ID   MRS2D_ORYSJ             Reviewed;         434 AA.
AC   Q7XQQ1; B9FF88;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Putative magnesium transporter MRS2-D;
GN   Name=MRS2-D; OrderedLocusNames=Os04g0430900, LOC_Os04g35160;
GN   ORFNames=OsJ_14848, OSJNBa0084A10.4;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12447439; DOI=10.1038/nature01183;
RA   Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J., Liu Y.,
RA   Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y., Weng Q.,
RA   Zhang L., Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D., Liu X., Lu T.,
RA   Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J., Wu M., Zhang R.,
RA   Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H., Cai Z., Ren S., Lv G.,
RA   Gu W., Zhu G., Tu Y., Jia J., Zhang Y., Chen J., Kang H., Chen X., Shao C.,
RA   Sun Y., Hu Q., Zhang X., Zhang W., Wang L., Ding C., Sheng H., Gu J.,
RA   Chen S., Ni L., Zhu F., Chen W., Lan L., Lai Y., Cheng Z., Gu M., Jiang J.,
RA   Li J., Hong G., Xue Y., Han B.;
RT   "Sequence and analysis of rice chromosome 4.";
RL   Nature 420:316-320(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [6]
RP   GENE FAMILY.
RX   PubMed=19966073; DOI=10.1105/tpc.109.070557;
RA   Gebert M., Meschenmoser K., Svidova S., Weghuber J., Schweyen R.,
RA   Eifler K., Lenz H., Weyand K., Knoop V.;
RT   "A root-expressed magnesium transporter of the MRS2/MGT gene family in
RT   Arabidopsis thaliana allows for growth in low-Mg2+ environments.";
RL   Plant Cell 21:4018-4030(2009).
CC   -!- FUNCTION: Putative magnesium transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC
CC       1.A.35.5) family. {ECO:0000305}.
CC   -!- CAUTION: Lacks the GMN motif, which is a conserved feature of the
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EEE61022.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AL606458; CAE03029.1; -; Genomic_DNA.
DR   EMBL; AP008210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP014960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CM000141; EEE61022.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; Q7XQQ1; -.
DR   SMR; Q7XQQ1; -.
DR   STRING; 4530.OS04T0430900-00; -.
DR   PaxDb; Q7XQQ1; -.
DR   eggNOG; KOG2662; Eukaryota.
DR   HOGENOM; CLU_034694_0_0_1; -.
DR   InParanoid; Q7XQQ1; -.
DR   OrthoDB; 1363588at2759; -.
DR   Proteomes; UP000000763; Chromosome 4.
DR   Proteomes; UP000007752; Chromosome 4.
DR   Proteomes; UP000059680; Chromosome 4.
DR   Genevisible; Q7XQQ1; OS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015693; P:magnesium ion transport; IBA:GO_Central.
DR   CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR   InterPro; IPR039204; MRS2-like.
DR   PANTHER; PTHR13890; PTHR13890; 1.
PE   3: Inferred from homology;
KW   Ion transport; Magnesium; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..434
FT                   /note="Putative magnesium transporter MRS2-D"
FT                   /id="PRO_0000394271"
FT   TRANSMEM        367..387
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        405..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          126..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          279..311
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        279..296
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   434 AA;  45555 MW;  A6C18106EE091BCB CRC64;
     MAARRRHVAA GAGAPAPAAG EWAAVTAGGG AAWALSPVEE VGTKQELMRR TGLPPRDLRA
     LDPALSSAAS ASSCRPSAIT GRDRAVVVNL DRARAVITAS EVLVPSPRDP AVAPLVRELR
     ARLALAASPT PAPSPSPPQH GMAVGMDGSI SPSQASRGGE EAAGNGKDGE ALGGGDKALP
     FEFRALEVCL EFACKSLEHE TCTLEKEAYP ALDELTSKVS TLNLERVRQI KSRLVAISGK
     VQKVRDELEH LLDDDMDMAA LHLTEKLAYQ SSRFDIDKEA SELEDHSSRD EEGVEGGGGG
     DGDDETIAGG GSFSPNTDEL EILLESYFVQ IDGTLNSLST LREYVEDTED YINMMLDEKQ
     NQLLQMGILL STGTLVSSCA IAVTGVFGIN VHISLYDSPA SSAAFPCAAA GIVAGSLALY
     LAALLCYKRA GILQ