ID   MRS2_CANGA              Reviewed;         456 AA.
AC   Q6FV22;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Mitochondrial inner membrane magnesium transporter MRS2;
DE   AltName: Full=RNA-splicing protein MRS2;
DE   Flags: Precursor;
GN   Name=MRS2; OrderedLocusNames=CAGL0E05368g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: High-conductance magnesium-selective channel that mediates
CC       the influx of magnesium into the mitochondrial matrix. Essential for
CC       the splicing of mRNA group II introns in mitochondria by affecting
CC       mitochondrial magnesium concentrations, which are critical for group II
CC       intron splicing. It also suppresses a variety of mitochondrial intron
CC       mutations and its absence may disturb the assembly of mitochondrial
CC       membrane complexes. {ECO:0000250|UniProtKB:Q01926}.
CC   -!- SUBUNIT: Homopentamer. Forms homooligomers. Interacts with MFM1.
CC       {ECO:0000250|UniProtKB:Q01926}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q01926}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q01926}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC       family. {ECO:0000305}.
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DR   EMBL; CR380951; CAG58841.1; -; Genomic_DNA.
DR   RefSeq; XP_445922.1; XM_445922.1.
DR   AlphaFoldDB; Q6FV22; -.
DR   SMR; Q6FV22; -.
DR   STRING; 5478.XP_445922.1; -.
DR   EnsemblFungi; CAG58841; CAG58841; CAGL0E05368g.
DR   GeneID; 2887323; -.
DR   KEGG; cgr:CAGL0E05368g; -.
DR   CGD; CAL0128950; CAGL0E05368g.
DR   VEuPathDB; FungiDB:CAGL0E05368g; -.
DR   eggNOG; KOG2662; Eukaryota.
DR   HOGENOM; CLU_025144_1_0_1; -.
DR   InParanoid; Q6FV22; -.
DR   OMA; TQHDVEG; -.
DR   Proteomes; UP000002428; Chromosome E.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0045016; P:mitochondrial magnesium ion transmembrane transport; ISS:UniProtKB.
DR   CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR   InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR   InterPro; IPR039204; MRS2-like.
DR   PANTHER; PTHR13890; PTHR13890; 1.
DR   Pfam; PF01544; CorA; 1.
PE   3: Inferred from homology;
KW   Ion transport; Magnesium; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix; Transport.
FT   TRANSIT         1..38
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           39..456
FT                   /note="Mitochondrial inner membrane magnesium transporter
FT                   MRS2"
FT                   /id="PRO_0000043243"
FT   TRANSMEM        326..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           350..353
FT                   /note="YGMN"
SQ   SEQUENCE   456 AA;  52212 MW;  02AD4C36EF1DCA64 CRC64;
     MRPLVRYRLI PWCLRQAVCQ PVSKPIGYRL ISTRGGNRSP QGKKTIPLLN KPESSNVGAF
     PSAHQQLLSL KPITPNDSFI SSTVFDSKGA IVAVSKKFQK WEFLRKHALY PRDLRKIDTS
     SVDIIPSIQV KPNNCIVLNM LHIKALIEKD RVYVFDTVDP SSAVKLGVLM YDLESKLSPK
     MGTQVQYYEH RALESILINI MSSLEAEFKL HYSICGQILI DLENEVNRDK LRELLIKSKN
     LTLFYQKSLL IREVLDELLE SDDDLASLYL TVKKTEEDDF SDLEMLLETY YTQCDEYVQQ
     AESLIQDIKS TEEIVNIILD ANRNSLMLLE LKITIYTLGF TVATLVPAFY GMNLKNFIEE
     SYLGFGAVVV FSILSAYLVT RANFKALKSV TKLTMLKSSN PSQASYNMKT NSTLRPALAR
     IRGLFKWRKN PDSNGQPIWN KQDRDVIWKW LMDEKK