MRS2_RAT
ID MRS2_RAT Reviewed; 434 AA.
AC Q9ET09; Q4FZY6; Q5XIW5; Q9ET07; Q9ET08;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Magnesium transporter MRS2 homolog, mitochondrial;
DE AltName: Full=MRS2-like protein;
DE Flags: Precursor;
GN Name=Mrs2; Synonyms=Mrs2l, Rpt;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Soleus muscle;
RA Bosma T.J., Cooper G.S., Gardner R.C.;
RT "Putative mammalian magnesium transporters.";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Ovary, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Magnesium transporter that mediates the influx of magnesium
CC into the mitochondrial matrix. Required for normal expression of the
CC mitochondrial respiratory complex I subunits.
CC {ECO:0000250|UniProtKB:Q9HD23}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q9HD23}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q9HD23}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9ET09-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9ET09-2; Sequence=VSP_016213;
CC Name=3;
CC IsoId=Q9ET09-3; Sequence=VSP_016211, VSP_016212;
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH98916.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF288289; AAF99081.1; -; mRNA.
DR EMBL; AF288290; AAF99082.1; -; mRNA.
DR EMBL; AF288291; AAF99083.1; -; mRNA.
DR EMBL; BC083554; AAH83554.1; -; mRNA.
DR EMBL; BC098916; AAH98916.1; ALT_INIT; mRNA.
DR RefSeq; NP_076491.1; NM_024001.1. [Q9ET09-1]
DR RefSeq; XP_006253999.1; XM_006253937.3. [Q9ET09-2]
DR AlphaFoldDB; Q9ET09; -.
DR SMR; Q9ET09; -.
DR STRING; 10116.ENSRNOP00000023787; -.
DR PaxDb; Q9ET09; -.
DR PRIDE; Q9ET09; -.
DR Ensembl; ENSRNOT00000023787; ENSRNOP00000023787; ENSRNOG00000017545. [Q9ET09-1]
DR Ensembl; ENSRNOT00000110477; ENSRNOP00000083733; ENSRNOG00000017545. [Q9ET09-2]
DR GeneID; 79032; -.
DR KEGG; rno:79032; -.
DR UCSC; RGD:708529; rat. [Q9ET09-1]
DR CTD; 57380; -.
DR RGD; 708529; Mrs2.
DR eggNOG; KOG2662; Eukaryota.
DR GeneTree; ENSGT00390000009988; -.
DR HOGENOM; CLU_047261_0_0_1; -.
DR InParanoid; Q9ET09; -.
DR OMA; TRNNCII; -.
DR OrthoDB; 1363588at2759; -.
DR PhylomeDB; Q9ET09; -.
DR Reactome; R-RNO-5223345; Miscellaneous transport and binding events.
DR PRO; PR:Q9ET09; -.
DR Proteomes; UP000002494; Chromosome 17.
DR Bgee; ENSRNOG00000017545; Expressed in duodenum and 20 other tissues.
DR Genevisible; Q9ET09; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:RGD.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0006089; P:lactate metabolic process; IMP:RGD.
DR GO; GO:0015693; P:magnesium ion transport; IBA:GO_Central.
DR GO; GO:0045016; P:mitochondrial magnesium ion transmembrane transport; ISS:UniProtKB.
DR CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR InterPro; IPR039204; MRS2-like.
DR PANTHER; PTHR13890; PTHR13890; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Ion transport; Magnesium; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW Transmembrane; Transmembrane helix; Transport.
FT TRANSIT 1..28
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 29..434
FT /note="Magnesium transporter MRS2 homolog, mitochondrial"
FT /id="PRO_0000042841"
FT TOPO_DOM 29..330
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 352..363
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 385..434
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT VAR_SEQ 188..200
FT /note="INTLQGKLSILQP -> AMLLSRSTPFRGN (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_016211"
FT VAR_SEQ 201..434
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_016212"
FT VAR_SEQ 399..434
FT /note="MASLPKKTLLADRRMDVKNSLRPEGLGAGRTILASR -> VWTWGSQQHCWA
FT LLILGIESGSLGFSGHRLCDPVQVLLPFPSANPVCTVCFK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_016213"
SQ SEQUENCE 434 AA; 49365 MW; F57C178E96403F53 CRC64;
MECLRYLPRL LPRAAQSRSA LCMAAVRLSL AACCGRATPL TSGSQKAPST PRTAGDVYRF
RTSDASQATL ASVAQVFAVT KFDKEGNVTS FERKKTELYH ELALQARDLR FQHVMSITTR
NNRIIMRMEY LKAVITPEYL LILDYRNLNL EHWLFRELPS QLAGEGQLVT YPLPFEFRAI
EALLQYWINT LQGKLSILQP LILETLDALV DPKHSSVDRS KLHVLLQNGK SLSELETDIK
IFKESILELL DEEEMLEELC LTKWSDPHVF EQSSTGIDHA EEMELLLENY YRLADDLSNE
ARELRVLIDD SQSIIFINLD SHRNVMMRLN LQLTMGTFSL SLFGLMGVAF GMNLESSLEE
DHRVFWLITG IMFMGSGLIW RRLLSFLGRQ LEAPLPPVMA SLPKKTLLAD RRMDVKNSLR
PEGLGAGRTI LASR
