ID   MRS2_PONAB              Reviewed;         443 AA.
AC   Q5R447;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Magnesium transporter MRS2 homolog, mitochondrial;
DE   AltName: Full=MRS2-like protein;
DE   Flags: Precursor;
GN   Name=MRS2; Synonyms=MRS2L;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Magnesium transporter that mediates the influx of magnesium
CC       into the mitochondrial matrix. Required for normal expression of the
CC       mitochondrial respiratory complex I subunits.
CC       {ECO:0000250|UniProtKB:Q9HD23}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9HD23}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q9HD23}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC       family. {ECO:0000305}.
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DR   EMBL; CR861413; CAH93469.1; -; mRNA.
DR   RefSeq; NP_001127033.1; NM_001133561.1.
DR   AlphaFoldDB; Q5R447; -.
DR   SMR; Q5R447; -.
DR   STRING; 9601.ENSPPYP00000018202; -.
DR   GeneID; 100174059; -.
DR   KEGG; pon:100174059; -.
DR   CTD; 57380; -.
DR   eggNOG; KOG2662; Eukaryota.
DR   InParanoid; Q5R447; -.
DR   OrthoDB; 1363588at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0045016; P:mitochondrial magnesium ion transmembrane transport; ISS:UniProtKB.
DR   CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR   InterPro; IPR039204; MRS2-like.
DR   PANTHER; PTHR13890; PTHR13890; 1.
PE   2: Evidence at transcript level;
KW   Ion transport; Magnesium; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix; Transport.
FT   TRANSIT         1..49
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           50..443
FT                   /note="Magnesium transporter MRS2 homolog, mitochondrial"
FT                   /id="PRO_0000042840"
FT   TOPO_DOM        50..339
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        361..372
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        394..443
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   443 AA;  50244 MW;  1DC2C7DA71AC1820 CRC64;
     MECLRSLPCL LPRAMRLPRR TLCALALDLT SVAPPVAASG RRANLIGRSR AAQLCEPGRL
     RVAGEVHRFR TSDVSQATLA SVAPVFTVTK FDKQGNVTSF ERKKTELYQE LGLQARDLRF
     QHVMSITVRN NRIIMRMEYL KAVITPECLL ILDYRNLNLE QWLFRELPSQ LSGEGQLVTY
     PLPFEFRAIE ALLQYWINTL QGKLSVLQPL ILETLDALVD PKHSSVDKSK LHILLQNGKS
     LSELETDIKI FKESILEILD EEELLEELCV SKWSDPQVFE KSSAGIDHAE EMELLLENYY
     RLADDLSNAA RELRVLIDDS QSIIFINLGS HRNVMMRLNL QLTMGTFSLS LFGLMGVAFG
     MNLESSLEED HRIFWLITGI MFMGSGLIWR RLLSFLGRQL EAPLPPMMAS LPKKTLLADR
     SMELKNSLRL DGLGSGRSIL TNR