MROH8_HUMAN
ID MROH8_HUMAN Reviewed; 483 AA.
AC Q9H579; Q5JYQ6;
DT 01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2003, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Protein MROH8;
DE AltName: Full=Maestro heat-like repeat-containing protein family member 8;
GN Name=MROH8; Synonyms=C20orf131, C20orf132;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 208-483 (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9H579-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H579-2; Sequence=VSP_003821, VSP_003822;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC04162.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK093432; BAC04162.1; ALT_INIT; mRNA.
DR EMBL; AL031659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL136172; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL833864; CAD38722.1; -; mRNA.
DR RefSeq; NP_689716.4; NM_152503.5.
DR RefSeq; NP_998796.1; NM_213631.2.
DR RefSeq; NP_998797.2; NM_213632.2.
DR AlphaFoldDB; Q9H579; -.
DR BioGRID; 126660; 4.
DR STRING; 9606.ENSP00000339971; -.
DR iPTMnet; Q9H579; -.
DR BioMuta; MROH8; -.
DR DMDM; 28201794; -.
DR MassIVE; Q9H579; -.
DR PeptideAtlas; Q9H579; -.
DR PRIDE; Q9H579; -.
DR ProteomicsDB; 80896; -. [Q9H579-2]
DR DNASU; 140699; -.
DR GeneID; 140699; -.
DR KEGG; hsa:140699; -.
DR UCSC; uc061wux.1; human. [Q9H579-1]
DR CTD; 140699; -.
DR DisGeNET; 140699; -.
DR GeneCards; MROH8; -.
DR HGNC; HGNC:16125; MROH8.
DR neXtProt; NX_Q9H579; -.
DR PharmGKB; PA25674; -.
DR eggNOG; KOG2032; Eukaryota.
DR InParanoid; Q9H579; -.
DR OrthoDB; 31329at2759; -.
DR PhylomeDB; Q9H579; -.
DR PathwayCommons; Q9H579; -.
DR BioGRID-ORCS; 140699; 10 hits in 266 CRISPR screens.
DR ChiTaRS; MROH8; human.
DR GeneWiki; C20orf132; -.
DR GenomeRNAi; 140699; -.
DR Pharos; Q9H579; Tdark.
DR PRO; PR:Q9H579; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9H579; protein.
DR Genevisible; Q9H579; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045206; Maestro_heat-like_prot.
DR PANTHER; PTHR23120; PTHR23120; 2.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..483
FT /note="Protein MROH8"
FT /id="PRO_0000079462"
FT VAR_SEQ 331..381
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_003821"
FT VAR_SEQ 481..483
FT /note="VSP -> ATDALYEVFLGNRLRAATFRLFPQLLMTLLIQIHHSIGLTMSDVD
FT IPSGLYTEQEVPSEVTPLCFAMQATKTLLLRTCCLQEFNIMEKNKGWALLGGKDGHLQG
FT LFLLANALLERNQLLAQKVMYLLVPLLNRGNDKHKLTSAGSFVELLRSPVAKRLPSIYS
FT VARFKDWLQDGNHLFRILGLRGLYNLVGHQEMREDIKSLLPYIVDSLRETDEKIVLSAI
FT QILLQLVRTMDFTTLAAMMRTLFSLFGDVRSDVHRFSVTLFGAAIKSVKNPDKKSIENQ
FT VLDSLVPLLLYSQDENDAVAEESRQVLTICAQFLKWKLPQEVYSKDPWHIKPTEAGTIC
FT RFFEKKCKGKINILEQTLMYSKNPKLPIRRSAVLFVGLLSKYMDHNELRRMGTDWIEDD
FT LRDLLCDPEPSLCIIASQTLLLVQMARAEPKPKQRVNWLQKLMGRSSA (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_003822"
FT CONFLICT 354
FT /note="T -> N (in Ref. 1; BAC04162)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 483 AA; 54816 MW; 1B1F8EC547A88352 CRC64;
MSSKHRICSQ EEVVIPCAYD SDSESVDLEL SNLEIIKKGS SSIELTDLDI PDIPGLHCEP
LSHSPRHLTQ QDPLSEAIVE KLIQSIQKVF NGELKGELEK LKFLGDLSSL SQALPYDETA
KSFIHSHIAD IVHTLNVLVQ EERPHSLSSS MRQEVFVTIA DLSYQDVHLL LGSEDRAELF
SLTIKSIITL PSVRTLTQIQ EIMPNGTCNT ECLYRQTFQA FSEMLQSLVV KDPHLENLDT
IIKLPLRFQR LGHLVALMAL LCGDPQEKVA EEAAEGIHSL LHITLRLKYI THDKKDQQNL
KRALTKCREF LELHSSAAKC FYNCPFRIAQ VFEGFLDSNE LCQFIMTTFD TLKTLKHPCI
QRSAGELLLT LAKNTESQFE KVPEIMGVIC AQLSIISQPR VRQQIINTVS LFISRPKYTD
IVLSFLLCHP VPYNRHLAEV WRMLSVELPS TTWILWRLLR KLQKCHNEPA QEKMAYVAVA
VSP
