MRS2_SCHPO
ID MRS2_SCHPO Reviewed; 422 AA.
AC P87149;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Mitochondrial inner membrane magnesium transporter mrs2;
DE AltName: Full=RNA-splicing protein mrs2;
DE Flags: Precursor;
GN Name=mrs2; ORFNames=SPBC25H2.08c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: High-conductance magnesium-selective channel that mediates
CC the influx of magnesium into the mitochondrial matrix. Essential for
CC the splicing of mRNA group II introns in mitochondria by affecting
CC mitochondrial magnesium concentrations, which are critical for group II
CC intron splicing. It also suppresses a variety of mitochondrial intron
CC mutations and its absence may disturb the assembly of mitochondrial
CC membrane complexes. {ECO:0000250|UniProtKB:Q01926}.
CC -!- SUBUNIT: Homopentamer. Forms homooligomers. Interacts with MFM1.
CC {ECO:0000250|UniProtKB:Q01926}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q01926}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q01926}.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC family. {ECO:0000305}.
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DR EMBL; CU329671; CAB08784.1; -; Genomic_DNA.
DR PIR; T40003; T40003.
DR RefSeq; NP_596358.1; NM_001022279.2.
DR AlphaFoldDB; P87149; -.
DR SMR; P87149; -.
DR BioGRID; 276914; 3.
DR STRING; 4896.SPBC25H2.08c.1; -.
DR PaxDb; P87149; -.
DR PRIDE; P87149; -.
DR EnsemblFungi; SPBC25H2.08c.1; SPBC25H2.08c.1:pep; SPBC25H2.08c.
DR GeneID; 2540385; -.
DR KEGG; spo:SPBC25H2.08c; -.
DR PomBase; SPBC25H2.08c; mrs2.
DR VEuPathDB; FungiDB:SPBC25H2.08c; -.
DR eggNOG; KOG2662; Eukaryota.
DR HOGENOM; CLU_025144_1_2_1; -.
DR InParanoid; P87149; -.
DR OMA; TRNNCII; -.
DR PhylomeDB; P87149; -.
DR Reactome; R-SPO-5223345; Miscellaneous transport and binding events.
DR PRO; PR:P87149; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015693; P:magnesium ion transport; IBA:GO_Central.
DR GO; GO:0045016; P:mitochondrial magnesium ion transmembrane transport; ISS:UniProtKB.
DR CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR InterPro; IPR039204; MRS2-like.
DR PANTHER; PTHR13890; PTHR13890; 1.
DR Pfam; PF01544; CorA; 1.
PE 3: Inferred from homology;
KW Ion transport; Magnesium; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW Transmembrane; Transmembrane helix; Transport.
FT TRANSIT 1..49
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 50..422
FT /note="Mitochondrial inner membrane magnesium transporter
FT mrs2"
FT /id="PRO_0000043248"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOTIF 355..358
FT /note="YGMN"
SQ SEQUENCE 422 AA; 47888 MW; 573A3371720262EB CRC64;
MVLIVGFNLR TSIASFSPIC RSLFLFPKYR SRIIRPVVLL EKPFDKHFYA TDSNPLITGF
PETSKNCPPS VAATKNRLLM NCTEFDDHGN VRVISGDFKK MDLCKQNGLL PRDLRKLNTS
INSIVPVILV REGSILINLL HIRALIKANS VLLFDVYGSQ HSHSQSQFIY ELEGRLKQKS
SDFGWLPYEM RALETILVSV VNTLDSELHV LHNLVSDLLA DFELDINQER LRTLLIFSKR
LSGFLKKATL IRDVLDELLE QDQDLAGMYL TERLKTGKPR DLDKHDEVEL LLETYCKQVD
EIVQQTDNLV GNIRSTEEIC NIMLDANRNS LMLLGLKLSA MTLGLGFGAV VASLYGMNLQ
NGLENHPYAF YITTGSIFAF AAFLSSLGIL KIRRLKRIQM ALYHRCNLPI SLDPRSLRPP
YL
