MROH9_HUMAN
ID MROH9_HUMAN Reviewed; 573 AA.
AC Q5TGP6; A0PJM0; A0PJM2; F5GWX6; Q9H5D7;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Maestro heat-like repeat-containing protein family member 9;
GN Name=MROH9; Synonyms=C1orf129;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-524.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5TGP6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5TGP6-2; Sequence=VSP_047654;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB15690.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK027203; BAB15690.1; ALT_FRAME; mRNA.
DR EMBL; AL031965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX284613; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC113390; AAI13391.1; -; mRNA.
DR EMBL; BC113392; AAI13393.1; -; mRNA.
DR CCDS; CCDS41436.1; -. [Q5TGP6-1]
DR CCDS; CCDS53429.1; -. [Q5TGP6-2]
DR RefSeq; NP_001157101.1; NM_001163629.1. [Q5TGP6-2]
DR RefSeq; NP_079339.2; NM_025063.2. [Q5TGP6-1]
DR AlphaFoldDB; Q5TGP6; -.
DR BioGRID; 123132; 2.
DR STRING; 9606.ENSP00000356733; -.
DR iPTMnet; Q5TGP6; -.
DR PhosphoSitePlus; Q5TGP6; -.
DR BioMuta; MROH9; -.
DR DMDM; 74746511; -.
DR PaxDb; Q5TGP6; -.
DR PeptideAtlas; Q5TGP6; -.
DR PRIDE; Q5TGP6; -.
DR Antibodypedia; 34373; 54 antibodies from 8 providers.
DR DNASU; 80133; -.
DR Ensembl; ENST00000367758.7; ENSP00000356732.3; ENSG00000117501.15. [Q5TGP6-1]
DR Ensembl; ENST00000367759.9; ENSP00000356733.4; ENSG00000117501.15. [Q5TGP6-2]
DR GeneID; 80133; -.
DR KEGG; hsa:80133; -.
DR MANE-Select; ENST00000367759.9; ENSP00000356733.4; NM_001163629.2; NP_001157101.1. [Q5TGP6-2]
DR UCSC; uc001ghg.4; human. [Q5TGP6-1]
DR CTD; 80133; -.
DR GeneCards; MROH9; -.
DR HGNC; HGNC:26287; MROH9.
DR HPA; ENSG00000117501; Tissue enhanced (brain, fallopian tube, testis).
DR neXtProt; NX_Q5TGP6; -.
DR OpenTargets; ENSG00000117501; -.
DR PharmGKB; PA142672447; -.
DR VEuPathDB; HostDB:ENSG00000117501; -.
DR eggNOG; KOG2032; Eukaryota.
DR GeneTree; ENSGT00940000162280; -.
DR HOGENOM; CLU_362444_0_0_1; -.
DR InParanoid; Q5TGP6; -.
DR OMA; QYTWMLN; -.
DR OrthoDB; 342683at2759; -.
DR PhylomeDB; Q5TGP6; -.
DR TreeFam; TF337192; -.
DR PathwayCommons; Q5TGP6; -.
DR BioGRID-ORCS; 80133; 14 hits in 1064 CRISPR screens.
DR GenomeRNAi; 80133; -.
DR Pharos; Q5TGP6; Tdark.
DR PRO; PR:Q5TGP6; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5TGP6; protein.
DR Bgee; ENSG00000117501; Expressed in olfactory segment of nasal mucosa and 34 other tissues.
DR ExpressionAtlas; Q5TGP6; baseline and differential.
DR Genevisible; Q5TGP6; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045206; Maestro_heat-like_prot.
DR PANTHER; PTHR23120; PTHR23120; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Repeat.
FT CHAIN 1..573
FT /note="Maestro heat-like repeat-containing protein family
FT member 9"
FT /id="PRO_0000285028"
FT REPEAT 118..155
FT /note="HEAT 1"
FT REPEAT 252..289
FT /note="HEAT 2"
FT REPEAT 292..328
FT /note="HEAT 3"
FT REPEAT 357..394
FT /note="HEAT 4"
FT REPEAT 418..458
FT /note="HEAT 5"
FT VAR_SEQ 533..573
FT /note="VSFVDCEQLCSHFLFLPKFKSKFQFLVSLPLNVGSYQDLRS -> LLNNFFK
FT DPLPEEFLVLFINWINDSNPVVSRLILHRIVHMSPIINKTENVSSILIAILDAFLSKDD
FT NVVLQALLTLRRLLNELDKVTYSLGTRIGSSYCTLMDHINGGIRSMAIRHFGQLVRDMR
FT QYTWMVNDVVLEGLVPLILFLEDDDKRVAEACKYTLKICTSQLKWSTSRLLKDENYSFE
FT MVVLNICNNLIISHRNYITDLTSDTLRFLWSPRTYLKRASVILIGYLAKSGGHLLLRDE
FT IEVMLDVIERLLRDEDPMIKQLAEITYDIFKKKAHKLTSAPLKQNFQKLLKLFYIKKLK
FT PLYNYNSPNGQIDSPTDSKDVKNDKAL (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_047654"
FT VARIANT 29
FT /note="N -> S (in dbSNP:rs17563089)"
FT /id="VAR_031903"
FT VARIANT 74
FT /note="V -> A (in dbSNP:rs2294740)"
FT /id="VAR_031904"
FT VARIANT 160
FT /note="Y -> H (in dbSNP:rs16863872)"
FT /id="VAR_031905"
FT CONFLICT 161
FT /note="I -> L (in Ref. 1; BAB15690)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 573 AA; 65050 MW; 21130BEB51C8F798 CRC64;
MLTRNPKTKS SLQILQDSVK WHHMAHKVNS LLDAYSGLLS NESMILAVNS SFVDPLLQFE
SQLKIIESSF GMLVVMPSLD KVKEMGSSYE YIEDMENLYH NILNIYENIL TSLVSKDLYK
LQILKEMLVW MSKDSSYLQE RIMVIINKVL RFTVTKVRKY ISVDAPCLGL LAAELSLLCS
HEDPSIVKQA SLGMCHLLYI ARCQNDIGTN KPTNGKSHSL QFPSSDVEFL PKEFQQDESK
IAQRVGQTLL PPLLTDFVQS LLMKLSSPDD KIASDAASIL IFTLEFHAEK VTMVSKIVDA
IYRQLCDNNC MKDVMLQVIT LLTCTSPKKV IFQLMDYPVP ADDTLIQMWK AACSQASVAP
HVLKTILLIL KGKPGEMEDT VTEGKRFSLD ITNLMPLAAC QALCTFLPLG SYRKAVAQYF
PQLLTTLMFQ VFYNSELKPI LKDRALYAQD ALRVLLNCSG LQQVDITLMK ENFWDQLSED
LCYYHGVCFI AKTLSEYNFP QFPETLSYLY KLSVEGPRRS EDTVIVLIFL TEVSFVDCEQ
LCSHFLFLPK FKSKFQFLVS LPLNVGSYQD LRS
