ID   MRT4_CHATD              Reviewed;         270 AA.
AC   G0S616;
DT   29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT   29-OCT-2014, sequence version 2.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Ribosome assembly factor mrt4 {ECO:0000250|UniProtKB:P33201};
DE   AltName: Full=mRNA turnover protein 4 {ECO:0000250|UniProtKB:P33201};
GN   ORFNames=CTHT_0025680 {ECO:0000312|EMBL:EGS20732.1};
OS   Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=759272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 1495 / CBS 144.50 / IMI 039719;
RX   PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA   Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA   Arumugam M., Bork P., Hurt E.;
RT   "Insight into structure and assembly of the nuclear pore complex by
RT   utilizing the genome of a eukaryotic thermophile.";
RL   Cell 146:277-289(2011).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS), IDENTIFICATION OF FRAMESHIFT, AND
RP   SEQUENCE REVISION TO 13; 139; 228 AND 259.
RX   PubMed=24662372; DOI=10.1038/ncomms4491;
RA   Leidig C., Thoms M., Holdermann I., Bradatsch B., Berninghausen O.,
RA   Bange G., Sinning I., Hurt E., Beckmann R.;
RT   "60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein
RT   particle.";
RL   Nat. Commun. 5:3491-3491(2014).
CC   -!- FUNCTION: Component of the ribosome assembly machinery. Nuclear paralog
CC       of the ribosomal protein P0, it binds pre-60S subunits at an early
CC       stage of assembly in the nucleolus, and is replaced by P0 in
CC       cytoplasmic pre-60S subunits and mature 80S ribosomes.
CC       {ECO:0000250|UniProtKB:P33201}.
CC   -!- SUBUNIT: Associates with the pre-60S ribosomal particle.
CC       {ECO:0000250|UniProtKB:P33201}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:P33201}. Cytoplasm
CC       {ECO:0000250|UniProtKB:P33201}. Note=Shuttles between the nucleus and
CC       the cytoplasm. {ECO:0000250|UniProtKB:P33201}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL10 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EGS20732.1; Type=Erroneous gene model prediction; Evidence={ECO:0000303|PubMed:24662372, ECO:0000305};
CC       Sequence=EGS20732.1; Type=Frameshift; Evidence={ECO:0000303|PubMed:24662372, ECO:0000305};
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DR   EMBL; GL988041; EGS20732.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_006693028.1; XM_006692965.1.
DR   PDB; 4NWB; X-ray; 1.80 A; A=1-270.
DR   PDBsum; 4NWB; -.
DR   AlphaFoldDB; G0S616; -.
DR   SMR; G0S616; -.
DR   STRING; 759272.G0S616; -.
DR   EnsemblFungi; EGS20732; EGS20732; CTHT_0025680.
DR   GeneID; 18256606; -.
DR   KEGG; cthr:CTHT_0025680; -.
DR   HOGENOM; CLU_071690_3_0_1; -.
DR   OrthoDB; 1181992at2759; -.
DR   Proteomes; UP000008066; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IEA:InterPro.
DR   CDD; cd05796; Ribosomal_P0_like; 1.
DR   Gene3D; 3.30.70.1730; -; 1.
DR   Gene3D; 3.90.105.20; -; 1.
DR   InterPro; IPR033867; Mrt4.
DR   InterPro; IPR043141; Ribosomal_L10-like_sf.
DR   InterPro; IPR001790; Ribosomal_L10P.
DR   InterPro; IPR043164; RL10_insert_sf.
DR   InterPro; IPR040637; RL10P_insert.
DR   Pfam; PF00466; Ribosomal_L10; 1.
DR   Pfam; PF17777; RL10P_insert; 1.
DR   SUPFAM; SSF160369; SSF160369; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Nucleus; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein.
FT   CHAIN           1..270
FT                   /note="Ribosome assembly factor mrt4"
FT                   /id="PRO_0000430590"
FT   REGION          234..270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        238..258
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        13
FT                   /note="T -> I (in Ref. 1; EGS20732)"
FT   CONFLICT        139
FT                   /note="P -> T (in Ref. 1; EGS20732)"
FT   CONFLICT        228
FT                   /note="S -> N (in Ref. 1; EGS20732)"
FT   CONFLICT        259
FT                   /note="M -> I (in Ref. 1; EGS20732)"
FT   HELIX           8..15
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   HELIX           26..33
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   HELIX           34..36
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   STRAND          38..47
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   HELIX           50..59
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   TURN            60..62
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   STRAND          63..66
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   HELIX           70..77
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   TURN            81..83
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   HELIX           89..95
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   STRAND          98..107
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   HELIX           109..118
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   STRAND          121..123
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   STRAND          135..137
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   STRAND          139..141
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   TURN            144..147
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   HELIX           151..153
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   HELIX           159..161
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   HELIX           162..167
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   STRAND          172..175
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   STRAND          178..181
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   STRAND          192..195
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   HELIX           203..211
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   STRAND          217..228
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   TURN            229..231
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   STRAND          234..236
FT                   /evidence="ECO:0007829|PDB:4NWB"
FT   HELIX           238..241
FT                   /evidence="ECO:0007829|PDB:4NWB"
SQ   SEQUENCE   270 AA;  30480 MW;  2458BF4ED266B410 CRC64;
     MPKSKRARVY HLTQVNKKGR EAKERLFSNI RETIPKYQHC FVFSVDNMRN NYLKDVRHEL
     NDCRIFFGKT KLMARALGTT PEEEQADGLH RLTRYLTGTV GLLFTNRDPA DIESYFSNLS
     QVDFARAGTV APRTVTVPPG IVYSTGGEVP PEHDVPVSHT LEPELRRLGM PVRMIKGKVC
     LGDEKGEASE GYTICKEGEV LDSRQTRLLK LFSICLSEFK VSLLGYWSSA SGEVTELEAG
     KTRPKREGNR RQAMNGDEMD EDQSSDEDSD