ID   MRP_LOTGI               Reviewed;         270 AA.
AC   B3A0R7;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=Methionine-rich protein;
DE   AltName: Full=Uncharacterized shell protein 19;
DE            Short=LUSP-19;
DE   Flags: Precursor;
OS   Lottia gigantea (Giant owl limpet).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX   NCBI_TaxID=225164;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND IDENTIFICATION.
RC   TISSUE=Mantle {ECO:0000269|Ref.1};
RA   Richardson P., Lucas S., Rokhsar D., Wang M., Lindquist E.A.;
RT   "DOE Joint Genome Institute Lottia gigantea EST project.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE OF 184-201 AND 230-246, SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RC   TISSUE=Shell;
RX   PubMed=23145877; DOI=10.1111/febs.12062;
RA   Marie B., Jackson D.J., Ramos-Silva P., Zanella-Cleon I., Guichard N.,
RA   Marin F.;
RT   "The shell-forming proteome of Lottia gigantea reveals both deep
RT   conservations and lineage-specific novelties.";
RL   FEBS J. 280:214-232(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23145877}.
CC   -!- TISSUE SPECIFICITY: Component of the acid-soluble organic matrix of
CC       calcified layers of the shell (at protein level).
CC       {ECO:0000269|PubMed:23145877}.
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DR   EMBL; FC620142; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; FC624777; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; B3A0R7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..270
FT                   /note="Methionine-rich protein"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000415251"
FT   REGION          31..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..71
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   270 AA;  29059 MW;  B274AB97A64BDAC9 CRC64;
     MLSLWAIGLL GLLNQVEALW SPSSYQSPAQ QRSAQFSSSG WGTSPAAQNP WSFNRPMPNT
     NMPNMNTGSL PGSMPGAMPG SMPGAMPGSM PGAMPGSMPG SMPGSMPNAM PGAMPGGTGS
     GFMAGAMPGA MPNMRSSNNM MGNMRNGYPP SYMTPSPRNT ICVAPVSQPR LCMVNGENTH
     KYRLKDVIEF LGHPNIEKVP KCVPGVPRVN CADYYAAQYI WKRGYCYCKN FHSNLPSYQM
     GSTQIRCVLN NCGACSQEFY VDKQRVVKCE