MRS23_ARATH
ID MRS23_ARATH Reviewed; 484 AA.
AC Q9LJN2;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Magnesium transporter MRS2-3;
DE AltName: Full=Magnesium Transporter 4;
DE Short=AtMGT4;
GN Name=MRS2-3; Synonyms=MGT4; OrderedLocusNames=At3g19640; ORFNames=MMB12.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=11752386; DOI=10.2307/3871533;
RA Li L., Tutone A.F., Drummond R.S., Gardner R.C., Luan S.;
RT "A novel family of magnesium transport genes in Arabidopsis.";
RL Plant Cell 13:2761-2775(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY, NOMENCLATURE, AND TISSUE SPECIFICITY.
RX PubMed=19966073; DOI=10.1105/tpc.109.070557;
RA Gebert M., Meschenmoser K., Svidova S., Weghuber J., Schweyen R.,
RA Eifler K., Lenz H., Weyand K., Knoop V.;
RT "A root-expressed magnesium transporter of the MRS2/MGT gene family in
RT Arabidopsis thaliana allows for growth in low-Mg2+ environments.";
RL Plant Cell 21:4018-4030(2009).
CC -!- FUNCTION: Magnesium transporter that may mediate the influx of
CC magnesium. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in the whole plant.
CC {ECO:0000269|PubMed:11752386, ECO:0000269|PubMed:19966073}.
CC -!- MISCELLANEOUS: Has the ability to complement a mutant in yeast lacking
CC magnesium transport capability.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC
CC 1.A.35.5) family. {ECO:0000305}.
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DR EMBL; AY150288; AAN73213.1; -; mRNA.
DR EMBL; AP000417; BAB02549.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76270.1; -; Genomic_DNA.
DR EMBL; BT000458; AAN17435.1; -; mRNA.
DR EMBL; BT006622; AAP31966.1; -; mRNA.
DR PIR; T52392; T52392.
DR RefSeq; NP_188598.2; NM_112854.4.
DR AlphaFoldDB; Q9LJN2; -.
DR SMR; Q9LJN2; -.
DR BioGRID; 6834; 2.
DR IntAct; Q9LJN2; 1.
DR STRING; 3702.AT3G19640.1; -.
DR PaxDb; Q9LJN2; -.
DR PRIDE; Q9LJN2; -.
DR ProteomicsDB; 238910; -.
DR EnsemblPlants; AT3G19640.1; AT3G19640.1; AT3G19640.
DR GeneID; 821501; -.
DR Gramene; AT3G19640.1; AT3G19640.1; AT3G19640.
DR KEGG; ath:AT3G19640; -.
DR Araport; AT3G19640; -.
DR TAIR; locus:2091176; AT3G19640.
DR eggNOG; KOG2662; Eukaryota.
DR HOGENOM; CLU_034694_0_0_1; -.
DR InParanoid; Q9LJN2; -.
DR OMA; WTNLYDL; -.
DR OrthoDB; 1363588at2759; -.
DR PhylomeDB; Q9LJN2; -.
DR PRO; PR:Q9LJN2; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LJN2; baseline and differential.
DR Genevisible; Q9LJN2; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IDA:TAIR.
DR GO; GO:0015693; P:magnesium ion transport; IBA:GO_Central.
DR CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR InterPro; IPR039204; MRS2-like.
DR PANTHER; PTHR13890; PTHR13890; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Ion transport; Magnesium; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..484
FT /note="Magnesium transporter MRS2-3"
FT /id="PRO_0000394167"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 455..475
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 203..275
FT /evidence="ECO:0000255"
FT MOTIF 437..439
FT /note="Required for magnesium transport activity"
FT COMPBIAS 9..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 484 AA; 53458 MW; 66B8D92213F24149 CRC64;
MRGARPDEFN FSTNPSTPNT GQPTPTYPAG VGGGGGGRKK GVGVRTWLVL NSSGQSEPKE
EGKHSIMRRT GLPARDLRIL DPLLSYPSTV LGRERAIVIN LEHIKAIITA QEVLLLNSKD
PSVSPFIDEL QRRILCHHHA TKPQEEQNSG GEPHTRVDPA QGEAGTEQSS GDQGSEAKKD
AKQSLENQDG SKVLPFEFVA LEACLEAASS SLEHEALRLE LEAHPALDKL TSKISTLNLE
RVRQIKSRLV AITGRVQKVR DELEHLLDDD EDMAEMYLTE KLAQKLEDSS NSSMNESDTF
EVDLPQGDED DRLPPEFASE ANRDGRYLQA NDAHELLMST QSALSRNSRG THTSSTRSAM
TNKLDVEELE MLLEAYFVQI DGILNKLSTL REYVDDTEDY INIMLDDKQN HLLQMGVMLT
TATLVMSAFI AVAGVFGMNI TIELFTDNKH GPSRFIWTVI GGSIGSICLY VGAIGWCKYK
RLLE
