MROH7_HUMAN
ID MROH7_HUMAN Reviewed; 1323 AA.
AC Q68CQ1; A0AUX8; Q5TA99; Q6ZP40; Q6ZRH6; Q8N311; Q8NA14;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 4.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Maestro heat-like repeat-containing protein family member 7;
DE AltName: Full=HEAT repeat-containing protein 8;
GN Name=MROH7; Synonyms=C1orf175, HEATR8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 989-1323 (ISOFORM 1), AND VARIANTS ARG-182;
RP PHE-312; GLY-316 AND ARG-618.
RC TISSUE=Kidney, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), AND VARIANTS ASP-306;
RP GLY-316; ALA-509 AND ARG-618.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 827-1323 (ISOFORM 5), AND VARIANTS ARG-182; GLY-316
RP AND ARG-618.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP VARIANT [LARGE SCALE ANALYSIS] TYR-183.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q68CQ1-7; Sequence=Displayed;
CC Name=2;
CC IsoId=Q68CQ1-2; Sequence=VSP_037030, VSP_037031;
CC Name=3;
CC IsoId=Q68CQ1-8; Sequence=VSP_037028, VSP_037029;
CC Name=4;
CC IsoId=Q68CQ1-4; Sequence=VSP_037025, VSP_037026;
CC Name=5;
CC IsoId=Q68CQ1-9; Sequence=VSP_037032;
CC Name=6;
CC IsoId=Q68CQ1-1; Sequence=VSP_037024, VSP_037027, VSP_037033;
CC -!- MISCELLANEOUS: [Isoform 6]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC87334.1; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305};
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DR EMBL; AK093272; BAC04116.1; -; mRNA.
DR EMBL; AK128221; BAC87334.1; ALT_SEQ; mRNA.
DR EMBL; AK130047; BAC85285.1; -; mRNA.
DR EMBL; CR749830; CAH18687.1; -; mRNA.
DR EMBL; AL139244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590093; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC029191; AAH29191.1; -; mRNA.
DR EMBL; BC126126; AAI26127.1; -; mRNA.
DR CCDS; CCDS41342.2; -. [Q68CQ1-7]
DR RefSeq; NP_001034553.2; NM_001039464.3. [Q68CQ1-7]
DR AlphaFoldDB; Q68CQ1; -.
DR BioGRID; 131944; 3.
DR STRING; 9606.ENSP00000396622; -.
DR GlyGen; Q68CQ1; 3 sites.
DR iPTMnet; Q68CQ1; -.
DR PhosphoSitePlus; Q68CQ1; -.
DR BioMuta; MROH7; -.
DR DMDM; 317373558; -.
DR MassIVE; Q68CQ1; -.
DR PaxDb; Q68CQ1; -.
DR PeptideAtlas; Q68CQ1; -.
DR PRIDE; Q68CQ1; -.
DR ProteomicsDB; 66014; -. [Q68CQ1-7]
DR ProteomicsDB; 66015; -. [Q68CQ1-1]
DR ProteomicsDB; 66016; -. [Q68CQ1-2]
DR ProteomicsDB; 66018; -. [Q68CQ1-8]
DR ProteomicsDB; 66019; -. [Q68CQ1-9]
DR Antibodypedia; 49795; 30 antibodies from 10 providers.
DR DNASU; 374977; -.
DR Ensembl; ENST00000395690.6; ENSP00000379044.2; ENSG00000184313.20. [Q68CQ1-2]
DR Ensembl; ENST00000413188.5; ENSP00000394373.1; ENSG00000184313.20. [Q68CQ1-8]
DR Ensembl; ENST00000421030.7; ENSP00000396622.2; ENSG00000184313.20. [Q68CQ1-7]
DR Ensembl; ENST00000422659.5; ENSP00000388181.1; ENSG00000184313.20. [Q68CQ1-8]
DR Ensembl; ENST00000438846.5; ENSP00000404780.1; ENSG00000184313.20. [Q68CQ1-8]
DR GeneID; 374977; -.
DR KEGG; hsa:374977; -.
DR MANE-Select; ENST00000421030.7; ENSP00000396622.2; NM_001039464.4; NP_001034553.3.
