MRX10_YEAST
ID MRX10_YEAST Reviewed; 414 AA.
AC Q05648; D6VSR2;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=MIOREX complex component 10 {ECO:0000305|PubMed:25683707};
DE AltName: Full=Mitochondrial organization of gene expression protein 10 {ECO:0000303|PubMed:25683707};
DE Flags: Precursor;
GN Name=MRX10 {ECO:0000303|PubMed:25683707};
GN OrderedLocusNames=YDR282C {ECO:0000312|SGD:S000002690};
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP SUBCELLULAR LOCATION, AND TOPOLOGY.
RX PubMed=23022099; DOI=10.1016/j.ajhg.2012.08.019;
RA Garcia-Diaz B., Barros M.H., Sanna-Cherchi S., Emmanuele V., Akman H.O.,
RA Ferreiro-Barros C.C., Horvath R., Tadesse S., El Gharaby N., DiMauro S.,
RA De Vivo D.C., Shokr A., Hirano M., Quinzii C.M.;
RT "Infantile encephaloneuromyopathy and defective mitochondrial translation
RT are due to a homozygous RMND1 mutation.";
RL Am. J. Hum. Genet. 91:729-736(2012).
RN [4]
RP FUNCTION, AND SUBUNIT.
RX PubMed=25683707; DOI=10.1016/j.celrep.2015.01.012;
RA Kehrein K., Schilling R., Moller-Hergt B.V., Wurm C.A., Jakobs S.,
RA Lamkemeyer T., Langer T., Ott M.;
RT "Organization of mitochondrial gene expression in two distinct ribosome-
RT containing assemblies.";
RL Cell Rep. 10:843-853(2015).
CC -!- FUNCTION: Component of MIOREX complexes, large expressome-like
CC assemblies of ribosomes with factors involved in all the steps of post-
CC transcriptional gene expression. {ECO:0000269|PubMed:25683707}.
CC -!- SUBUNIT: Associates with the mitochondrial ribosome.
CC {ECO:0000269|PubMed:25683707}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:23022099}; Single-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the RMD1/sif2 family. {ECO:0000305}.
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DR EMBL; U51030; AAB64460.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA12122.1; -; Genomic_DNA.
DR PIR; S70138; S70138.
DR RefSeq; NP_010568.3; NM_001180590.3.
DR AlphaFoldDB; Q05648; -.
DR BioGRID; 32335; 53.
DR STRING; 4932.YDR282C; -.
DR MaxQB; Q05648; -.
DR PaxDb; Q05648; -.
DR PRIDE; Q05648; -.
DR EnsemblFungi; YDR282C_mRNA; YDR282C; YDR282C.
DR GeneID; 851876; -.
DR KEGG; sce:YDR282C; -.
DR SGD; S000002690; MRX10.
DR VEuPathDB; FungiDB:YDR282C; -.
DR eggNOG; KOG2861; Eukaryota.
DR GeneTree; ENSGT00390000013337; -.
DR HOGENOM; CLU_011220_0_0_1; -.
DR InParanoid; Q05648; -.
DR OMA; QVIHVQT; -.
DR BioCyc; YEAST:G3O-29847-MON; -.
DR PRO; PR:Q05648; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; Q05648; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:SGD.
DR GO; GO:0070131; P:positive regulation of mitochondrial translation; IBA:GO_Central.
DR InterPro; IPR003734; DUF155.
DR Pfam; PF02582; DUF155; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..29
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 30..414
FT /note="MIOREX complex component 10"
FT /id="PRO_0000229731"
FT TOPO_DOM 30..373
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000305|PubMed:23022099"
FT TRANSMEM 374..394
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 395..414
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000269|PubMed:23022099"
SQ SEQUENCE 414 AA; 47173 MW; D36CA1602BE840D9 CRC64;
MLSFRSLTST FGFVSRFQIR RLGTSLSIQN LEVQDGRWKG KLATEKKTNR EHKSVDTNIK
TMKMLKNPKN STRYLRRSFV PNHRKQENGR DILEDSLSKD HLKVKSCITI TTGEGYDLKR
CMKLLTMQGL QPTNLIPDEI VSFSYQDNGN KGDVMILGQN GSIVSWGFSE SSVRNCIVPI
VKAASLNPLN GEDFETEDMD YVEIEGEQDF DKLSSLDNKV TPRIACESFL SGDLIIINSL
DSDQGMLDKA AFSSGLSRST NLAVLEEAME KHISKTRTIT ENISKGTKLN LRSSDALKSI
GRLFLIRGKL NLYSELIETP DLYWSEPQLE EIFKNVSRYL DIGPRINILN SKLDYSTDEC
RALISLLNER NSTFLEWIII YLIAFELCFE IYHFYQKYSS YCSEPTNDDL DATK
