MROH7_RAT
ID MROH7_RAT Reviewed; 1122 AA.
AC A2RUW0;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Maestro heat-like repeat-containing protein family member 7;
DE AltName: Full=HEAT repeat-containing protein 8;
GN Name=Mroh7; Synonyms=Heatr8;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; BC133066; AAI33067.1; -; mRNA.
DR RefSeq; NP_001094435.1; NM_001100965.2.
DR AlphaFoldDB; A2RUW0; -.
DR STRING; 10116.ENSRNOP00000054237; -.
DR GlyGen; A2RUW0; 7 sites.
DR iPTMnet; A2RUW0; -.
DR PhosphoSitePlus; A2RUW0; -.
DR PaxDb; A2RUW0; -.
DR Ensembl; ENSRNOT00000089934; ENSRNOP00000072770; ENSRNOG00000058870.
DR GeneID; 298301; -.
DR KEGG; rno:298301; -.
DR UCSC; RGD:1563440; rat.
DR CTD; 374977; -.
DR RGD; 1563440; Mroh7.
DR eggNOG; KOG2032; Eukaryota.
DR GeneTree; ENSGT00940000161775; -.
DR HOGENOM; CLU_003474_0_0_1; -.
DR InParanoid; A2RUW0; -.
DR OMA; TIFKGQD; -.
DR OrthoDB; 31329at2759; -.
DR PhylomeDB; A2RUW0; -.
DR TreeFam; TF337538; -.
DR PRO; PR:A2RUW0; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000058870; Expressed in testis and 12 other tissues.
DR Genevisible; A2RUW0; RN.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045206; Maestro_heat-like_prot.
DR PANTHER; PTHR23120; PTHR23120; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..1122
FT /note="Maestro heat-like repeat-containing protein family
FT member 7"
FT /id="PRO_0000286868"
FT TRANSMEM 548..568
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 722..742
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 913..950
FT /note="HEAT 1"
FT REPEAT 992..1029
FT /note="HEAT 2"
FT REPEAT 1035..1072
FT /note="HEAT 3"
FT REPEAT 1080..1117
FT /note="HEAT 4"
FT REGION 1..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..385
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 356
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT CARBOHYD 200
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 210
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 255
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 267
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 296
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 541
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 546
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1122 AA; 123859 MW; 8BB49373A42A4BD5 CRC64;
MALSRGTSLI LHEDPEKTPS PNSCEVPGIM SNTTPRPTPD LTLAPLPAHG VALAPALHPA
LSPDPEGVSG PVPNDISNPN ASGAATPSSI QINTADTDDQ SLDHTPKPNL AGTLCPDSQP
VPSLSSTQAT VLSPENSIKP LSEDIPKSFS SKVFGLGQSN SNPSRPEPNL YIRALSREAL
VRSHTISRQS SQTPLLLPSN TSLDRLHSGN ISKVNLGRAQ NSNEAITLTS HTIFASVSKE
ALSASWNTGS KGSVNVTSNS QPRSGLNVTV THASHVSLIP GSSEGLSLHS SAQVPNSTLS
PSSCMTLIMG SESLSMDSSF VVTDTSTLTL SSHRDYSEDN SIRTMPLEEN LGKWDSLQGV
TAFRSPPEGT SEDAKANESE KRDHDNDTAL VENIISYQKN QDEVEVTGEK ETTVKMMMRK
IQEEPLDSLL SPARRQAMEI LAQLSHTKPI LSVRERVELV NTCVRSVFSL PSVQAMQEKD
ESKAEVIQTL YHQTLDSLQK LLNALFIEDP TPAGLKSILE PLGPWMNSGK VHERARAVNS
NVSVLNYTLV TLPFFVSSGF PTLGLLLGRL LLRIGDPDEE IGREALDGIT ILYTILDLQK
RTKNKEEINK KELYETNKRF LGPYNPASPC QNILRVIAEF GDFLGPQQVR DLLLAALEGL
KDISETQGKD SIEMMQLASE VMLSSVLEWY RHRALEVIPE IMQGIYMQLS HIQEPRAREV
ALLPISFLAS SFMTEVVVAL LMCPLPLDSN GAEMWRQLIL RKPSCDVRDL LDLLLTSLKE
KPVTKKGRAS IVPLAAASGL CELLSVNSCV GRVRRIYPQL LLALLIQVHY HIGLNLPSRV
APRKDSKDDI QPPLFVPVRW MVKVVKTLLL KMGCSYESAF LEEQGGWELM GQAESHYRAV
SLLARAMVHY SCQELCRILY LLIPLLERGD ERHKITATAF FVELFRMEQV RRIPEEYSLG
RMVEGLSHRD PIMKVLSIRG LVILARRSEK MTKVQGLLPS MVKSLKNMDG VLVMEAVHDL
KTIFKGQAKK LTDNSVYIEM LQTLLPHFID ARETVRTSCI NTYGKVVKKL RMPRTQAMEE
QLTSTLMPLL FIIQEGNAKV SQHFPLEFHT AGIFFLLVCR NV
