MRS24_ARATH
ID MRS24_ARATH Reviewed; 436 AA.
AC Q93ZD7; Q9LYT9;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Magnesium transporter MRS2-4;
DE AltName: Full=Magnesium Transporter 6;
DE Short=AtMGT6;
GN Name=MRS2-4; Synonyms=MGT6; OrderedLocusNames=At3g58970;
GN ORFNames=F17J16.20;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=11752386; DOI=10.2307/3871533;
RA Li L., Tutone A.F., Drummond R.S., Gardner R.C., Luan S.;
RT "A novel family of magnesium transport genes in Arabidopsis.";
RL Plant Cell 13:2761-2775(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY, NOMENCLATURE, AND TISSUE SPECIFICITY.
RX PubMed=19966073; DOI=10.1105/tpc.109.070557;
RA Gebert M., Meschenmoser K., Svidova S., Weghuber J., Schweyen R.,
RA Eifler K., Lenz H., Weyand K., Knoop V.;
RT "A root-expressed magnesium transporter of the MRS2/MGT gene family in
RT Arabidopsis thaliana allows for growth in low-Mg2+ environments.";
RL Plant Cell 21:4018-4030(2009).
CC -!- FUNCTION: Magnesium transporter that may mediate the influx of
CC magnesium. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in the whole plant except roots.
CC {ECO:0000269|PubMed:11752386, ECO:0000269|PubMed:19966073}.
CC -!- MISCELLANEOUS: Has the ability to complement a mutant in yeast lacking
CC magnesium transport capability.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC
CC 1.A.35.5) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB86925.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY150289; AAN73214.1; -; mRNA.
DR EMBL; AL163527; CAB86925.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE79855.1; -; Genomic_DNA.
DR EMBL; AY057613; AAL14408.1; -; mRNA.
DR EMBL; BT002266; AAN72277.1; -; mRNA.
DR PIR; T47779; T47779.
DR RefSeq; NP_567076.1; NM_115759.4.
DR AlphaFoldDB; Q93ZD7; -.
DR SMR; Q93ZD7; -.
DR BioGRID; 10381; 6.
DR IntAct; Q93ZD7; 6.
DR STRING; 3702.AT3G58970.1; -.
DR TCDB; 1.A.35.5.4; the cora metal ion transporter (mit) family.
DR PaxDb; Q93ZD7; -.
DR PRIDE; Q93ZD7; -.
DR ProteomicsDB; 238911; -.
DR EnsemblPlants; AT3G58970.1; AT3G58970.1; AT3G58970.
DR GeneID; 825066; -.
DR Gramene; AT3G58970.1; AT3G58970.1; AT3G58970.
DR KEGG; ath:AT3G58970; -.
DR Araport; AT3G58970; -.
DR TAIR; locus:2077665; AT3G58970.
DR eggNOG; KOG2662; Eukaryota.
DR HOGENOM; CLU_034694_1_0_1; -.
DR InParanoid; Q93ZD7; -.
DR OMA; TRNNCII; -.
DR OrthoDB; 1363588at2759; -.
DR PhylomeDB; Q93ZD7; -.
DR BRENDA; 7.2.2.14; 399.
DR PRO; PR:Q93ZD7; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q93ZD7; baseline and differential.
DR Genevisible; Q93ZD7; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IDA:TAIR.
DR GO; GO:0015693; P:magnesium ion transport; IBA:GO_Central.
DR CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR InterPro; IPR045863; CorA_TM1_TM2.
DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR InterPro; IPR039204; MRS2-like.
DR PANTHER; PTHR13890; PTHR13890; 1.
DR Pfam; PF01544; CorA; 1.
DR SUPFAM; SSF144083; SSF144083; 1.
PE 2: Evidence at transcript level;
KW Ion transport; Magnesium; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..436
FT /note="Magnesium transporter MRS2-4"
FT /id="PRO_0000394168"
FT TRANSMEM 372..392
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 392..394
FT /note="Required for magnesium transport activity"
SQ SEQUENCE 436 AA; 48404 MW; A9EF73B60CA539AF CRC64;
MGKGPLSFRR LSSIRHRKKG SAVKDDSAQT STPSSPPPPL PIHAGGSAVG ATGKAKKKTG
GARLWMRFDR TGAMEVVECD KSTIIKRASV PARDLRILGP VFSHSSNILA REKAIVVNLE
VIKAIVTAEE VLLLDPLRPE VLPFVERLKQ QFPQRNGNEN ALQASANVQS PLDPEAAEGL
QSELPFEFQV LEIALEVVCS FVDKSVAALE TEAWPVLDEL TKNVSTENLE YVRSLKSNLT
RLLARVQKVR DELEHLLDDN EDMADLYLTR KWIQNQQTEA ILAGTASNSI ALPAHNTSNL
HRLTSNRSAS MVTSNTEEDD VEDLEMLLEA YFMQLDGMRN KILTVREYID DTEDYVNIQL
DNQRNELIQL QLTLTIASFA IAAETLLASL FGMNIPCPLY SIHGVFGYFV WSVTALCIVL
FMVTLGYARW KKLLGS
