ID   MRR1_MONRU              Reviewed;         499 AA.
AC   A0A161CLJ6;
DT   07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT   06-JUL-2016, sequence version 1.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=Citrinin biosynthesis cluster MFS transporter mrr1 {ECO:0000303|Ref.1};
GN   Name=mrr1 {ECO:0000303|Ref.1};
OS   Monascus ruber (Mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Monascus.
OX   NCBI_TaxID=89489;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M7;
RX   DOI=10.1039/C5SC04027B;
RA   He Y., Cox R.J.;
RT   "The molecular steps of citrinin biosynthesis in fungi.";
RL   Chem. Sci. 7:2119-2127(2016).
CC   -!- FUNCTION: MFS transporter; part of the gene cluster that mediates the
CC       biosynthesis the mycotoxin citrinin, a hepato-nephrotoxic compound to
CC       humans due to inhibition of respiration complex III (Ref.1).
CC       {ECO:0000305|Ref.1}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. CAR1 family.
CC       {ECO:0000255}.
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DR   EMBL; KT781075; ALI92656.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A161CLJ6; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..499
FT                   /note="Citrinin biosynthesis cluster MFS transporter mrr1"
FT                   /id="PRO_0000440327"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        327..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        370..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        395..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        443..463
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        467..487
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        361
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   499 AA;  55181 MW;  C07A934908635631 CRC64;
     MKEEIDAPVS TDASGTDLEN ARDQPSGEKP TAVDIYLVEW DGPNDPELPM NFPLWKKSLI
     TCIFSTLTIW VTFSSSVFSA AAGITSKEFH VSVEVMTLGT SLTVLGFTVG PLVWGPMSEL
     YGRLKPLYIG YAIFIIFQVP VAVAQNLETL MLARFFLGFF GTSALAIIPG ALADFWGPVE
     RAIAISLFSA ATFVGPIFGP IIGGFIVDSS LGWRWTAWIT MIPASFFGII AFLTLPETYH
     PVLLQRRASR LRKETRIWAY HSRLDENTPT FGEILTKYLF RPIQMLFLEP ILVCMTIYIS
     LIYGILYLFF VAYPIAFREV RNWKSLGIAA LPFLGILVGV LMGCLLVTIA TRLWYAPKLQ
     NGSVVPEDRL PPMIVAAILL PIGLFWFGWT SSPSISWAPQ AIAGAPIGMG ILMIWMQGLN
     YLIDVYLVVA NSAMSANTLI RSAVGAAFPL FATAMYHKLG VDWATSLLGF LSIAMIPIPV
     IFYFYGAKIR ALSRFSPKW