ID   MRS2_KLULA              Reviewed;         442 AA.
AC   Q6CLJ5;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Mitochondrial inner membrane magnesium transporter MRS2;
DE   AltName: Full=RNA-splicing protein MRS2;
DE   Flags: Precursor;
GN   Name=MRS2; OrderedLocusNames=KLLA0F02519g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: High-conductance magnesium-selective channel that mediates
CC       the influx of magnesium into the mitochondrial matrix. Essential for
CC       the splicing of mRNA group II introns in mitochondria by affecting
CC       mitochondrial magnesium concentrations, which are critical for group II
CC       intron splicing. It also suppresses a variety of mitochondrial intron
CC       mutations and its absence may disturb the assembly of mitochondrial
CC       membrane complexes. {ECO:0000250|UniProtKB:Q01926}.
CC   -!- SUBUNIT: Homopentamer. Forms homooligomers. Interacts with MFM1.
CC       {ECO:0000250|UniProtKB:Q01926}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q01926}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q01926}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC       family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG97901.1; -; Genomic_DNA.
DR   RefSeq; XP_455194.1; XM_455194.1.
DR   AlphaFoldDB; Q6CLJ5; -.
DR   SMR; Q6CLJ5; -.
DR   STRING; 28985.XP_455194.1; -.
DR   EnsemblFungi; CAG97901; CAG97901; KLLA0_F02519g.
DR   GeneID; 2894913; -.
DR   KEGG; kla:KLLA0_F02519g; -.
DR   eggNOG; KOG2662; Eukaryota.
DR   HOGENOM; CLU_025144_1_0_1; -.
DR   InParanoid; Q6CLJ5; -.
DR   OMA; TQHDVEG; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0045016; P:mitochondrial magnesium ion transmembrane transport; ISS:UniProtKB.
DR   CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR   InterPro; IPR045863; CorA_TM1_TM2.
DR   InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR   InterPro; IPR039204; MRS2-like.
DR   PANTHER; PTHR13890; PTHR13890; 1.
DR   Pfam; PF01544; CorA; 1.
DR   SUPFAM; SSF144083; SSF144083; 1.
PE   3: Inferred from homology;
KW   Ion transport; Magnesium; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix; Transport.
FT   TRANSIT         1..15
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..442
FT                   /note="Mitochondrial inner membrane magnesium transporter
FT                   MRS2"
FT                   /id="PRO_0000043246"
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           332..335
FT                   /note="YGMN"
SQ   SEQUENCE   442 AA;  50771 MW;  69C2C8626127A360 CRC64;
     MYFRFGKGLQ IQLRHSSKAV RSQLRWNSTT KLIKPIASTQ HPFLVKPVTP HESYVSCTIF
     NEKGDVTAVS HKFPKWEFLQ KYGLYPRDLR KIDSSTIDVI PSFVIKPKCI LVNVLHIKAM
     IQKDKVFVFD TTNPDAAIKL GVLMYDLESK LSQRNINYQG KSVSYQENYE HRALESILIN
     VMTCLETEYK YHHSVCGMIL NDLENQIDRD KLRDLLIKSK TLTAFAQKSV LLRDLLDELL
     ESDEDLAGMY LSEKKHPDAD DHSDLEMLLE TYYKQCDEYV QQSESLIQDI KSTEEIVNII
     LDANRNSLLL FELKVTVYTL GFTVATLVPA FYGMNLKNFI EDSNWGFASV VGLSVAAAAV
     VTITNMRALR SVTKLTLLNN HTGANNKKHL ANAKLALDKE IPTFWDRWLT SARVLWSGRE
     VLYKDGSKRD MIWKWLVDDD KK