MROH6_HUMAN
ID MROH6_HUMAN Reviewed; 719 AA.
AC A6NGR9; A8MWB1;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Maestro heat-like repeat-containing protein family member 6;
GN Name=MROH6; Synonyms=C8orf73;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
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DR EMBL; AC067930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS47928.1; -.
DR RefSeq; NP_001094348.1; NM_001100878.1.
DR AlphaFoldDB; A6NGR9; -.
DR BioGRID; 567998; 6.
DR IntAct; A6NGR9; 2.
DR STRING; 9606.ENSP00000381857; -.
DR iPTMnet; A6NGR9; -.
DR PhosphoSitePlus; A6NGR9; -.
DR BioMuta; MROH6; -.
DR EPD; A6NGR9; -.
DR jPOST; A6NGR9; -.
DR MassIVE; A6NGR9; -.
DR MaxQB; A6NGR9; -.
DR PaxDb; A6NGR9; -.
DR PeptideAtlas; A6NGR9; -.
DR PRIDE; A6NGR9; -.
DR ProteomicsDB; 1146; -.
DR Antibodypedia; 76664; 4 antibodies from 4 providers.
DR DNASU; 642475; -.
DR Ensembl; ENST00000398882.8; ENSP00000381857.3; ENSG00000204839.9.
DR Ensembl; ENST00000618551.2; ENSP00000479227.1; ENSG00000277781.2.
DR GeneID; 642475; -.
DR KEGG; hsa:642475; -.
DR MANE-Select; ENST00000398882.8; ENSP00000381857.3; NM_001100878.2; NP_001094348.1.
DR UCSC; uc010mff.4; human.
DR CTD; 642475; -.
DR DisGeNET; 642475; -.
DR GeneCards; MROH6; -.
DR HGNC; HGNC:27814; MROH6.
DR HPA; ENSG00000204839; Tissue enhanced (esophagus, skin).
DR neXtProt; NX_A6NGR9; -.
DR OpenTargets; ENSG00000204839; -.
DR PharmGKB; PA142672336; -.
DR VEuPathDB; HostDB:ENSG00000204839; -.
DR eggNOG; ENOG502SUFR; Eukaryota.
DR GeneTree; ENSGT00940000162472; -.
DR HOGENOM; CLU_030549_0_0_1; -.
DR InParanoid; A6NGR9; -.
DR OMA; GHVPNFL; -.
DR OrthoDB; 429115at2759; -.
DR PhylomeDB; A6NGR9; -.
DR TreeFam; TF343191; -.
DR PathwayCommons; A6NGR9; -.
DR SignaLink; A6NGR9; -.
DR BioGRID-ORCS; 642475; 25 hits in 1074 CRISPR screens.
DR ChiTaRS; MROH6; human.
DR GenomeRNAi; 642475; -.
DR Pharos; A6NGR9; Tdark.
DR PRO; PR:A6NGR9; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; A6NGR9; protein.
DR Bgee; ENSG00000204839; Expressed in lower esophagus mucosa and 98 other tissues.
DR ExpressionAtlas; A6NGR9; baseline and differential.
DR Genevisible; A6NGR9; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045206; Maestro_heat-like_prot.
DR PANTHER; PTHR23120; PTHR23120; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 4: Predicted;
KW Reference proteome; Repeat.
FT CHAIN 1..719
FT /note="Maestro heat-like repeat-containing protein family
FT member 6"
FT /id="PRO_0000320922"
FT REPEAT 356..393
FT /note="HEAT 1"
FT REPEAT 397..434
FT /note="HEAT 2"
FT REPEAT 436..473
FT /note="HEAT 3"
FT REPEAT 477..514
FT /note="HEAT 4"
FT REPEAT 527..563
FT /note="HEAT 5"
FT REPEAT 594..631
FT /note="HEAT 6"
FT REPEAT 633..674
FT /note="HEAT 7"
FT REGION 25..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 97
FT /note="H -> Q (in dbSNP:rs4873803)"
FT /id="VAR_039305"
FT VARIANT 132
FT /note="V -> A (in dbSNP:rs4874153)"
FT /id="VAR_039306"
FT VARIANT 134
FT /note="T -> I (in dbSNP:rs10866911)"
FT /id="VAR_039307"
FT VARIANT 619
FT /note="A -> T (in dbSNP:rs13255489)"
FT /id="VAR_061595"
SQ SEQUENCE 719 AA; 77186 MW; E934473EF64302AC CRC64;
MAGGVWGRSR AREAPVGALT LTALTEGIRA RQGQPQGPPS AGPQPKSWEV KPEAEPQTQA
LTAPSEAEPG RGATVPEAGS EPCSLNSALE PAPEGPHQVP QSSWEEGVLA DLALYTAACL
EEAGFAGTQA TVLTLSSALE ARGERLEDQV HALVRGLLAQ VPSLAEGRPW RAALRVLSAL
ALEHARDVVC ALLPRSLPAD RVAAELWRSL SRNQRVNGQV LVQLLWALKG ASGPEPQALA
ATRALGEMLA VSGCVGATRG FYPHLLLALV TQLHKLARSP CSPDMPKIWV LSHRGPPHSH
ASCAVEALKA LLTGDGGRMV VTCMEQAGGW RRLVGAHTHL EGVLLLASAM VAHADHHLRG
LFADLLPRLR SADDPQRLTA MAFFTGLLQS RPTARLLREE VILERLLTWQ GDPEPTVRWL
GLLGLGHLAL NRRKVRHVST LLPALLGALG EGDARLVGAA LGALRRLLLR PRAPVRLLSA
ELGPRLPPLL DDTRDSIRAS AVGLLGTLVR RGRGGLRLGL RGPLRKLVLQ SLVPLLLRLH
DPSRDAAESS EWTLARCDHA FCWGLLEELV TVAHYDSPEA LSHLCCRLVQ RYPGHVPNFL
SQTQGYLRSP QDPLRRAAAV LIGFLVHHAS PGCVNQDLLD SLFQDLGRLQ SDPKPAVAAA
AHVSAQQVAM LARARGCPRG PRLLRIAPRP ARPPPVFADS PFQRRSVAGR WGCSGPRRA
