ID   MRT4_NEUCR              Reviewed;         252 AA.
AC   Q7S302;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Ribosome assembly factor mrt4 {ECO:0000250|UniProtKB:P33201};
DE   AltName: Full=mRNA turnover protein 4 {ECO:0000250|UniProtKB:P33201};
GN   Name=mrt4 {ECO:0000250|UniProtKB:P33201}; ORFNames=NCU07547;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Component of the ribosome assembly machinery. Nuclear paralog
CC       of the ribosomal protein P0, it binds pre-60S subunits at an early
CC       stage of assembly in the nucleolus, and is replaced by P0 in
CC       cytoplasmic pre-60S subunits and mature 80S ribosomes.
CC       {ECO:0000250|UniProtKB:P33201}.
CC   -!- SUBUNIT: Associates with the pre-60S ribosomal particle.
CC       {ECO:0000250|UniProtKB:P33201}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:P33201}. Cytoplasm
CC       {ECO:0000250|UniProtKB:P33201}. Note=Shuttles between the nucleus and
CC       the cytoplasm. {ECO:0000250|UniProtKB:P33201}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL10 family.
CC       {ECO:0000305}.
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DR   EMBL; CM002238; EAA29824.1; -; Genomic_DNA.
DR   RefSeq; XP_959060.1; XM_953967.2.
DR   AlphaFoldDB; Q7S302; -.
DR   SMR; Q7S302; -.
DR   STRING; 5141.EFNCRP00000007843; -.
DR   EnsemblFungi; EAA29824; EAA29824; NCU07547.
DR   GeneID; 3875198; -.
DR   KEGG; ncr:NCU07547; -.
DR   VEuPathDB; FungiDB:NCU07547; -.
DR   HOGENOM; CLU_071690_0_0_1; -.
DR   InParanoid; Q7S302; -.
DR   OMA; LEWAENY; -.
DR   Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:EnsemblFungi.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR   GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; IBA:GO_Central.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IEA:InterPro.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR   GO; GO:0000055; P:ribosomal large subunit export from nucleus; IEA:EnsemblFungi.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   CDD; cd05796; Ribosomal_P0_like; 1.
DR   Gene3D; 3.30.70.1730; -; 1.
DR   Gene3D; 3.90.105.20; -; 1.
DR   InterPro; IPR033867; Mrt4.
DR   InterPro; IPR043141; Ribosomal_L10-like_sf.
DR   InterPro; IPR001790; Ribosomal_L10P.
DR   InterPro; IPR043164; RL10_insert_sf.
DR   InterPro; IPR040637; RL10P_insert.
DR   Pfam; PF00466; Ribosomal_L10; 1.
DR   Pfam; PF17777; RL10P_insert; 1.
DR   SUPFAM; SSF160369; SSF160369; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..252
FT                   /note="Ribosome assembly factor mrt4"
FT                   /id="PRO_0000154813"
SQ   SEQUENCE   252 AA;  28329 MW;  4A8E8B17E6DFD43D CRC64;
     MPKSKRAKVY NLTQVTKKNR EQKEKLFENI RECIPNYQHC FVFSIDNMRN NYLKDVRKEL
     NDCRIFFGKT KLTARALGTT PEDAQADGLD KLSKYLSGSV GLIFTNRDPS EIKDYFVNLT
     QVDFARAGSV ATRTITIPSG PLYSTGGEVP AEHDVPVSHT LEPELRRLGM PTRMVKGKVC
     LGDEAGEGDD YVICKEGETL DSRQTRLLKL FSICLSEFRV KLLAYWSAAS GEVTELEKPG
     EAGAEEMEED DE