ID   MRS2B_ORYSJ             Reviewed;         436 AA.
AC   Q67UQ7; A0A0P0WZR6;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Magnesium transporter MRS2-B;
GN   Name=MRS2-B; OrderedLocusNames=Os06g0650800, LOC_Os06g44150;
GN   ORFNames=P0453H04.31;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [5]
RP   GENE FAMILY.
RX   PubMed=19966073; DOI=10.1105/tpc.109.070557;
RA   Gebert M., Meschenmoser K., Svidova S., Weghuber J., Schweyen R.,
RA   Eifler K., Lenz H., Weyand K., Knoop V.;
RT   "A root-expressed magnesium transporter of the MRS2/MGT gene family in
RT   Arabidopsis thaliana allows for growth in low-Mg2+ environments.";
RL   Plant Cell 21:4018-4030(2009).
CC   -!- FUNCTION: Magnesium transporter that may mediate the influx of
CC       magnesium. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC
CC       1.A.35.5) family. {ECO:0000305}.
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DR   EMBL; AP005453; BAD38112.1; -; Genomic_DNA.
DR   EMBL; AP008212; BAF20137.1; -; Genomic_DNA.
DR   EMBL; AP014962; BAS98900.1; -; Genomic_DNA.
DR   EMBL; AK071905; BAG92749.1; -; mRNA.
DR   EMBL; AK099209; BAG93997.1; -; mRNA.
DR   RefSeq; XP_015643498.1; XM_015788012.1.
DR   AlphaFoldDB; Q67UQ7; -.
DR   SMR; Q67UQ7; -.
DR   STRING; 4530.OS06T0650800-01; -.
DR   PaxDb; Q67UQ7; -.
DR   PRIDE; Q67UQ7; -.
DR   EnsemblPlants; Os06t0650800-01; Os06t0650800-01; Os06g0650800.
DR   EnsemblPlants; Os06t0650800-02; Os06t0650800-02; Os06g0650800.
DR   GeneID; 4341687; -.
DR   Gramene; Os06t0650800-01; Os06t0650800-01; Os06g0650800.
DR   Gramene; Os06t0650800-02; Os06t0650800-02; Os06g0650800.
DR   KEGG; osa:4341687; -.
DR   eggNOG; KOG2662; Eukaryota.
DR   HOGENOM; CLU_034694_1_1_1; -.
DR   InParanoid; Q67UQ7; -.
DR   OMA; RNFDNVF; -.
DR   OrthoDB; 1363588at2759; -.
DR   Proteomes; UP000000763; Chromosome 6.
DR   Proteomes; UP000059680; Chromosome 6.
DR   Genevisible; Q67UQ7; OS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015693; P:magnesium ion transport; IBA:GO_Central.
DR   CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR   InterPro; IPR045863; CorA_TM1_TM2.
DR   InterPro; IPR039204; MRS2-like.
DR   PANTHER; PTHR13890; PTHR13890; 1.
DR   SUPFAM; SSF144083; SSF144083; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Ion transport; Magnesium; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..436
FT                   /note="Magnesium transporter MRS2-B"
FT                   /id="PRO_0000394267"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        408..428
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          176..242
FT                   /evidence="ECO:0000255"
FT   MOTIF           392..394
FT                   /note="Required for magnesium transport activity"
SQ   SEQUENCE   436 AA;  48473 MW;  EFC5CC2EC0EAD785 CRC64;
     MSAAAASSAA GDSAKQPLLH HQRGNPPHVA SVSSPSLPSA PPGALAGGRR FPGGLDVPNL
     KKRGGGTRSW IRVEAATASV QTLEVDKATM MRRCELPARD LRLLDPLFVY PSTILGRERA
     IVVNLEQIRC VITADEVLLL NSLDSYVLQY AAELQRRLLQ RAEGDELPFE FRALELALEA
     ACSFLDAQAA ELEIEAYPLL DELTSKISTL NLERVRRLKS RLVALTRRVQ KVRDEIEQLM
     DDDGDMAEMY LSEKKLRTEA SFYGDQSMLG YNSVGDGTSF SAPVSPVSSP TESRKLEKAF
     SLCRSRHDSV KSSDNTATEH IQELEMLLEA YFVVIDSTLN KLTSLKEYID DTEDFINIQL
     DNVRNQLIQF ELLLTTATFV VAIFGVVAGI FGMNFETSVF SIQNAFQWVL IITGVIGAFI
     FCGFLWFFKY KRLMPL