DR UCSC; uc001cxr.2; human. [Q68CQ1-7]
DR CTD; 374977; -.
DR DisGeNET; 374977; -.
DR GeneCards; MROH7; -.
DR HGNC; HGNC:24802; MROH7.
DR HPA; ENSG00000184313; Tissue enriched (testis).
DR neXtProt; NX_Q68CQ1; -.
DR OpenTargets; ENSG00000184313; -.
DR OpenTargets; ENSG00000271723; -.
DR PharmGKB; PA142672423; -.
DR VEuPathDB; HostDB:ENSG00000184313; -.
DR eggNOG; KOG2032; Eukaryota.
DR GeneTree; ENSGT00940000161775; -.
DR HOGENOM; CLU_003474_0_0_1; -.
DR InParanoid; Q68CQ1; -.
DR OMA; TIFKGQD; -.
DR OrthoDB; 31329at2759; -.
DR PhylomeDB; Q68CQ1; -.
DR TreeFam; TF337538; -.
DR PathwayCommons; Q68CQ1; -.
DR BioGRID-ORCS; 374977; 19 hits in 1068 CRISPR screens.
DR ChiTaRS; MROH7; human.
DR GenomeRNAi; 374977; -.
DR Pharos; Q68CQ1; Tdark.
DR PRO; PR:Q68CQ1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q68CQ1; protein.
DR Bgee; ENSG00000184313; Expressed in right testis and 94 other tissues.
DR ExpressionAtlas; Q68CQ1; baseline and differential.
DR Genevisible; Q68CQ1; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045206; Maestro_heat-like_prot.
DR PANTHER; PTHR23120; PTHR23120; 1.
DR SUPFAM; SSF48371; SSF48371; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..1323
FT /note="Maestro heat-like repeat-containing protein family
FT member 7"
FT /id="PRO_0000286866"
FT TRANSMEM 593..613
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 767..787
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 957..995
FT /note="HEAT 1"
FT REPEAT 1036..1074
FT /note="HEAT 2"
FT REPEAT 1079..1117
FT /note="HEAT 3"
FT REPEAT 1125..1162
FT /note="HEAT 4"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 66..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 318
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 438
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 586
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 410
FT /note="E -> EDGVSLLLPRLECNGAISAHCNLCLP (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_037024"
FT VAR_SEQ 412..421
FT /note="AFDEVTSCLV -> VSGSSWTFPA (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_037025"
FT VAR_SEQ 422..1323
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_037026"
FT VAR_SEQ 600
FT /note="F -> FIAIQT (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_037027"
FT VAR_SEQ 601..627
FT /note="MPLGFPALGLLLGRLILHIGDPDEEIG -> IAIQTDALGVPGAGASAGETH
FT PSHWGS (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_037028"
FT VAR_SEQ 628..1323
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_037029"
FT VAR_SEQ 989..1030
FT /note="LLQMEQVRRIPEEYSLGRMAEGLSHHDPIMKVLSIRGLVILA -> QPCEEG
FT IVILMLRPQDLMGKATTSSHRGSELESDTLSFATWC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_037030"
FT VAR_SEQ 1031..1323
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_037031"
FT VAR_SEQ 1148
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_037032"
FT VAR_SEQ 1223..1323
FT /note="GSLVPCMESIMTEDRLNEVKAALDNLRHDPEASVCIYAAQVQDHILASCWQN
