MROH7_MOUSE
ID MROH7_MOUSE Reviewed; 1279 AA.
AC A2AVR2;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Maestro heat-like repeat-containing protein family member 7;
DE AltName: Full=HEAT repeat-containing protein 8;
GN Name=Mroh7; Synonyms=Gm1027, Heatr8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AL929585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS51253.1; -.
DR RefSeq; NP_001119959.1; NM_001126487.1.
DR RefSeq; XP_006503264.1; XM_006503201.1.
DR RefSeq; XP_011238863.1; XM_011240561.2.
DR RefSeq; XP_011238864.1; XM_011240562.1.
DR AlphaFoldDB; A2AVR2; -.
DR STRING; 10090.ENSMUSP00000102382; -.
DR GlyGen; A2AVR2; 6 sites.
DR iPTMnet; A2AVR2; -.
DR PhosphoSitePlus; A2AVR2; -.
DR PaxDb; A2AVR2; -.
DR PRIDE; A2AVR2; -.
DR ProteomicsDB; 291408; -.
DR Ensembl; ENSMUST00000106770; ENSMUSP00000102382; ENSMUSG00000047502.
DR GeneID; 381538; -.
DR KEGG; mmu:381538; -.
DR UCSC; uc012dia.1; mouse.
DR CTD; 374977; -.
DR MGI; MGI:2685873; Mroh7.
DR VEuPathDB; HostDB:ENSMUSG00000047502; -.
DR eggNOG; KOG2032; Eukaryota.
DR GeneTree; ENSGT00940000161775; -.
DR HOGENOM; CLU_003474_0_0_1; -.
DR InParanoid; A2AVR2; -.
DR OMA; TIFKGQD; -.
DR OrthoDB; 31329at2759; -.
DR PhylomeDB; A2AVR2; -.
DR TreeFam; TF337538; -.
DR BioGRID-ORCS; 381538; 4 hits in 73 CRISPR screens.
DR ChiTaRS; Mroh7; mouse.
DR PRO; PR:A2AVR2; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; A2AVR2; protein.
DR Bgee; ENSMUSG00000047502; Expressed in testis and 46 other tissues.
DR ExpressionAtlas; A2AVR2; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045206; Maestro_heat-like_prot.
DR PANTHER; PTHR23120; PTHR23120; 1.
DR SUPFAM; SSF48371; SSF48371; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..1279
FT /note="Maestro heat-like repeat-containing protein family
FT member 7"
FT /id="PRO_0000286867"
FT TRANSMEM 548..568
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 722..742
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 913..950
FT /note="HEAT 1"
FT REPEAT 992..1029
FT /note="HEAT 2"
FT REPEAT 1035..1072
FT /note="HEAT 3"
FT REPEAT 1080..1117
FT /note="HEAT 4"
FT REGION 1..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 356
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A2RUW0"
FT CARBOHYD 200
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 210
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 255
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 267
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 296
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 541
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1279 AA; 141710 MW; 651202D41142A38D CRC64;
MALSRGTSLI LHEDPEKIPS PNSCEVPGIM SNTTPRPTPD LALAPPPEHA LALTPALHPA
LSPDPEGVSG PVSNDIPSHN ASGATTPSST QINTVDTADQ GLNHTSGPDA AGTLCPDSQP
ARIPSSTQAN VLSPENSSRP CSEDVSKSFS SKVFGLGQSN SNPSRPEPNL YIKALSREAL
VRSHNISRQG SQVPLLLPSN TSLDRLHSGN ISKVNLGIAP NSNEAITLTS HTIFASISKE
ALSAPWNTGS KGSINGTSTI QPRSGLNVTV THASHVSMIP GSSEGLSLQS SARVPNSTLS
PSSCMTLIMD SESPSMDSSF LVTDTSTLTL SSHRDYSEDN SIRTMPLEEN LGKWDSLQGV
TALQSPPEGT SEDVKVNEAE KRNHDNKAAL VANIITYQKN QEMVEMKEEK EATVKMMMRQ
IQEEPLDSLL SPARRQAMEI LAQLSHTKPI LSVRERVELV NTCVRSVFSL PSVQAMQEKD
ESKAEVIQIL YYQTLDSLQK LLNALFIEDP TPTGLKSILE PLGPWMNSGK AHERARAVNS
NVSVLNHTLV TLPFLISSGF PTLGLLLGRL LLRIGDPDEE IGREALDGIT ILYTILDLQK
RTKNKEDTNK KELYENNKRF LGPYNPVSPC QNILRVIAEF GDFLGPQQVR DLLLAALEGL
KGISETQGKD SGEMMQLASE VMLSSVLEWY RHRALEVIPE IMQGIYMQLT HIQEPRAREV
ALLPISFLAS SFMTEVVVAL LMCPLPLDSN GAEMWRQLIL RKPSCDVRDL LDLLLTSLKE
KPVTKKGRAS IVPLAAASGL CELLSVNSCV GRVRRIYPQL LLALLIQVHY HIGLNLPSRM
APRKDSKDDT QPPLFIPVRW MVKVVKTLLL KMGCSYESAF LEEQGGWELM GQAESHYRGV
SLLARAMVHY SCQELCRILY LLIPLLERGD ERHKITATAF FVELFRMEQV RRIPEEYSLG
RMVEGLSHRD PIMNVLSIRG LVILACKSEK MAKVQSLLPS MVKSLKNMDG MLVVEAVHDL
KRIFKGQGKK LTDSAVYVEM LQILLPHFTD AREMVRASCI NVYGKVVKKL QTPRTQAMEE
QLTSTLMPLL FIIQEGNAKV SQKCVKTLVC CSSFMNWELP KKAYSQKPWD NQQLTVTKIC
KYLVSSHRDN VFTFLNQSLE YAKNSRASLR KSSVIFIGSL VPCMENMMTE ERLNEVKATL
EILRHDPEAS VCICAAQAQD QIMATCWRNS WPLLYGDSWV CDPSSMHRWS PSCENLPTSH
QRRSWIMQAL ASWKMSLKQ
