MRP2B_DANRE
ID MRP2B_DANRE Reviewed; 199 AA.
AC P0DM64;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2013, sequence version 1.
DT 03-AUG-2022, entry version 37.
DE RecName: Full=Melanocortin-2 receptor accessory protein 2B;
DE Short=zMRAP2b;
GN Name=mrap2b;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP FUNCTION, INTERACTION WITH MC4R, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=23869017; DOI=10.1126/science.1232995;
RA Sebag J.A., Zhang C., Hinkle P.M., Bradshaw A.M., Cone R.D.;
RT "Developmental control of the melanocortin-4 receptor by MRAP2 proteins in
RT zebrafish.";
RL Science 341:278-281(2013).
CC -!- FUNCTION: Activator of melanocortin receptor 4 (mc4r), a receptor
CC involved in energy homeostasis. Plays a role after larval development
CC in the control of energy homeostasis and body weight regulation by
CC increasing ligand-sensitivity of mc4r and mc4r-mediated generation of
CC cAMP once the zebrafish begins feeding, increasing the capacity for
CC regulated feeding and growth. {ECO:0000269|PubMed:23869017}.
CC -!- SUBUNIT: Interacts with mc4r. {ECO:0000269|PubMed:23869017}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane
CC protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in adult brain.
CC {ECO:0000269|PubMed:23869017}.
CC -!- DEVELOPMENTAL STAGE: Not expressed in embryos. Mainly expressed in
CC adult. {ECO:0000269|PubMed:23869017}.
CC -!- MISCELLANEOUS: Two paralogs of MRAP2 are present in zebrafish: mrap2a,
CC which plays a role during larval development and mrap2b, which
CC constitutes the ortholog of mammalian MRAP2.
CC {ECO:0000305|PubMed:23869017}.
CC -!- SIMILARITY: Belongs to the MRAP family. {ECO:0000305}.
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DR EMBL; BX649468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005168578.1; XM_005168521.3.
DR AlphaFoldDB; P0DM64; -.
DR SMR; P0DM64; -.
DR Ensembl; ENSDART00000168266; ENSDARP00000132698; ENSDARG00000103050.
DR GeneID; 101884805; -.
DR KEGG; dre:101884805; -.
DR CTD; 101884805; -.
DR ZFIN; ZDB-GENE-100729-5; mrap2b.
DR GeneTree; ENSGT00940000167806; -.
DR HOGENOM; CLU_110753_0_0_1; -.
DR OMA; ADYEWHY; -.
DR OrthoDB; 1318662at2759; -.
DR PRO; PR:P0DM64; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 4.
DR Bgee; ENSDARG00000103050; Expressed in dorsal periventricular hypothalamus and 3 other tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:ZFIN.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:ZFIN.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IDA:ZFIN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:ZFIN.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0031780; F:corticotropin hormone receptor binding; IBA:GO_Central.
DR GO; GO:0030545; F:signaling receptor regulator activity; IMP:UniProtKB.
DR GO; GO:0070996; F:type 1 melanocortin receptor binding; IBA:GO_Central.
DR GO; GO:0031781; F:type 3 melanocortin receptor binding; IBA:GO_Central.
DR GO; GO:0031782; F:type 4 melanocortin receptor binding; IDA:UniProtKB.
DR GO; GO:0031783; F:type 5 melanocortin receptor binding; IBA:GO_Central.
DR GO; GO:0051641; P:cellular localization; IDA:ZFIN.
DR GO; GO:0097009; P:energy homeostasis; IMP:UniProtKB.
DR GO; GO:0006112; P:energy reserve metabolic process; IMP:UniProtKB.
DR GO; GO:0106071; P:positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; IMP:ZFIN.
DR GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR GO; GO:0106070; P:regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0042594; P:response to starvation; IDA:ZFIN.
DR InterPro; IPR028111; MRAP.
DR PANTHER; PTHR28675; PTHR28675; 1.
DR Pfam; PF15183; MRAP; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Endoplasmic reticulum; Glycoprotein; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..199
FT /note="Melanocortin-2 receptor accessory protein 2B"
FT /id="PRO_0000424029"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 199 AA; 22563 MW; FAD2DC144C4D29AB CRC64;
MSEYSNRSQA GADYEWHYEY YEDEEPVSFE GLRANRYSIV IGFWVGLAVF VIFMFFVLTL
LTKTGAPHPE MCDASMKPHV LIGCELEVGG SLAFSLPPLP DQSRSLFHFY IHKEERVKTH
KDAVIGRGMH CGRGNAERAD EDEHFMSSFN IPNFVNSEQS SSLGHDDFLL SEPPIITDGQ
SDELKTAEPA HLCYDIIRH
