MRT4_SCHPO
ID MRT4_SCHPO Reviewed; 241 AA.
AC Q9USZ6;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Ribosome assembly factor mrt4 {ECO:0000250|UniProtKB:P33201};
DE AltName: Full=mRNA turnover protein 4 {ECO:0000250|UniProtKB:P33201};
GN Name=mrt4 {ECO:0000250|UniProtKB:P33201};
GN ORFNames=SPBC11G11.03 {ECO:0000312|PomBase:SPBC11G11.03};
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Component of the ribosome assembly machinery. Nuclear paralog
CC of the ribosomal protein P0, it binds pre-60S subunits at an early
CC stage of assembly in the nucleolus, and is replaced by P0 in
CC cytoplasmic pre-60S subunits and mature 80S ribosomes.
CC {ECO:0000250|UniProtKB:P33201}.
CC -!- SUBUNIT: Associates with the pre-60S ribosomal particle.
CC {ECO:0000250|UniProtKB:P33201}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
CC Cytoplasm {ECO:0000250|UniProtKB:P33201}. Note=Shuttles between the
CC nucleus and the cytoplasm. {ECO:0000250|UniProtKB:P33201}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL10 family.
CC {ECO:0000305}.
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DR EMBL; CU329671; CAB59805.1; -; Genomic_DNA.
DR PIR; T39330; T39330.
DR RefSeq; NP_595721.1; NM_001021619.2.
DR AlphaFoldDB; Q9USZ6; -.
DR SMR; Q9USZ6; -.
DR BioGRID; 276457; 26.
DR STRING; 4896.SPBC11G11.03.1; -.
DR MaxQB; Q9USZ6; -.
DR PaxDb; Q9USZ6; -.
DR EnsemblFungi; SPBC11G11.03.1; SPBC11G11.03.1:pep; SPBC11G11.03.
DR GeneID; 2539913; -.
DR KEGG; spo:SPBC11G11.03; -.
DR PomBase; SPBC11G11.03; mrt4.
DR VEuPathDB; FungiDB:SPBC11G11.03; -.
DR eggNOG; KOG0816; Eukaryota.
DR HOGENOM; CLU_071690_0_0_1; -.
DR InParanoid; Q9USZ6; -.
DR OMA; LEWAENY; -.
DR PhylomeDB; Q9USZ6; -.
DR PRO; PR:Q9USZ6; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; ISO:PomBase.
DR GO; GO:0000027; P:ribosomal large subunit assembly; ISO:PomBase.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; ISO:PomBase.
DR CDD; cd05796; Ribosomal_P0_like; 1.
DR Gene3D; 3.30.70.1730; -; 1.
DR Gene3D; 3.90.105.20; -; 1.
DR InterPro; IPR033867; Mrt4.
DR InterPro; IPR043141; Ribosomal_L10-like_sf.
DR InterPro; IPR001790; Ribosomal_L10P.
DR InterPro; IPR043164; RL10_insert_sf.
DR InterPro; IPR040637; RL10P_insert.
DR Pfam; PF00466; Ribosomal_L10; 1.
DR Pfam; PF17777; RL10P_insert; 1.
DR SUPFAM; SSF160369; SSF160369; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome; Ribosome biogenesis.
FT CHAIN 1..241
FT /note="Ribosome assembly factor mrt4"
FT /id="PRO_0000154814"
SQ SEQUENCE 241 AA; 26664 MW; 5C6EADA96404DCA8 CRC64;
MPKSRRSKVL TLAQTEKKGH EGKAALFSGV QQSLDSFDYM WIFDVTNMRN TYLKRIRDDW
KGSRIFMGKT KVMAKALGHT PEEEHAENVS KLTKLLHGAV GLLFTNSKPD EVIGYFESFV
QNDFARAGAV APFTHVIPAG PVYSRAGQIP VEDDILLTHT LEPQVRQLGM PTVLKNGVVT
LLADFPLCTE GQQLDSRQTR LLKLFGITAA EFKVGLLGYY SKKGASVEFL QSAPGADEAM
E