FT SWLPHGNSWVCYSATTHRWSPSCENLPTSHQRRSWIMQALGSWKMSLKK -> ATPRGQ
FT RFHLPCPPLYSQPLEQAGSAERAKNLKRSPYL (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_037033"
FT VARIANT 182
FT /note="H -> R (in dbSNP:rs11206407)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_032218"
FT VARIANT 183
FT /note="S -> Y (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035495"
FT VARIANT 290
FT /note="V -> M (in dbSNP:rs12094920)"
FT /id="VAR_032219"
FT VARIANT 306
FT /note="Y -> D (in dbSNP:rs1655519)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_032220"
FT VARIANT 312
FT /note="S -> F (in dbSNP:rs17399810)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_032221"
FT VARIANT 316
FT /note="E -> G (in dbSNP:rs1655518)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005"
FT /id="VAR_032222"
FT VARIANT 352
FT /note="T -> M (in dbSNP:rs12074499)"
FT /id="VAR_032223"
FT VARIANT 455
FT /note="K -> R (in dbSNP:rs2304314)"
FT /id="VAR_055042"
FT VARIANT 509
FT /note="V -> A (in dbSNP:rs480963)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_055043"
FT VARIANT 618
FT /note="H -> R (in dbSNP:rs570218)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005"
FT /id="VAR_055044"
FT CONFLICT 583
FT /note="V -> A (in Ref. 1; BAC85285)"
FT /evidence="ECO:0000305"
FT CONFLICT 1099
FT /note="V -> D (in Ref. 2; CAH18687, 1; BAC87334 and 4;
FT AAH29191)"
FT /evidence="ECO:0000305"
FT CONFLICT 1155
FT /note="R -> C (in Ref. 1; BAC87334)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1323 AA; 145647 MW; 77CB3B2A21D545AA CRC64;
MALSPGANLV FHEDPKMTPS PPSCGAPGLG SGTIPQPHPD MAQVPMLNLL PSPGLALVPD
LNDSLSPVSG EASGLVSENT PRPDDSRAIA PASLQITSSC SGEALDLDSK DVSRPDSQGR
LCPASNPILS PSSTEAPRLS SGNHPQSNSE DAFKCLSSKI FKLGQRNSNP SRHELNPFIR
HHSREGLVLG HCISRPSSKA LLIPTSNSSL DLDSNPLLNM GSRNTSKLNL NVAPDSHGTL
IPDTNETITL ASHNISESVS KGAFSTTWST SSKETMNVAS SGHSRSDLSV TITQASYVTL
IPGSSYGISL HSSTHEPNST ISPPSCMTLI LGSNETLSLD SSLLFSDTST LTLSSQQDDA
KDNSIHTVPL EENLESWSEM ASIKVGQFPL GFPISNPAGK DAVTLQGIPE GAFDEVTSCL
VKVPEKTEGG NNMALVENVT TLQKSQDLLE AEGEKKTMIK KIMRQIQEEP LDSLSSSVRK
QAMEILTQLS HTQPTLGMRE RSELVNVCVH SVFSLPSVQA MQEKDEAKAE TIQALYHQTL
EALQTLLKAL FIEDPTPAGL KSILEALGPW MNSGKAHERA RAVNTNVSVL NHMLLTLPFF
MPLGFPALGL LLGRLILHIG DPDEEIGCEA LDGIIILYTI LELQKRARDK EETNKKELYE
SNKHFLGPYN PVSPCQNILR VIEEFGDFLG PQQIKDLLLA ALEGLKGSSE APGKDSREMM
QLASEVMLSS VLEWYRHRAL EVIPEIMQGI YMQLSHIQEP RARQVALLPV SLLASSFMTE
VVVALLMCPL PLNSNGAEMW RQLILCKPSC DVRDLLDLLL GSLKEKPVTK EGRASIVPLA
AASGLCELLS VNSCMGRVRR IYPQLLLALL IQVHYHIGLN LPGCVAPPKD TKKGAQPSPF
VPVRWVVKVV KTLLLRMGCS YETTFLEDQG GWELMEQVES HHRGVALLAR AMVQYSCQEL
CRILYLLIPL LERGDEKHRI TATAFFVELL QMEQVRRIPE EYSLGRMAEG LSHHDPIMKV
LSIRGLVILA RRSEKTAKVK ALLPSMVKGL KNMDGMLVVE AVHNLKAVFK GRDQKLMDSA
VYVEMLQILL PHFSDAREVV RSSCINLYGK VVQKLRAPRT QAMEEQLVST LVPLLLTMQE
GNSKVSQKCV KTLLRCSYFM AWELPKRAYS RKPWDNQQQT VAKICKCLVN THRDSAFIFL
SQSLEYAKNS RASLRKCSVM FIGSLVPCME SIMTEDRLNE VKAALDNLRH DPEASVCIYA
AQVQDHILAS CWQNSWLPHG NSWVCYSATT HRWSPSCENL PTSHQRRSWI MQALGSWKMS
LKK
