MRS2_ASPFU
ID MRS2_ASPFU Reviewed; 597 AA.
AC Q4WCV3;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Mitochondrial inner membrane magnesium transporter mrs2;
DE AltName: Full=RNA-splicing protein mrs2;
DE Flags: Precursor;
GN Name=mrs2; ORFNames=AFUA_6G02550;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: High-conductance magnesium-selective channel that mediates
CC the influx of magnesium into the mitochondrial matrix. Essential for
CC the splicing of mRNA group II introns in mitochondria by affecting
CC mitochondrial magnesium concentrations, which are critical for group II
CC intron splicing. It also suppresses a variety of mitochondrial intron
CC mutations and its absence may disturb the assembly of mitochondrial
CC membrane complexes. {ECO:0000250|UniProtKB:Q01926}.
CC -!- SUBUNIT: Homopentamer. Forms homooligomers. Interacts with MFM1.
CC {ECO:0000250|UniProtKB:Q01926}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q01926}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q01926}.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC family. {ECO:0000305}.
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DR EMBL; AAHF01000012; EAL85785.1; -; Genomic_DNA.
DR RefSeq; XP_747823.1; XM_742730.1.
DR AlphaFoldDB; Q4WCV3; -.
DR SMR; Q4WCV3; -.
DR STRING; 746128.CADAFUBP00009307; -.
DR EnsemblFungi; EAL85785; EAL85785; AFUA_6G02550.
DR GeneID; 3505100; -.
DR KEGG; afm:AFUA_6G02550; -.
DR VEuPathDB; FungiDB:Afu6g02550; -.
DR eggNOG; KOG2662; Eukaryota.
DR HOGENOM; CLU_025144_2_1_1; -.
DR InParanoid; Q4WCV3; -.
DR OMA; DDLTAMY; -.
DR OrthoDB; 1363588at2759; -.
DR Proteomes; UP000002530; Chromosome 6.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015693; P:magnesium ion transport; IBA:GO_Central.
DR GO; GO:0045016; P:mitochondrial magnesium ion transmembrane transport; ISS:UniProtKB.
DR CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR InterPro; IPR039204; MRS2-like.
DR PANTHER; PTHR13890; PTHR13890; 1.
DR Pfam; PF01544; CorA; 1.
PE 3: Inferred from homology;
KW Ion transport; Magnesium; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW Transmembrane; Transmembrane helix; Transport.
FT TRANSIT 1..56
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 57..597
FT /note="Mitochondrial inner membrane magnesium transporter
FT mrs2"
FT /id="PRO_0000043240"
FT TRANSMEM 423..443
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 462..482
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 552..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 447..450
FT /note="YGMN"
FT COMPBIAS 559..580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 597 AA; 65209 MW; 467E4F5D0A5C00AD CRC64;
MLSSSHLKPS APSATLLRFL RSQSDFLSVN SSRCARPSRS KPYVHQILPC NASSRASSTW
TCTASAPHRT TLQTSLVRTP TPAARSHSSS RPRLWLCAGQ AGRSSSIFPL SNAPYSRSAS
TKSRPLLRRL LDLRRSNSSA DKHNRGGPAL IDDGTEGGFT IGRGLAAKAT NEPRLRCTEF
DKNGNVTLVN GEFKKSELIA KYGLLPRDLR KIDSSTLPHI LVRPSAILIN LLHLRVLIKH
DRVLVFDAYG STDSYMQSLF VYDLEGKLQQ KQTGGFGALP YEFRALEAVL ISVTTGLEEE
FNGVREPVVR VLRALEEDID RDKLRHLLIY SKKLGTFEQK ARLVRDAIDD LLEADDDLAA
MYLTERANGV QREEDDHQEV EMLLESYHKV CDEIVQASGN LVTSIRNTEE VVKAILDANR
NSLMLLDLKF SIGTLGLATG TLFSALYGMN LKNFIEESDL GFGAVSMTCF MITAVVCVYG
LAKLRKLQRV RMWGEAGVGG APLTPLTTRS GILSGHRSNW RADSIEPVWG SLPGEARTER
IKRLRETAAA AAARSASADA TAQRASALRS SANANGGAPK GSEHSPTRET EASGSSA
