ID   MRS28_ARATH             Reviewed;         380 AA.
AC   P0CZ21; Q682I2; Q8H1G7; Q9FXX0; Q9LXD5;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=Magnesium transporter MRS2-8;
DE   AltName: Full=Magnesium Transporter 8;
DE            Short=AtMGT8;
GN   Name=MRS2-8; Synonyms=MGT8;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND TISSUE SPECIFICITY.
RC   STRAIN=cv. Landsberg erecta;
RX   PubMed=11752386; DOI=10.2307/3871533;
RA   Li L., Tutone A.F., Drummond R.S., Gardner R.C., Luan S.;
RT   "A novel family of magnesium transport genes in Arabidopsis.";
RL   Plant Cell 13:2761-2775(2001).
RN   [2]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=19966073; DOI=10.1105/tpc.109.070557;
RA   Gebert M., Meschenmoser K., Svidova S., Weghuber J., Schweyen R.,
RA   Eifler K., Lenz H., Weyand K., Knoop V.;
RT   "A root-expressed magnesium transporter of the MRS2/MGT gene family in
RT   Arabidopsis thaliana allows for growth in low-Mg2+ environments.";
RL   Plant Cell 21:4018-4030(2009).
CC   -!- FUNCTION: Magnesium transporter that may mediate the influx of
CC       magnesium. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in the whole plant except stems.
CC       {ECO:0000269|PubMed:11752386}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC
CC       1.A.35.5) family. {ECO:0000305}.
CC   -!- CAUTION: Has been shown to be a pseudogene in cv. Columbia (AC P0CZ22)
CC       due to a naturally occurring frameshift at position 277 in this strain.
CC       The sequence shown is from strain cv. Landsberg erecta. {ECO:0000305}.
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DR   EMBL; AY150293; AAN73218.1; -; mRNA.
DR   PIR; T49926; T49926.
DR   AlphaFoldDB; P0CZ21; -.
DR   SMR; P0CZ21; -.
DR   PhylomeDB; P0CZ21; -.
DR   ExpressionAtlas; P0CZ21; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:UniProt.
DR   CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR   InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR   InterPro; IPR039204; MRS2-like.
DR   PANTHER; PTHR13890; PTHR13890; 1.
DR   Pfam; PF01544; CorA; 1.
PE   2: Evidence at transcript level;
KW   Ion transport; Magnesium; Membrane; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..380
FT                   /note="Magnesium transporter MRS2-8"
FT                   /id="PRO_0000394172"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        352..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           336..338
FT                   /note="Required for magnesium transport activity"
SQ   SEQUENCE   380 AA;  42913 MW;  51E0E0EEF85840F8 CRC64;
     MLPNEELVPV KRITPQSSWS WISIDATGKK TVLDVDKYVI MHRVQIHARD LRILDPNLFY
     PSAILGRERA IVLNLEHIKA IITAKEVLIQ DSSDENLIPT LEEFQTRLSV GNKAHGGQLD
     GDVVEEDESA FEFRALEVAL EAICSFLAAR TIELEKSAYP ALDELTLKLT SRNLLRVCKL
     KSSMTRLTAQ VQKIKDELEQ LLEDDEDMAE LYLSRKLAGA SSPAIDSGEH INWYPTSPTI
     GAKISRAKSH LVRSATVRGD DKNDVEEVEM LLEAHFMQID RTLNKLTELR EYVDETEDFL
     NIQLDSSRNQ LIKFEIILTA GSICVSVYSV VVGILGMNIP FPWNIKKHMF KWVVSGTATV
     CAILFVTIMS FARYKKLFGF