ID   MRS2I_ORYSJ             Reviewed;         384 AA.
AC   Q10D38; Q75KW8;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Magnesium transporter MRS2-I;
GN   Name=MRS2-I; OrderedLocusNames=Os03g0742400, LOC_Os03g53110;
GN   ORFNames=OJ1365_D05.9, OsJ_12521;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16109971; DOI=10.1101/gr.3869505;
RG   The rice chromosome 3 sequencing consortium;
RA   Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA   Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA   Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA   Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA   Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA   Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA   Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA   Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA   Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA   Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA   O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA   Jin W., Lee H.R., Jiang J., Jackson S.;
RT   "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT   and diverged grass species.";
RL   Genome Res. 15:1284-1291(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 136-384.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [6]
RP   GENE FAMILY.
RX   PubMed=19966073; DOI=10.1105/tpc.109.070557;
RA   Gebert M., Meschenmoser K., Svidova S., Weghuber J., Schweyen R.,
RA   Eifler K., Lenz H., Weyand K., Knoop V.;
RT   "A root-expressed magnesium transporter of the MRS2/MGT gene family in
RT   Arabidopsis thaliana allows for growth in low-Mg2+ environments.";
RL   Plant Cell 21:4018-4030(2009).
CC   -!- FUNCTION: Magnesium transporter that may mediate the influx of
CC       magnesium. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC
CC       1.A.35.5) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAR87307.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=AK060249; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AC096855; AAR87307.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; DP000009; ABF98804.1; -; Genomic_DNA.
DR   EMBL; AP014959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CM000140; EEE59906.1; -; Genomic_DNA.
DR   EMBL; AK060249; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; XP_015633129.1; XM_015777643.1.
DR   AlphaFoldDB; Q10D38; -.
DR   SMR; Q10D38; -.
DR   STRING; 4530.OS03T0742400-01; -.
DR   PaxDb; Q10D38; -.
DR   PRIDE; Q10D38; -.
DR   GeneID; 4334067; -.
DR   KEGG; osa:4334067; -.
DR   eggNOG; KOG2662; Eukaryota.
DR   InParanoid; Q10D38; -.
DR   OrthoDB; 1363588at2759; -.
DR   Proteomes; UP000000763; Chromosome 3.
DR   Proteomes; UP000007752; Chromosome 3.
DR   Proteomes; UP000059680; Chromosome 3.
DR   Genevisible; Q10D38; OS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015693; P:magnesium ion transport; IBA:GO_Central.
DR   CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR   InterPro; IPR045863; CorA_TM1_TM2.
DR   InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR   InterPro; IPR039204; MRS2-like.
DR   PANTHER; PTHR13890; PTHR13890; 1.
DR   Pfam; PF01544; CorA; 1.
DR   SUPFAM; SSF144083; SSF144083; 1.
PE   2: Evidence at transcript level;
KW   Ion transport; Magnesium; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..384
FT                   /note="Magnesium transporter MRS2-I"
FT                   /id="PRO_0000394281"
FT   TRANSMEM        319..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        356..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           339..341
FT                   /note="Required for magnesium transport activity"
SQ   SEQUENCE   384 AA;  42189 MW;  5DAD7E502339F96B CRC64;
     MAAAVVVAGE AAAAAAAAGA GGKKRGASRS WILFDAAGEE RVLDADKYAI MHRVDINARD
     LRILDPLLSY PSTILGRERA IVLNLEHIKA IITAEEVLLR DPLDDNVIPV VEELRRRLAP
     SSATQHDVEG AEEDESPFEF RALEVTLEAI CSFLGARTTE LESAAYPALD ELTSKISSRN
     LDRVRKLKSG MTRLNARVQK VRDELEQLLD DDDDMADLYL SRKLAGAASP VSGSGGPNWF
     PASPTIGSKI SRASRASAPT IHGNENDVEE LEMLLEAYFM QIDGTLNKLT TLREYIDDTE
     DYINIQLDNH RNQLIQLELF LSSGTVCLSL YSLVAGIFGM NIPYTWNDNH GYVFKWVVLV
     SGLFCAFMFV SIVAYARHKG LVGS