ID   MRS2E_ORYSI             Reviewed;         418 AA.
AC   A2WXD3;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Magnesium transporter MRS2-E;
GN   Name=MRS2-E; ORFNames=OsI_04582;
OS   Oryza sativa subsp. indica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39946;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. 93-11;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
CC   -!- FUNCTION: Magnesium transporter that may mediate the influx of
CC       magnesium. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC
CC       1.A.35.5) family. {ECO:0000305}.
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DR   EMBL; CM000126; EAY76629.1; -; Genomic_DNA.
DR   AlphaFoldDB; A2WXD3; -.
DR   SMR; A2WXD3; -.
DR   STRING; 39946.A2WXD3; -.
DR   EnsemblPlants; BGIOSGA004878-TA; BGIOSGA004878-PA; BGIOSGA004878.
DR   Gramene; BGIOSGA004878-TA; BGIOSGA004878-PA; BGIOSGA004878.
DR   HOGENOM; CLU_034694_0_0_1; -.
DR   OMA; IHIELMK; -.
DR   Proteomes; UP000007015; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:UniProt.
DR   CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR   InterPro; IPR039204; MRS2-like.
DR   PANTHER; PTHR13890; PTHR13890; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Ion transport; Magnesium; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..418
FT                   /note="Magnesium transporter MRS2-E"
FT                   /id="PRO_0000394274"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          119..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          258..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          166..232
FT                   /evidence="ECO:0000255"
FT   MOTIF           365..367
FT                   /note="Required for magnesium transport activity"
FT   COMPBIAS        128..142
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   418 AA;  46401 MW;  6C9BA34D558F1AD7 CRC64;
     MERRAQPVSA AVAPVTGRRK GAAASRKWMV VPAVGEERRV EFGKHQIMKM TGLPGRDLRV
     LDPVLSYPST ILGRDRAIVV RLQGVKAIIT ATEVLVPDHD DVLLASFLLD LRSRLSLPDA
     APSTNPAAAD RGNGTEQGDQ GSVPGLAISG AGNAKIPPFE FKVLEVCLEH ACKDLESQTR
     SLEKEAYPAL DKLGSKVSTL NLDHVRNLKS RMVDLSGRVQ KIRDELEHLL DDDMDMSEMY
     LTRKLSFQGL SGSLSRADSH KYASVDHDDD REEEDHDDET ESGRESSVYV KPDIEELEML
     LEAYFVQIDG TLNTLYHIRE YADDTEDYIN IMLDEKQNQL LQMGVMLTTA TVVVTAGIVV
     VSLFGMNIHI DLMKDPETPE MVRMSNMHFW ETTFGTVAGC IAIYLLAIYA GRKSKILQ