ID   MRS2_DEBHA              Reviewed;         476 AA.
AC   Q6BX67;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Mitochondrial inner membrane magnesium transporter MRS2;
DE   AltName: Full=RNA-splicing protein MRS2;
DE   Flags: Precursor;
GN   Name=MRS2; OrderedLocusNames=DEHA2B05566g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: High-conductance magnesium-selective channel that mediates
CC       the influx of magnesium into the mitochondrial matrix. Essential for
CC       the splicing of mRNA group II introns in mitochondria by affecting
CC       mitochondrial magnesium concentrations, which are critical for group II
CC       intron splicing. It also suppresses a variety of mitochondrial intron
CC       mutations and its absence may disturb the assembly of mitochondrial
CC       membrane complexes. {ECO:0000250|UniProtKB:Q01926}.
CC   -!- SUBUNIT: Homopentamer. Forms homooligomers. Interacts with MFM1.
CC       {ECO:0000250|UniProtKB:Q01926}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q01926}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q01926}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG85197.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CR382134; CAG85197.2; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_457202.2; XM_457202.2.
DR   AlphaFoldDB; Q6BX67; -.
DR   SMR; Q6BX67; -.
DR   STRING; 4959.XP_457202.2; -.
DR   PRIDE; Q6BX67; -.
DR   EnsemblFungi; CAG85197; CAG85197; DEHA2B05566g.
DR   GeneID; 2913155; -.
DR   KEGG; dha:DEHA2B05566g; -.
DR   eggNOG; KOG2662; Eukaryota.
DR   HOGENOM; CLU_025144_1_0_1; -.
DR   InParanoid; Q6BX67; -.
DR   OrthoDB; 1363588at2759; -.
DR   Proteomes; UP000000599; Chromosome B.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0045016; P:mitochondrial magnesium ion transmembrane transport; ISS:UniProtKB.
DR   CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR   InterPro; IPR039204; MRS2-like.
DR   PANTHER; PTHR13890; PTHR13890; 1.
PE   3: Inferred from homology;
KW   Ion transport; Magnesium; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix; Transport.
FT   TRANSIT         1..20
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..476
FT                   /note="Mitochondrial inner membrane magnesium transporter
FT                   MRS2"
FT                   /id="PRO_0000043244"
FT   TRANSMEM        349..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        385..405
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           373..376
FT                   /note="YGMN"
SQ   SEQUENCE   476 AA;  54591 MW;  672DE93A52C0BEA5 CRC64;
     MWTSLRHLKC SIPRQSINRC SSGLSKQFFK YKSTVSRNQD ILKKITDTNT HAMNTADIPE
     GISESFVDHQ FEPNKLVPTN DKKIIYNRLK PITPNDSYVS CTIFDIKGNI TAVSRKYPKM
     KFLKGNDLFP RDLRKIDTSS IDVVPSIMVR SPNCILVNLL HIKAIIKKDS VMVFDTSTPS
     IATKLGLFMY DLEMKLKLPS GNICYEFRAL ESILISVMSY LEADLRNHLQ GCGLILAELE
     DEIDRNKLQD LLIKSKKLSS FYQKAVLIRN VLEELLDNDE DLAGMYLTDP IKFDPTIENP
     TDFADLEMML ESYYKQCDEF VQQAGSLIND IKATEEIVNI ILDTNRNSLM LFELKITVYT
     LGFTVATLLP AFYGMNLKNY IEESTFGFGA VAVFSIIQGL LIIMLSFRKL RKVQKLTMMD
     GAGNHLHHSS SPIGLMNKDK WYYRLFYGNR HTKYDRPTPK ESDVIWRMIN DDKPLK