ID   MRTFB_XENLA             Reviewed;        1067 AA.
AC   Q8AYC1;
DT   27-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Myocardin-related transcription factor B;
DE            Short=MRTF-B;
DE            Short=xMRTF-B;
GN   Name=mrtfb;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12397177; DOI=10.1073/pnas.222561499;
RA   Wang D.-Z., Li S., Hockemeyer D., Sutherland L., Wang Z., Schratt G.,
RA   Richardson J.A., Nordheim A., Olson E.N.;
RT   "Potentiation of serum response factor activity by a family of myocardin-
RT   related transcription factors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14855-14860(2002).
CC   -!- FUNCTION: Poor transcriptional factor which uses the canonical single
CC       or multiple CArG boxes DNA sequence. Acts as a cofactor of serum
CC       response factor (SRF) with the potential to modulate SRF target genes
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SRF. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The N-terminal region is required for nuclear localization and
CC       the C-terminal region mediates transcriptional activity. {ECO:0000250}.
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DR   EMBL; AF532600; AAN33044.1; -; mRNA.
DR   RefSeq; NP_001079234.1; NM_001085765.1.
DR   AlphaFoldDB; Q8AYC1; -.
DR   SMR; Q8AYC1; -.
DR   PRIDE; Q8AYC1; -.
DR   GeneID; 378496; -.
DR   CTD; 378496; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR   Gene3D; 1.10.720.30; -; 1.
DR   InterPro; IPR043451; Myocardin-like.
DR   InterPro; IPR004018; RPEL_repeat.
DR   InterPro; IPR003034; SAP_dom.
DR   InterPro; IPR036361; SAP_dom_sf.
DR   PANTHER; PTHR22793; PTHR22793; 1.
DR   Pfam; PF02755; RPEL; 2.
DR   Pfam; PF02037; SAP; 1.
DR   SMART; SM00707; RPEL; 3.
DR   SMART; SM00513; SAP; 1.
DR   SUPFAM; SSF68906; SSF68906; 1.
DR   PROSITE; PS51073; RPEL; 3.
DR   PROSITE; PS50800; SAP; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1067
FT                   /note="Myocardin-related transcription factor B"
FT                   /id="PRO_0000126630"
FT   REPEAT          46..71
FT                   /note="RPEL 1"
FT   REPEAT          90..115
FT                   /note="RPEL 2"
FT   REPEAT          134..159
FT                   /note="RPEL 3"
FT   DOMAIN          390..424
FT                   /note="SAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00186"
FT   REGION          175..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          249..286
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          799..829
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          540..594
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1067 AA;  117093 MW;  08F37372C02C9EA1 CRC64;
     MIDSSKKQQQ QPPQHYSFAD ILSAGDLDPL KEKEWLDPGS QKSLKEVLQL RLQQRRTREQ
     LVDQGIMPPL KSPAAFHEQI KSLERARTEN FLKHKIRSRP NRSELVRMHI LEETLAEPSL
     QATQLKLKRA RLADDLNEKI AQRPGPLELV EKNILPVDLS VKEAITVSQT NLPENLDTLS
     FDEDSSDALS PEQPASQESQ GSAASPGEMK TSDSSSPVSN TTIQCQTVSS PLPDFFKPVP
     TADLTTRSPL SCIVSKPGPA LIKQTQPKHT EKPRSKKSKD PKPRVKKLKY HQYIPPDQKG
     EKIEEEMDSN YARLLQQQQL VLQLQILSQQ HSTLTTSRKS YPAPLKSQKK QNTINTTICN
     GNAGAPPAQC SVNRQNSVPC KKTGPLPSSL DDMKVAELKM ELKLRGLPVS GTKMDLIERL
     KPFQDFSSNG VSPSSANTVN ITNPACNTTD DATTAFSTSA LINSSSPTPS VSIGNNQTML
     DGINSPLPMS PTPSEQSNFS SEDTNITDTF AEILTMMSPS QFMNTSPLKV NEDSMGATPG
     NTPNVELDAV EKDRKLQEKE KQIEELKRKL EQEQKLVEVL KKQLELEKRG QQQQPCSNVL
     LKMEPKHFNL QIKEETEAPD CQNSKQPVGS GGQILGQATA ATISQNIIAN NAVVIKHEVP
     LAKPEHQNVI QQFYVTSQRP PQTAVVAQPQ ALLATQTAQL LLPLSIKAAN GVQLSMVQAQ
     PHTVNPAPAQ LSTAAATTTT LLSAPPKQSA PPTQDKFTPH LLNQNQQIRK LCPSATSGNV
     FSYPQNPVTA VPQSFSASIS TSAQPQRSTQ LTAVQNGPTS LHEKSSTPPQ LQQFIVQQHP
     LFSSPTTKSK DPPRYEEAIK QARNNPASQP EVSNAHSQQM DDLFDILIKS GEMSPLIKEP
     SPISKMRPVT ANVTTMPVNT VVSRPPPQIH MAPPLSLEST NSLSVSLESQ LEAFLDGTLP
     SGNNIPHLES NSDDRETFSL IDDLNNDLLQ NTAMLEHEST PMETTDTPFT ANSCLSLDLA
     DANLDNMEWL DLTMPNSSSS LTPLSSTLPS MFSTDFLDSN DLHLHWE