MRS2_MOUSE
ID MRS2_MOUSE Reviewed; 434 AA.
AC Q5NCE8;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Magnesium transporter MRS2 homolog, mitochondrial;
DE AltName: Full=MRS2-like protein;
DE Flags: Precursor;
GN Name=Mrs2; Synonyms=Gm902, Mrs2l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=11401429; DOI=10.1006/geno.2000.6407;
RA Zsurka G., Gregan J., Schweyen R.J.;
RT "The human mitochondrial Mrs2 protein functionally substitutes for its
RT yeast homologue, a candidate magnesium transporter.";
RL Genomics 72:158-168(2001).
CC -!- FUNCTION: Magnesium transporter that mediates the influx of magnesium
CC into the mitochondrial matrix. Required for normal expression of the
CC mitochondrial respiratory complex I subunits.
CC {ECO:0000250|UniProtKB:Q9HD23}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q9HD23}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q9HD23}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC {ECO:0000269|PubMed:11401429}.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAI35077.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL645533; CAI35077.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS26385.2; -.
DR RefSeq; NP_001013407.2; NM_001013389.2.
DR AlphaFoldDB; Q5NCE8; -.
DR SMR; Q5NCE8; -.
DR BioGRID; 237667; 1.
DR STRING; 10090.ENSMUSP00000021772; -.
DR PhosphoSitePlus; Q5NCE8; -.
DR EPD; Q5NCE8; -.
DR MaxQB; Q5NCE8; -.
DR PaxDb; Q5NCE8; -.
DR PeptideAtlas; Q5NCE8; -.
DR PRIDE; Q5NCE8; -.
DR ProteomicsDB; 295658; -.
DR Antibodypedia; 25267; 58 antibodies from 14 providers.
DR DNASU; 380836; -.
DR Ensembl; ENSMUST00000021772; ENSMUSP00000021772; ENSMUSG00000021339.
DR GeneID; 380836; -.
DR KEGG; mmu:380836; -.
DR UCSC; uc056ytg.1; mouse.
DR CTD; 57380; -.
DR MGI; MGI:2685748; Mrs2.
DR VEuPathDB; HostDB:ENSMUSG00000021339; -.
DR eggNOG; KOG2662; Eukaryota.
DR GeneTree; ENSGT00390000009988; -.
DR HOGENOM; CLU_047261_0_0_1; -.
DR InParanoid; Q5NCE8; -.
DR OMA; TRNNCII; -.
DR OrthoDB; 1363588at2759; -.
DR PhylomeDB; Q5NCE8; -.
DR TreeFam; TF328433; -.
DR Reactome; R-MMU-5223345; Miscellaneous transport and binding events.
DR BioGRID-ORCS; 380836; 1 hit in 70 CRISPR screens.
DR ChiTaRS; Mrs2; mouse.
DR PRO; PR:Q5NCE8; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q5NCE8; protein.
DR Bgee; ENSMUSG00000021339; Expressed in spermatocyte and 249 other tissues.
DR Genevisible; Q5NCE8; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0006089; P:lactate metabolic process; ISO:MGI.
DR GO; GO:0015693; P:magnesium ion transport; IBA:GO_Central.
DR GO; GO:0045016; P:mitochondrial magnesium ion transmembrane transport; ISS:UniProtKB.
DR CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR InterPro; IPR039204; MRS2-like.
DR PANTHER; PTHR13890; PTHR13890; 1.
PE 2: Evidence at transcript level;
KW Ion transport; Magnesium; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW Transmembrane; Transmembrane helix; Transport.
FT TRANSIT 1..53
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 54..434
FT /note="Magnesium transporter MRS2 homolog, mitochondrial"
FT /id="PRO_0000042839"
FT TOPO_DOM 54..328
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 329..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 352..363
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 382..434
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
SQ SEQUENCE 434 AA; 49299 MW; 38A4DD0088B82643 CRC64;
MECLRCLPGL LPRAAQPRRA LWTAVARLSL AACGGRATPL RSRSPKASST ARAAGDVLRF
RTSDASQATL ASVAQVFAVT KFDKEGNVTS FERKKTELYH ELALQARDLR FQHVMSITTR
NNRIIMRMEY LKAVITPECL LILDYRNLNL EHWLFRELPS QLAGEGQLVT YPLPFEFRAI
EALLQYWIST LRGRLSVLQP LILETLDALV DPKHSSVDRS KLHVLLQNGK SLSELETDIK
IFKESILELL DEEEMLEELC LTKWSDPHVF EKSSTGIDHA EEMELLLENY YRLAEDLSNE
ARELRVLIDD SQSIIFINLD SHRNVMMRLN LQLTMGTFSL SLFGLMGVAF GMNLESSLEE
DHRVFWLVTG IMFMGSGLIW RRLLSFLGRQ LEAPVPPVMT SLPKKTLLAN RRMDVKNSLR
PEGLGASRTI LASR
