ID   MRP_STRSU               Reviewed;        1256 AA.
AC   P32653;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Muramidase-released protein;
DE   AltName: Full=136 kDa surface protein;
DE   Flags: Precursor;
GN   Name=mrp;
OS   Streptococcus suis.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1307;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Serotype 2 / D282;
RX   PubMed=1587602; DOI=10.1128/iai.60.6.2361-2367.1992;
RA   Smith H.E., Vecht U., Gielkens A.L., Smits M.A.;
RT   "Cloning and nucleotide sequence of the gene encoding the 136-kilodalton
RT   surface protein (muramidase-released protein) of Streptococcus suis type
RT   2.";
RL   Infect. Immun. 60:2361-2367(1992).
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000255|PROSITE-
CC       ProRule:PRU00477}; Peptidoglycan-anchor {ECO:0000255|PROSITE-
CC       ProRule:PRU00477}.
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DR   EMBL; X64450; CAA45781.1; -; Genomic_DNA.
DR   PIR; A43829; A43829.
DR   RefSeq; WP_012775059.1; NZ_WODB01000001.1.
DR   AlphaFoldDB; P32653; -.
DR   SMR; P32653; -.
DR   OMA; GGFFMRR; -.
DR   OrthoDB; 1159702at2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   InterPro; IPR019931; LPXTG_anchor.
DR   InterPro; IPR009459; MucBP_dom.
DR   InterPro; IPR027579; SSSPR51_Rpt.
DR   InterPro; IPR005877; YSIRK_signal_dom.
DR   Pfam; PF00746; Gram_pos_anchor; 1.
DR   Pfam; PF06458; MucBP; 4.
DR   Pfam; PF18877; SSSPR-51; 3.
DR   Pfam; PF04650; YSIRK_signal; 1.
DR   TIGRFAMs; TIGR04308; repeat_SSSPR51; 3.
DR   TIGRFAMs; TIGR01168; YSIRK_signal; 1.
DR   PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PE   3: Inferred from homology;
KW   Cell wall; Peptidoglycan-anchor; Repeat; Secreted; Signal.
FT   SIGNAL          1..47
FT                   /evidence="ECO:0000255"
FT   CHAIN           48..1226
FT                   /note="Muramidase-released protein"
FT                   /id="PRO_0000005629"
FT   PROPEP          1227..1256
FT                   /note="Removed by sortase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT                   /id="PRO_0000005630"
FT   REPEAT          663..681
FT                   /note="Small"
FT   REPEAT          839..861
FT                   /note="Small"
FT   REPEAT          953..1006
FT                   /note="Large"
FT   REPEAT          1064..1084
FT                   /note="Small"
FT   REPEAT          1089..1142
FT                   /note="Large"
FT   REPEAT          1143..1195
FT                   /note="Large"
FT   REGION          873..949
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          967..994
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1028..1049
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1102..1137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1196..1229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           1223..1227
FT                   /note="LPXTG sorting signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT   COMPBIAS        874..893
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        932..948
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1030..1049
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1226
FT                   /note="Pentaglycyl murein peptidoglycan amidated threonine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
SQ   SEQUENCE   1256 AA;  135796 MW;  DCF7F65242F14341 CRC64;
     MRRSNKKSFD WYGTKQQFSI RKYHFGAASV LLGVSLVLGA GAQVVKADET VASSEPTIAS
     SVAPASTEAV AEEAEKTNAE NTSAVATTST EVEKAKAVLE QVTSESPLLA GLGQKELAKT
     EDATLAKAIE DAQTKLAAAK AILADSEATV EQVEAQVAAV KVANEALGNE LQKYTVDGLL
     TAALDTVAPD TTASTLKVGD GEGTLLDSTT TATPSMAEPN GAAIAPHTLR TQDGIKATSE
     PNWYTFESYD LYSYNKNMAS STYKGAEVDA YIRYSLDNDS STTAVLAELV SRTTGDVLEK
     YTIEPGESVT FSHPTKVNAN NSNITVTYDT SLASANTPGA LKFSANDDVY STIIVPAYQI
     NTTRYVTESG KVLATYGLQT IAGQVVTPSS VRVFTGYDYV ATTTKAVQGP YPKGTVYLAG
     TVQKDTVQYK VIREIVENDQ AVLKFYYLDP TYKGEVDWRG TDTTGFIELL TTSPTTYKVG
     TIYDYNINSK ITAPFTIDPT KNVMVFKESE QNEQGSKYRV IAQWSGDETT KGIYGKIYIA
     TQVWTTKLGT NEWGWFDYSD DQAGIKFNNK GFWPAGVQNT LRNATPATAV ETTYIYKESS
     KYGDVIVEYY DTDGKQIVNS VVDTPKSALG TEYNTDVDRR PASLVAADGT VYFYKEVKSD
     SAKTTGTVVA GTTTVKYVYE KAGSVNVNFV DINGKVIKAP VSDEKDAKPG YNYDTDLDQK
     LASITFEGKE YKLVPAGDYP VGKVGKGNNL IEVGNNTAKG IDPTTGKIEA GVNKEVTYVY
     RAVTGSVVVN YKDTEGNVIK DPETDVSDAP VGDAYTTTDK KPNEIITKDG SRYVLVPSKT
     DGEENGKVIE GTITVTYVYQ KVANWIPEIP NVPETDRPKV PYPFDPTEPD EPIDPTTPGT
     NGEVPNIPYV PGYTPVDPKD NTPLKPIDPN DPGKGYVPPT PENPGVDTPI PYVPVKKVVT
     NHVDEEGNPI APQEEGTKPN KSIPGYEFTG KTVTDEDGNT THIYKKTPEV KNGTVVVNYV
     TEDGTVIKEP VTDTPTSPEG TPYDTTDNKP KTITFKGEEY ELVRVDGTEN GKVVEGETVV
     TYVYRKVETP AKKVVTNHVD EEGNPVAPQE EGTKPNKSIP GYEFTGKTVT DEDGNTTHIY
     KKTPAKKVVT NHVDEEGNPI APQEDGTTPK RQISGYEYVR TVVDEEGNTT HIYRKLSNKP
     TTPEKETPAK PQAGKTASGK AQLPNTGEAS SVAGALGTAM LVATLAFARK RRRNED