ID   MRS2_PLAF7              Reviewed;         529 AA.
AC   Q8IIG4; A0A143ZZ84;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-SEP-2011, sequence version 2.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Mitochondrial inner membrane magnesium transporter MIT1;
DE   Flags: Precursor;
GN   Name=MIT1 {ECO:0000250|UniProtKB:A0A509AK04};
GN   ORFNames=PF11_0210, PF3D7_1120300;
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3D7;
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000305}
RP   SYNTHESIS OF 347-387, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX   PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA   Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA   Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA   Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT   "Rapid identification of malaria vaccine candidates based on alpha-helical
RT   coiled coil protein motif.";
RL   PLoS ONE 2:E645-E645(2007).
CC   -!- FUNCTION: Mitochondrial inner membrane magnesium transporter required
CC       for mitochondrial magnesium homeostasis (By similarity). Involved in
CC       the development of the sporozoite in the mosquito vector midgut (By
CC       similarity). {ECO:0000250|UniProtKB:A0A509AK04,
CC       ECO:0000250|UniProtKB:Q01926}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q01926}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q01926}.
CC   -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC       determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC       family. {ECO:0000305}.
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DR   EMBL; LN999945; CZT98865.1; -; Genomic_DNA.
DR   RefSeq; XP_001347881.2; XM_001347845.2.
DR   AlphaFoldDB; Q8IIG4; -.
DR   SMR; Q8IIG4; -.
DR   STRING; 5833.PF11_0210; -.
DR   EnsemblProtists; CZT98865; CZT98865; PF3D7_1120300.
DR   GeneID; 810757; -.
DR   KEGG; pfa:PF3D7_1120300; -.
DR   VEuPathDB; PlasmoDB:PF3D7_1120300; -.
DR   HOGENOM; CLU_633836_0_0_1; -.
DR   InParanoid; Q8IIG4; -.
DR   OMA; NNHNPTL; -.
DR   PhylomeDB; Q8IIG4; -.
DR   Proteomes; UP000001450; Chromosome 11.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015693; P:magnesium ion transport; IBA:GO_Central.
DR   CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR   InterPro; IPR039204; MRS2-like.
DR   PANTHER; PTHR13890; PTHR13890; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Ion transport; Magnesium; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix; Transport.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..529
FT                   /note="Mitochondrial inner membrane magnesium transporter
FT                   MIT1"
FT                   /id="PRO_0000364019"
FT   TOPO_DOM        ?..455
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        456..476
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        477..492
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        493..513
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        514..529
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   COILED          336..388
FT                   /evidence="ECO:0000255"
FT   COILED          416..450
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   529 AA;  63252 MW;  BFA089C3701B6416 CRC64;
     MFVWTHINKY TSRYINRYIL KFTRYESLRL CMLNFTSTIK NENKIYSKKN FNNVLMQNIK
     ITEDEEIICE QFFFSKYNLP YVLKIPFSDL RLIDTCNNNH NPTILIRKDM ILLRTGFLSC
     VIRYNELWLF EPREPLVIKA TNLIKQNLKI IYGFKGDMSS GVEIPLNELK DEKCQENVNM
     YEKNIRNDLY STYEKNISDD INDAKQKNMC SDINNIWSNH IKIDKKRIIS GNYSRLNRNN
     IWENDREINK KDIFNIKEKK NMNENDDICN KIKIVGKEEL NNNIKEDINY LNVENNFYRY
     KGNISFEFLC LDICMQLSIK EYENYLDTIN ITLRQKIQLQ QKKEENIEIN MLTNNLLREM
     MKIKNKLQKL SNLLNALRSN IEKILKNETD MKNMYLTTLN KISINKIKDY SDLEILLETH
     LQLTDELSGE LENMEEKITH YEELMRLNLD YNRNKFILLN AKISFSTLFC SICAVITSLF
     GMNLKNFIEH NDYAFFIVSI FITSWSIVGI YFTKNINTLL RFFDKYNVK