ID   MRS2_ASHGO              Reviewed;         423 AA.
AC   Q759B8;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Mitochondrial inner membrane magnesium transporter MRS2;
DE   AltName: Full=RNA-splicing protein MRS2;
DE   Flags: Precursor;
GN   Name=MRS2; OrderedLocusNames=ADR359W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: High-conductance magnesium-selective channel that mediates
CC       the influx of magnesium into the mitochondrial matrix. Essential for
CC       the splicing of mRNA group II introns in mitochondria by affecting
CC       mitochondrial magnesium concentrations, which are critical for group II
CC       intron splicing. It also suppresses a variety of mitochondrial intron
CC       mutations and its absence may disturb the assembly of mitochondrial
CC       membrane complexes. {ECO:0000250|UniProtKB:Q01926}.
CC   -!- SUBUNIT: Homopentamer. Forms homooligomers. Interacts with MFM1.
CC       {ECO:0000250|UniProtKB:Q01926}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q01926}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q01926}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC       family. {ECO:0000305}.
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DR   EMBL; AE016817; AAS52279.1; -; Genomic_DNA.
DR   RefSeq; NP_984455.1; NM_209808.1.
DR   AlphaFoldDB; Q759B8; -.
DR   SMR; Q759B8; -.
DR   STRING; 33169.AAS52279; -.
DR   PRIDE; Q759B8; -.
DR   EnsemblFungi; AAS52279; AAS52279; AGOS_ADR359W.
DR   GeneID; 4620620; -.
DR   KEGG; ago:AGOS_ADR359W; -.
DR   eggNOG; KOG2662; Eukaryota.
DR   HOGENOM; CLU_025144_1_0_1; -.
DR   InParanoid; Q759B8; -.
DR   OMA; TQHDVEG; -.
DR   Proteomes; UP000000591; Chromosome IV.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0015693; P:magnesium ion transport; IBA:GO_Central.
DR   GO; GO:0045016; P:mitochondrial magnesium ion transmembrane transport; ISS:UniProtKB.
DR   CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR   InterPro; IPR039204; MRS2-like.
DR   PANTHER; PTHR13890; PTHR13890; 1.
PE   3: Inferred from homology;
KW   Ion transport; Magnesium; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix; Transport.
FT   TRANSIT         1..25
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..423
FT                   /note="Mitochondrial inner membrane magnesium transporter
FT                   MRS2"
FT                   /id="PRO_0000043241"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        324..344
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           313..316
FT                   /note="CGMN"
SQ   SEQUENCE   423 AA;  47592 MW;  3E7823E873185472 CRC64;
     MLRWIPTRIC PRLCTRGFAS SCARLAQGPA FFVKPITPND LFVSCTVFNE KGAVTGVSER
     YPKLSFLRDR GLYPRDLRKL DTSSIEVIPS IVVKPTCILV NLLHIKAVIE KNRVYVFDTT
     SKEAAARLGV LMYDLESKLA SHSSQPAQHY EHRALESILV NVMTCLETEF KHLSKQCGLV
     LNELEDQIDR DKLRDLLIHS KDLTSFYQKS LLIRDMLDEL LESDEDLAAM CLSPAPGTVE
     ADAAEVEMLL ETYYKQCDEY VQQSGSLLQN IKSTEDVVNI ILDANRNSLM LFELKVTIYT
     LGFTVATLLP AFCGMNLKNF IEESVWGFGG VLAVSAVAGL AVTASNFKAL RNVARLTVMN
     SHSTSPGAKN ISSARLHLDR DVPTLWMRLK TAFRTIWFGK SRPSRDGRQR DMIWKWLLDD
     TSK