLLFRTFEHL RSDPEPSIRE FATSQLSFLQ KVSARPKQ
