MRT4_DICDI
ID MRT4_DICDI Reviewed; 223 AA.
AC Q86HD3; Q551M6;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Ribosome assembly factor mrt4 {ECO:0000250|UniProtKB:P33201};
DE AltName: Full=mRNA turnover protein 4 {ECO:0000250|UniProtKB:P33201};
GN Name=mrt4 {ECO:0000250|UniProtKB:P33201};
GN ORFNames=DDB_G0276411 {ECO:0000312|dictyBase:DDB_G0276411};
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the ribosome assembly machinery. Nuclear paralog
CC of the ribosomal protein P0, it binds pre-60S subunits at an early
CC stage of assembly in the nucleolus, and is replaced by P0 in
CC cytoplasmic pre-60S subunits and mature 80S ribosomes.
CC {ECO:0000250|UniProtKB:P33201}.
CC -!- SUBUNIT: Associates with the pre-60S ribosomal particle.
CC {ECO:0000250|UniProtKB:P33201}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:P33201}. Cytoplasm
CC {ECO:0000250|UniProtKB:P33201}. Note=Shuttles between the nucleus and
CC the cytoplasm. {ECO:0000250|UniProtKB:P33201}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL10 family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000015; EAL69159.1; -; Genomic_DNA.
DR RefSeq; XP_643104.1; XM_638012.1.
DR AlphaFoldDB; Q86HD3; -.
DR SMR; Q86HD3; -.
DR STRING; 44689.DDB0252706; -.
DR PaxDb; Q86HD3; -.
DR EnsemblProtists; EAL69159; EAL69159; DDB_G0276411.
DR GeneID; 8620508; -.
DR KEGG; ddi:DDB_G0276411; -.
DR dictyBase; DDB_G0276411; mrt4.
DR eggNOG; KOG0816; Eukaryota.
DR HOGENOM; CLU_071690_3_0_1; -.
DR InParanoid; Q86HD3; -.
DR OMA; LEWAENY; -.
DR PhylomeDB; Q86HD3; -.
DR PRO; PR:Q86HD3; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; IBA:GO_Central.
DR GO; GO:0000027; P:ribosomal large subunit assembly; IEA:InterPro.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR CDD; cd05796; Ribosomal_P0_like; 1.
DR Gene3D; 3.30.70.1730; -; 1.
DR Gene3D; 3.90.105.20; -; 1.
DR InterPro; IPR033867; Mrt4.
DR InterPro; IPR043141; Ribosomal_L10-like_sf.
DR InterPro; IPR001790; Ribosomal_L10P.
DR InterPro; IPR043164; RL10_insert_sf.
DR InterPro; IPR040637; RL10P_insert.
DR Pfam; PF00466; Ribosomal_L10; 1.
DR Pfam; PF17777; RL10P_insert; 1.
DR SUPFAM; SSF160369; SSF160369; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome; Ribosome biogenesis.
FT CHAIN 1..223
FT /note="Ribosome assembly factor mrt4"
FT /id="PRO_0000327750"
SQ SEQUENCE 223 AA; 25836 MW; 808DBB844E1A7E4E CRC64;
MVKSKRNVVV NMTKVTKNPG EKKKKLVSTI KDIVDQYKFI YLFTFENMRN NKLKSVRTEW
STSKFLFGKN KVLSVGLGKS EEDELKPNLH KLTEHLEGEC GLFFTNEPKD KVFEYFTNYS
EKDFPRSGFV SEETITIKEG PIVGMTHSME TYLRGLGLPT TLKNGVIFVD REYTLCEAGV
AVTPEQSQLL KLFNHEISEF KFHIKGFWNE DEFTLCEEES QEE
