ID   MRS2_YARLI              Reviewed;         419 AA.
AC   Q6C2P2;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Mitochondrial inner membrane magnesium transporter MRS2;
DE   AltName: Full=RNA-splicing protein MRS2;
DE   Flags: Precursor;
GN   Name=MRS2; OrderedLocusNames=YALI0F06248g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: High-conductance magnesium-selective channel that mediates
CC       the influx of magnesium into the mitochondrial matrix. Essential for
CC       the splicing of mRNA group II introns in mitochondria by affecting
CC       mitochondrial magnesium concentrations, which are critical for group II
CC       intron splicing. It also suppresses a variety of mitochondrial intron
CC       mutations and its absence may disturb the assembly of mitochondrial
CC       membrane complexes. {ECO:0000250|UniProtKB:Q01926}.
CC   -!- SUBUNIT: Homopentamer. Forms homooligomers. Interacts with MFM1.
CC       {ECO:0000250|UniProtKB:Q01926}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q01926}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q01926}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC       family. {ECO:0000305}.
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DR   EMBL; CR382132; CAG77877.1; -; Genomic_DNA.
DR   RefSeq; XP_505070.1; XM_505070.1.
DR   AlphaFoldDB; Q6C2P2; -.
DR   SMR; Q6C2P2; -.
DR   STRING; 4952.CAG77877; -.
DR   EnsemblFungi; CAG77877; CAG77877; YALI0_F06248g.
DR   GeneID; 2908419; -.
DR   KEGG; yli:YALI0F06248g; -.
DR   VEuPathDB; FungiDB:YALI0_F06248g; -.
DR   HOGENOM; CLU_025144_1_0_1; -.
DR   InParanoid; Q6C2P2; -.
DR   OMA; HASPTIA; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015693; P:magnesium ion transport; IBA:GO_Central.
DR   GO; GO:0045016; P:mitochondrial magnesium ion transmembrane transport; IBA:GO_Central.
DR   CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR   InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR   InterPro; IPR039204; MRS2-like.
DR   PANTHER; PTHR13890; PTHR13890; 1.
DR   Pfam; PF01544; CorA; 1.
PE   3: Inferred from homology;
KW   Ion transport; Magnesium; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix; Transport.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..419
FT                   /note="Mitochondrial inner membrane magnesium transporter
FT                   MRS2"
FT                   /id="PRO_0000043239"
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        328..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           314..317
FT                   /note="YGMN"
SQ   SEQUENCE   419 AA;  47612 MW;  FDC2C1E14F921352 CRC64;
     MDEEEHKDHQ EEEDPHHFAF SDNYSEAVLG GEISATVFDV TGKVVHVAHK MTKYEFLLEH
     GLYPRDLRNI DPSPVSIIPS ILARGRKGAG RCILVNLLHI KALILHDKVL IFDTHSKNKS
     DTHRLGMFLY ELENKLKPTI NPEKMHTDMT VLPFELRVLE AILVNVMTTL DGELQVHLKT
     LNEILVGLED HVDREQLKEL LIGNKNVSRF YQKAVLIRDV LEELLESDDD LQQLYLGTHP
     KEGLAEVELL IESYCKQADE IVQQASNVRS HIRSTEEIVN IIVDANRNAL MLLELKVTIV
     TVGFAVGAFV AALYGMNLEN FIEETNEGMV LVVGVACLGG LLVTWFNLTK LHKTQKIAMF
     SNAATHTASK PYMLQWIIGL LRRKRTKSRF DNIDMSRPKM KGKKSNILHQ LTKMTGKRR